Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives

Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: A candidate for enzyme replacement therapy

(2013) H. Wang et al.   BIOPHYSICAL CHEMISTRY

Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates

(2013) Gregor Fuhrmann et al.   Nature Chemistry

Molecular Sieving on the Surface of a Protein Provides Protection Without Loss of Activity

(2012) Mi Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Review article: coeliac disease, new approaches to therapy

(2012) S. Rashtak et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Celiac Disease: Advances in Treatment via Gluten Modification

(2012) Samantha Stoven et al.   Clinical Gastroenterology and Hepatology

Microencapsulation of probiotics for gastrointestinal delivery

(2012) Michael T. Cook et al.   JOURNAL OF CONTROLLED RELEASE

Computational Design of an α-Gliadin Peptidase

(2012) Sydney R. Gordon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chronic Pancreatitis and Persistent Steatorrhea: What Is the Correct Dose of Enzymes?

(2011) J. Enrique Domínguez–Muñoz   Clinical Gastroenterology and Hepatology

Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials

(2011) Matthew Siegel et al.   DIGESTIVE DISEASES AND SCIENCES

The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues

(2011) Maud Pinier et al.   GASTROENTEROLOGY

Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria

(2011) Christineh N. Sarkissian et al.   MOLECULAR GENETICS AND METABOLISM

Up to date knowledge on different treatment strategies for phenylketonuria

(2011) Amaya Bélanger-Quintana et al.   MOLECULAR GENETICS AND METABOLISM

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

(2011) Rinkoo D Gupta et al.   Nature Chemical Biology

The role of fecal elastase-1 in detecting exocrine pancreatic disease

(2011) John S. Leeds et al.   Nature Reviews Gastroenterology & Hepatology

In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract

(2011) G. Fuhrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review article: enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer

(2010) C. W. Imrie et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Prevention Measures and Exploratory Pharmacological Treatments of Celiac Disease

(2010) Maud Pinier et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Stabilization of a supplemental digestive enzyme by post-translational engineering using chemically-activated polyethylene glycol

(2010) Kevin M. Turner et al.   BIOTECHNOLOGY LETTERS

Pancreatic Insufficiency in Adult Celiac Disease: Do Patients Require Long-Term Enzyme Supplementation?

(2010) Kate E. Evans et al.   DIGESTIVE DISEASES AND SCIENCES

Pegloticase

(2010) Naomi Schlesinger et al.   NATURE REVIEWS DRUG DISCOVERY

The spectrum of celiac disease: epidemiology, clinical aspects and treatment

(2010) Greetje J. Tack et al.   Nature Reviews Gastroenterology & Hepatology

Mortality in celiac disease

(2010) Federico Biagi et al.   Nature Reviews Gastroenterology & Hepatology

A novel acid-stable, acid-active β-galactosidase potentially suited to the alleviation of lactose intolerance

(2009) Shane O’Connell et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo

(2009) Jason A. Tye-Din et al.   CLINICAL IMMUNOLOGY

Molecular characterization, physicochemical properties, known and potential applications of phytases: An overview

(2009) D.E.C.S. Rao et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

An Acidophilic β-Galactosidase fromBisporasp. MEY-1 with High Lactose Hydrolytic Activity under Simulated Gastric Conditions

(2009) Hui Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polymer Masked−Unmasked Protein Therapy. 1. Bioresponsive Dextrin−Trypsin and −Melanocyte Stimulating Hormone Conjugates Designed for α-Amylase Activation

(2008) Ruth Duncan et al.   BIOMACROMOLECULES

Celiac disease

(2008) Carlo Catassi et al.   CURRENT OPINION IN GASTROENTEROLOGY

Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria

(2008) C. N. Sarkissian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein engineering of improved prolyl endopeptidases for celiac sprue therapy

(2008) Jennifer Ehren et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Specificity of immobilized porcine pepsin in H/D exchange compatible conditions

(2008) Yoshitomo Hamuro et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY