(2R,6R)-hydroxynorketamine acts through GluA1-induced synaptic plasticity to alleviate PTSD-like effects in rat models

Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD

(2022) Juan Wang et al.   PHARMACOLOGICAL RESEARCH

Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice

(2022) Akiko Oota-Ishigaki et al.   NEUROPSYCHOPHARMACOLOGY

Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

(2021) Leonardo Santana Novaes et al.   Translational Psychiatry

BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model

(2021) Shao-Han Chang et al.   BEHAVIOURAL NEUROLOGY

Prefrontal cortex, amygdala, and threat processing: implications for PTSD

(2021) M. Alexandra Kredlow et al.   NEUROPSYCHOPHARMACOLOGY

A unifying translational framework to advance treatment research for comorbid PTSD and substance use disorders

(2021) Denise A. Hien et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

(2021) J. Blaze et al.   Nature Communications

GluA1-homomeric AMPA receptor in synaptic plasticity and neurological diseases

(2021) Yuan Ge et al.   NEUROPHARMACOLOGY

Translational relevance of behavioral, neural, and electroencephalographic profiles in a mouse model of post-traumatic stress disorder

(2021) Kaiwen Xi et al.   Neurobiology of Stress

Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine

(2020) Briana K. Chen et al.   NEUROPSYCHOPHARMACOLOGY

The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD

(2020) Lianghui Ni et al.   Translational Psychiatry

Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions

(2020) Dylan Chou   NEUROPHARMACOLOGY

Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain

(2019) Jeffrey S Kroin et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

(2R,6R)-hydroxynorketamine exerts mGlu2receptor-dependent antidepressant actions

(2019) Panos Zanos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

(2019) Eric W. Lumsden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Okadaic acid attenuates short-term and long-term synaptic plasticity of hippocampal dentate gyrus neurons in rats

(2019) Nasrin Hamidi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials

(2019) Michael C. Mithoefer et al.   PSYCHOPHARMACOLOGY

Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD)

(2019) Yasushi Yabuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors

(2019) Dong Xiao et al.   NEUROCHEMICAL RESEARCH

Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine

(2019) Christopher L. Shaffer et al.   NEUROPHARMACOLOGY

(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism

(2019) Lace M. Riggs et al.   NEUROPSYCHOPHARMACOLOGY

Post‐traumatic stress disorder: a state‐of‐the‐art review of evidence and challenges

(2019) Richard A. Bryant   World Psychiatry

Ketamine metabolite (2R,6R)-hydroxynorketamine enhances aggression via periaqueductal gray glutamatergic transmission

(2019) Lichao Ye et al.   NEUROPHARMACOLOGY

Dynamic monitoring of depressive behavior induced by nonylphenol and its effect on synaptic plasticity in rats

(2019) Jie Yu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Pathophysiological Bases of Comorbidity: Traumatic Brain Injury and Post-Traumatic Stress Disorder

(2018) Gary B. Kaplan et al.   JOURNAL OF NEUROTRAUMA

Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety

(2018) Rodrigo Bainy Leal et al.   MOLECULAR PSYCHIATRY

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice

(2018) Hanjie Yu et al.   NEUROPHARMACOLOGY

(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray

(2018) Dylan Chou et al.   NEUROPHARMACOLOGY

Quantitative Proteomic Analysis Reveals Synaptic Dysfunction in the Amygdala of Rats Susceptible to Chronic Mild Stress

(2018) Mi Zhou et al.   NEUROSCIENCE

Applying ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF

(2018) Lanwei Hou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine

(2018) Jaclyn N Highland et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Modelling posttraumatic stress disorders in animals

(2018) Bibiana Török et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1

(2017) Jorge A. Avila et al.   HIPPOCAMPUS

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit

(2017) N Yao et al.   MOLECULAR PSYCHIATRY

Effects of a ketamine metabolite on synaptic NMDAR function

(2017) Kanzo Suzuki et al.   NATURE

Pharmacodynamic and pharmacokinetic interactions between simvastatin and diazepam in rats

(2017) Wojciech Słupski et al.   Pharmacological Reports

Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress

(2017) Congli Hu et al.   PLoS One

Emotion and the prefrontal cortex: An integrative review.

(2017) Matthew L. Dixon et al.   PSYCHOLOGICAL BULLETIN

Glutamate Deregulation in Ketamine-Induced Psychosis—A Potential Role of PSD95, NMDA Receptor and PMCA Interaction

(2017) Malwina Lisek et al.   Frontiers in Cellular Neuroscience

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic

(2017) John H. Krystal et al.   Current Psychiatry Reports

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Down-regulation of Stargazin Inhibits the Enhanced Surface Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor GluR1 Subunit in Rat Dorsal Horn and Ameliorates Postoperative Pain

(2014) Ruijuan Guo et al.   ANESTHESIOLOGY

Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test

(2014) Arya Haj-Mirzaian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder

(2014) Adriana Feder et al.   JAMA Psychiatry

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

Form follows function: BDNF and its involvement in sculpting the function and structure of synapses

(2013) Marta Zagrebelsky et al.   NEUROPHARMACOLOGY

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Fear extinction and BDNF: translating animal models of PTSD to the clinic

(2012) R. Andero et al.   GENES BRAIN AND BEHAVIOR

Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar–Kyoto rats

(2012) Y. Tizabi et al.   NEUROSCIENCE

Impact of Pharmacological Treatments on Cognitive and Behavioral Outcome in the Postacute Stages of Adult Traumatic Brain Injury

(2011) Patricia Wheaton et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Insulin receptor substrate 2 is a negative regulator of memory formation

(2011) E. E. Irvine et al.   LEARNING & MEMORY

Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex

(2011) F. Wang et al.   SCIENCE

Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn

(2010) Ji-Tain Xu et al.   BRAIN RESEARCH

Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats

(2009) Hua-Ning Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder

(2009) Liliana Dell'Osso et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A modified single-prolonged stress model for post-traumatic stress disorder

(2008) Wen Wang et al.   NEUROSCIENCE LETTERS