Synthesis and Anticancer Evaluation of Novel Indole Based Arylsulfonylhydrazides against Human Breast Cancer Cells

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

(2022) Mohammed S. Taghour et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Indole: A Privileged Heterocyclic Moiety in the Management of Cancer

(2021) Reyaz Hassan Mir et al.   CURRENT ORGANIC CHEMISTRY

Design, synthesis and broad spectrum antibreast cancer activity of diarylindoles via induction of apoptosis in aggressive breast cancer cells

(2021) Yashveer Gautam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

(2021) Mudasir Nabi Peerzada et al.   PHARMACOLOGY & THERAPEUTICS

Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

(2021) Yichao Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin-derived hybrids and their anticancer activity

(2020) Feng Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitrogen Containing Heterocycles as Anticancer Agents: An Overview

(2020) Damanpreet K. Lang et al.   Anti-Cancer Agents in Medicinal Chemistry

Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors

(2020) Shubham Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Revealing quinquennial anticancer journey of morpholine: A SAR based review

(2019) Fatima Arshad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules

(2019) Angeliki P. Kourounakis et al.   MEDICINAL RESEARCH REVIEWS

Synthesis and cytotoxicity evaluation of glycosidic derivatives of lawsone against breast cancer cell lines

(2019) Flaviano M. Ottoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An insight into the medicinal perspective of synthetic analogs of indole: A review

(2019) Punniyakoti Veeraveedu Thanikachalam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole: A privileged scaffold for the design of anti-cancer agents

(2019) Yichao Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms

(2018) Sakineh Dadashpour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Facile synthesis of simple 2-oxindole-based compounds with promising antiproliferative activity

(2018) Riham F George   Future Medicinal Chemistry

Selective Construction of 2-Substituted Benzothiazoles from o-Iodoaniline Derivatives S8 and N-Tosylhydrazones

(2018) Yubing Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Derivatives of 4,5-dihydro (1H) pyrazoles as possible MAO-A inhibitors in depression and anxiety disorders: synthesis, biological evaluation and molecular modeling studies

(2018) Avinash C. Tripathi et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, Structure, Chemical Stability, and In Vitro Cytotoxic Properties of Novel Quinoline-3-Carbaldehyde Hydrazones Bearing a 1,2,4-Triazole or Benzotriazole Moiety

(2018) Martyna Korcz et al.   MOLECULES

Anti-cancer Nitrogen-Containing Heterocyclic Compounds

(2018) Zahra Hosseinzadeh et al.   CURRENT ORGANIC CHEMISTRY

Research advances on anticancer activities of matrine and its derivatives: An updated overview

(2018) Haroon ur Rashid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiproliferative activity of morpholine-based compounds on MCF-7 breast cancer, colon carcinoma C26, and normal fibroblast NIH-3T3 cell lines and study of their binding affinity to calf thymus-DNA and bovine serum albumin

(2018) Mahboubeh Hosseini-Kharat et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties

(2017) Peng-Cheng Diao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, molecular modeling, and ADMET studies of some pyrazoline derivatives as shikimate kinase inhibitors

(2017) Jainey P. James et al.   MEDICINAL CHEMISTRY RESEARCH

Kinase Inhibitor Indole Derivatives as Anticancer Agents: A Patent Review

(2017) Anuj K. Rathi et al.   Recent Patents on Anti-Cancer Drug Discovery

Design, synthesis and DNA-binding study of some novel morpholine linked thiazolidinone derivatives

(2017) Javeed Ahmad War et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis and biological screening for cytotoxic activity of N-substituted indolines and morpholines

(2016) Phuong Doan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies

(2016) Belgin Sever et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole Derivatives as Anticancer Agents for Breast Cancer Therapy: A Review

(2015) Jagpreet Singh Sidhu et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis of heterocycle-attached methylidenebenzenesulfonohydrazones as antifungal agents

(2015) Zhinan Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and Optimization of a Series of 1-Sulfonylpyrazolo[4,3-b]pyridines as Selective c-Met Inhibitors

(2015) Yuchi Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

(2015) Pedro Martins et al.   MOLECULES

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

(2014) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, characterization, electrochemical behavior, and antimicrobial activities of aromatic/heteroaromatic sulfonylhydrazone derivatives

(2014) Ayla Balaban Gündüzalp et al.   MEDICINAL CHEMISTRY RESEARCH

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors

(2013) Xiaoke Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization, and Crystal Structure in Complex with the Target

(2013) Roberta Costi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

(2013) Kevin M. Foote et al.   JOURNAL OF MEDICINAL CHEMISTRY