Identification of MKNK1 and TOP3A as ovarian endometriosis risk-associated genes using integrative genomic analyses and functional experiments

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19

(2022) Yunlong Ma et al.   Genome Medicine

Transcription factor HOXB2 upregulates NUSAP1 to promote the proliferation, invasion and migration of nephroblastoma cells via the PI3K/Akt signaling pathway

(2022) Bo Luo et al.   Molecular Medicine Reports

Integration of genome-wide association study and expression quantitative trait locus mapping for identification of endometriosis-associated genes

(2021) Ya-Ching Chou et al.   Scientific Reports

Integrative Genomics Analysis Reveals a 21q22.11 Locus Contributing Risk to COVID-19

(2021) Yunlong Ma et al.   HUMAN MOLECULAR GENETICS

Estrogen suppresses HOXB2 expression via ERα in breast cancer cells

(2021) Ajay Kumar et al.   GENE

Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing

(2021) Imane Lalami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Update on the Development of MNK Inhibitors as Therapeutic Agents

(2021) Weijun Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single cell sequencing analysis identifies genetics-modulated ORMDL3+ cholangiocytes having higher metabolic effects on primary biliary cholangitis

(2021) Bingyu Xiang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma

(2020) Fengkai Xu et al.   Cell Communication and Signaling

MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression

(2020) William Yang et al.   ONCOGENE

Endometriosis

(2020) Krina T. Zondervan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma

(2020) Xiuqing Ma et al.   BMC Medical Genomics

Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets

(2020) Zhouzhou Dong et al.   BMC Pulmonary Medicine

MNK1/NODAL signaling promotes invasive progression of breast ductal carcinoma in situ

(2019) Qianyu Guo et al.   CANCER RESEARCH

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

(2019) Jingmei Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Discovery of non-invasive biomarkers for the diagnosis of endometriosis

(2019) Stella Irungu et al.   Clinical Proteomics

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

HOXB2 is a Putative Tumour Promotor in Human Bladder Cancer

(2019) JIA LIU et al.   ANTICANCER RESEARCH

Immunohistochemical Features of O6-Methylguanine-DNA Methyltransferase Expression during Ovarian Endometriosis

(2018) A. I. Shchegolev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

(2018) Thomas J. Nicholls et al.   MOLECULAR CELL

Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

(2018) Cui-Ping Yang et al.   Nature Communications

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

(2017) Yao Zhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I DNA Topoisomerases

(2017) Giovanni Capranico et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

(2017) Yadav Sapkota et al.   Nature Communications

Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis

(2017) Yunlong Ma et al.   Scientific Reports

Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

(2017) Gina M. Calabrese et al.   Cell Systems

Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma

(2016) Hong Zhan et al.   HUMAN REPRODUCTION

Endometrial vezatin and its association with endometriosis risk

(2016) Sarah J. Holdsworth-Carson et al.   HUMAN REPRODUCTION

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

(2016) Jennifer M. Whitehead Pavlides et al.   Genome Medicine

Heritability of endometriosis

(2015) Rama Saha et al.   FERTILITY AND STERILITY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

(2014) N Robichaud et al.   ONCOGENE

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

(2013) Xin He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Expression quantitative trait loci: present and future

(2013) A. C. Nica et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genome-wide association meta-analysis identifies new endometriosis risk loci

(2012) Dale R Nyholt et al.   NATURE GENETICS

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1

(2010) Jay Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional expression of type-I interferon response genes and stability of housekeeping genes in the human endometrium and endometriosis

(2010) Anna L. Vestergaard et al.   MOLECULAR HUMAN REPRODUCTION

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis

(2010) Jodie N Painter et al.   NATURE GENETICS

A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese

(2010) Satoko Uno et al.   NATURE GENETICS

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

(2009) Maria Teresa Landi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Enhanced expressions of matrix metalloproteinase (MMP)-2 and –9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding

(2009) Xinmei Zhang et al.   FERTILITY AND STERILITY