Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Review
Endocrinology & Metabolism
Milan Obradovic, Emina Sudar-Milovanovic, Sanja Soskic, Magbubah Essack, Swati Arya, Alan J. Stewart, Takashi Gojobori, Esma R. Isenovic
Summary: Leptin, a peptide hormone, regulates food intake, body mass, and reproductive function, playing a crucial role in fetal growth, immune responses, angiogenesis, and lipolysis. Leptin resistance can lead to reduced satiety, overconsumption of nutrients, and increased body mass, potentially causing obesity. Combining leptin therapies with sensitizers may help overcome resistance and treat obesity effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Nikolai P. Jaschke, Sophie Paehlig, Tilman D. Rachner
Summary: Soluble mediators secreted by skeletal muscles, known as myokines, signal to distant organs and play a role in protecting the central nervous system against pathological protein accumulation in response to stress. Rai et al. have uncovered a muscle-to-central nervous system signaling axis that is engaged during proteostatic stress.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Stephanie Brandt, Julia von Schnurbein, Christian Denzer, Wolfgang Kratzer, Martin Wabitsch
Summary: Circulating leptin levels in pre-pubertal children with obesity are negatively associated with steatosis hepatis, and children with low leptin levels have higher triglyceride, fasting insulin, and c-peptide levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Xin Su, Ye Cheng, Dong Chang
Summary: Obesity is associated with dysfunctional adipocytes that produce excessive pro-inflammatory adipokines, while leptin plays a vital role in regulating angiogenesis, lipid metabolism, and cytokine production. Increased leptin levels and impaired signaling pathway can impact various skin diseases, highlighting the complex relationship between leptin and dermatological disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Youchao Xiao, Wentao Wu, Kefan Cai, Lu Jin, Yanfei Jia, Ning Qiao, Fangzheng Liu, Siming Ru, Lei Cao, Songbai Gui
Summary: Craniopharyngioma (CP) is a benign tumor associated with obesity and recurrence. The role of leptin/leptin receptors axis in CP and its association with weight-related outcomes and prognosis were studied. High plasma leptin level and leptin receptor overexpression were found in CP patients, which were independent risk factors for weight gain and poor progression-free survival (PFS). Leptin/leptin receptors axis may be a potential therapeutic target for obesity in CP patients.
Article
Endocrinology & Metabolism
Christine Sommer, Kjersti G. Vangberg, Gunn-Helen Moen, David M. Evans, Sindre Lee-Odegard, Ingvild K. Blom-Hogestol, Line Sletner, Anne K. Jenum, Christian A. Drevon, Hanne L. Gulseth, Kare Birkeland
Summary: This study investigates the influence of glucose, insulin, body fat, BMI, food intake, and physical activity on serum sOb-R levels. The researchers found that BMI and insulin were causally linked to decreased sOb-R levels, while intensive exercise and food intake acutely increased sOb-R levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Mahmoud A. Alfaqih, Lina Elsalem, Mohamad Nusier, Khawla Mhedat, Yousef Khader, Ebaa Ababneh
Summary: This study found a correlation between obesity and increased risk of bladder cancer. The levels of leptin and its receptor are often deregulated in obese individuals and these changes are associated with the development of bladder cancer. Additionally, certain genetic variants are also associated with bladder cancer.
Review
Endocrinology & Metabolism
Kenny Mendoza-Herrera, Andrea A. Florio, Maggie Moore, Abrania Marrero, Martha Tamez, Shilpa N. Bhupathiraju, Josiemer Mattei
Summary: This review focuses on the relationship between diet and leptin, suggesting that addressing leptin resistance through dietary interventions can counteract obesity. High-fat, high-carbohydrate, fructose, and sucrose diets, low in protein, contribute to leptin resistance, while energy-restricted diets can reduce leptin levels and potentially reverse resistance. Further research on reliable methods to measure resistance and alternative approaches like leptin sensitizers and genetically individualized diets is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karolina Wolodko, Juan Castillo-Fernandez, Gavin Kelsey, Antonio Galvao
Summary: Maternal obesity can lead to impaired leptin signaling, resulting in high levels of estrogen and leptin in the bloodstream, which adversely affects ovarian function. This review highlights the potential impact of impaired leptin signaling on folliculogenesis and oocyte developmental competence in both mice and women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sergio Montserrat-de la Paz, Antonio Perez-Perez, Teresa Vilarino-Garcia, Carlos Jimenez-Cortegana, Francisco Javier G. Muriana, Maria C. Millan-Linares, Victor Sanchez-Margalet
Summary: Obesity is characterized by the accumulation and dysregulation of adipose tissue, often accompanied by resistance to leptin and elevated leptin levels. Leptin, a hormone produced by adipose tissue, plays a crucial role in energy homeostasis. Dietary components can modulate leptin metabolism, with some reducing inflammation and enhancing leptin sensitivity, while others may exacerbate chronic inflammation and increase the risk of complications. Research into nutritional mechanisms to restore leptin metabolism could lead to new treatment options for obesity-related disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Juan Antonio Flores-Cordero, Antonio Perez-Perez, Carlos Jimenez-Cortegana, Gonzalo Alba, Alfonso Flores-Barragan, Victor Sanchez-Margalet
Summary: Obesity is a global health problem and leptin resistance, a mechanism of obesity, is associated with the development of Alzheimer's Disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yang Wang, Chengping Hu
Summary: Leptin, as an adipokine, plays a role in the proinflammatory obese-associated phenotype and is implicated in the pathology of asthma. Studies have shown that leptin affects adipogenesis, chronic inflammation, immune cell pathways, and has both positive and negative effects on asthma development. However, the conclusive effects of leptin on asthma are not well elucidated and require further research.
Review
Endocrinology & Metabolism
Jose L. Santos, Victor A. Cortes
Summary: Most known types of nonsyndromic monogenic obesity are caused by rare mutations in genes of the leptin-melanocortin pathway controlling appetite and adiposity, while congenital generalized lipodystrophy is the most extreme form of leanness in humans caused by recessive mutations in four genes. Both conditions result in altered eating behavior and metabolic abnormalities, but exogenous leptin or drug treatments can have beneficial effects.
