IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Development of a force field for the simulation of single-chain proteins and protein-protein complexes

(2020) Stefano Piana et al.   Journal of Chemical Theory and Computation

CD29 identifies IFN-γ–producing human CD8+T cells with an increased cytotoxic potential

(2020) Benoît P. Nicolet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

(2020) Hao Wu et al.   Nature Communications

Fine-Tuning Cytokine Signals

(2019) Jian-Xin Lin et al.   Annual Review of Immunology

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies

(2018) Suman Mitra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

DIALS: implementation and evaluation of a new integration package

(2018) Graeme Winter et al.   Acta Crystallographica Section D-Structural Biology

Mapping Determinants of Cytokine Signaling via Protein Engineering

(2018) Claire Gorby et al.   Frontiers in Immunology

Lactic Acid Accumulation in the Tumor Microenvironment Suppresses 18F-FDG Uptake

(2018) Silvan Türkcan et al.   CANCER RESEARCH

CD8 + T Cells Orchestrate pDC-XCR1 + Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

(2017) Anna Brewitz et al.   IMMUNITY

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

(2015) Robert T. McGibbon et al.   BIOPHYSICAL JOURNAL

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

Water Dispersion Interactions Strongly Influence Simulated Structural Properties of Disordered Protein States

(2015) Stefano Piana et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

Adoptive Cell Therapy—Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors

(2015) Steven A. Feldman et al.   SEMINARS IN ONCOLOGY

Dynamic Submicroscopic Signaling Zones Revealed by Pair Correlation Tracking and Localization Microscopy

(2014) Changjiang You et al.   ANALYTICAL CHEMISTRY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

Mechanisms of Jak/STAT Signaling in Immunity and Disease

(2014) Alejandro V. Villarino et al.   JOURNAL OF IMMUNOLOGY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+ T Cells Produce the Chemokine CXCL10 in Response to CD27/CD70 Costimulation To Promote Generation of the CD8+ Effector T Cell Pool

(2013) V. Peperzak et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Development and validation of a multiplex quantitative polymerase chain reaction assay for the detection of Mollicutes impurities in human cells, cultured under good manufacturing practice conditions, and following European Pharmacopoeia requirements and the International Conference on Harmonization guidelines

(2012) Irene Vanni et al.   CYTOTHERAPY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Cytokines and the inception of CD8 T cell responses

(2011) Maureen A. Cox et al.   TRENDS IN IMMUNOLOGY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

(2010) C. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes

(2008) Jan Vogelsang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology