Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro

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302 A phase 1 study of EPZ-6438 (E7438), an Enhancer of Zeste-Homolog 2 (EZH2) inhibitor: Preliminary activity in INI1-negative tumors

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EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

(2015) John E. Campbell et al.   ACS Medicinal Chemistry Letters

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy

(2015) Torsten O. Nielsen et al.   Cancer Discovery

The Expanding Family of SMARCB1(INI1)-deficient Neoplasia

(2014) Abbas Agaimy   ADVANCES IN ANATOMIC PATHOLOGY

Metastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features

(2014) Joanna Przybyl et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A comprehensive transcriptional portrait of human cancer cell lines

(2014) Christiaan Klijn et al.   NATURE BIOTECHNOLOGY

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Molecular Pathways: Protein Methyltransferases in Cancer

(2013) R. A. Copeland   CLINICAL CANCER RESEARCH

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

(2013) Emily E. Carmody Soni et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas

(2013) Pauline Lagarde et al.   JOURNAL OF CLINICAL ONCOLOGY

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers

(2013) A. Hunter Shain et al.   PLoS One

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics

(2012) Le Su et al.   CANCER CELL

Combinatorial complexity in chromatin structure and function: revisiting the histone code

(2012) Oliver J Rando   CURRENT OPINION IN GENETICS & DEVELOPMENT

A unique pattern of INI1 immunohistochemistry distinguishes synovial sarcoma from its histologic mimics

(2012) Michael A. Arnold et al.   HUMAN PATHOLOGY

SS18 Together with Animal-Specific Factors Defines Human BAF-Type SWI/SNF Complexes

(2012) Evelien Middeljans et al.   PLoS One

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

Reduced expression of SMARCB1/INI1 protein in synovial sarcoma

(2010) Kenichi Kohashi et al.   MODERN PATHOLOGY

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitors Reverse SS18-SSX-Mediated Polycomb Silencing of the Tumor Suppressor Early Growth Response 1 in Synovial Sarcoma

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