Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

The spectrum of noncoeliac gluten sensitivity

(2015) Imran Aziz et al.   Nature Reviews Gastroenterology & Hepatology

Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo

(2014) Mi Liu et al.   Nature Communications

The influence of PAMAM dendrimers surface groups on their interaction with porcine pepsin

(2013) Michal Ciolkowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Charge affects the oral toxicity of poly(amidoamine) dendrimers

(2013) Giridhar Thiagarajan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates

(2013) Gregor Fuhrmann et al.   Nature Chemistry

Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives

(2013) Gregor Fuhrmann et al.   PHARMACEUTICAL RESEARCH

Molecular Sieving on the Surface of a Protein Provides Protection Without Loss of Activity

(2012) Mi Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Transepithelial transport and toxicity of PAMAM dendrimers: Implications for oral drug delivery

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How PEGylation Enhances the Stability and Potency of Insulin: A Molecular Dynamics Simulation

(2011) Cheng Yang et al.   BIOCHEMISTRY

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract

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Effects of Polymer Molecular Weight on the Size, Activity, and Stability of PEG-Functionalized Trypsin

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Polymer–protein conjugates: an enzymatic activity perspective

(2010) Marc A. Gauthier et al.   Polymer Chemistry

Precision Polymers: Monodisperse, Monomer-Sequence-Defined Segments to Target Future Demands of Polymers in Medicine

(2009) L. Hartmann et al.   ADVANCED MATERIALS

Protein therapeutics: a summary and pharmacological classification

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