Immunopathophysiology of human sepsis

Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures

(2022) Arjun Baghela et al.   EBioMedicine

Redefining critical illness

(2022) David M. Maslove et al.   NATURE MEDICINE

Sepsis Subclasses

(2021) Kimberley M. DeMerle et al.   CRITICAL CARE MEDICINE

Integrative Transkingdom Analysis of the Gut Microbiome in Antibiotic Perturbation and Critical Illness

(2021) Bastiaan W. Haak et al.   mSystems

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

(2021) Miguel Reyes et al.   Science Translational Medicine

Sepsis-Induced Immunosuppression

(2021) Lisa K. Torres et al.   Annual Review of Physiology

The immunology of sepsis

(2021) Tom van der Poll et al.   IMMUNITY

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

(2021) Laura Evans et al.   INTENSIVE CARE MEDICINE

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

(2020) Chao Ren et al.   Journal of Neuroinflammation

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

An immune-cell signature of bacterial sepsis

(2020) Miguel Reyes et al.   NATURE MEDICINE

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity

(2020) Sangman M. Kim et al.   Nature Communications

Mucosal or systemic microbiota exposures shape the B cell repertoire

(2020) Hai Li et al.   NATURE

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Disease Tolerance as an Inherent Component of Immunity

(2019) Rui Martins et al.   Annual Review of Immunology

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

(2019) Congqing Wu et al.   IMMUNITY

Viruses in Vietnamese patients presenting with community acquired sepsis of unknown cause

(2019) Anh To Nguyen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Prognostic and predictive enrichment in sepsis

(2019) Natalja L. Stanski et al.   Nature Reviews Nephrology

DAMPs and NETs in Sepsis

(2019) Naomi-Liza Denning et al.   Frontiers in Immunology

Check Point Inhibitors and Their Role in Immunosuppression in Sepsis

(2019) Michelle E. Wakeley et al.   CRITICAL CARE CLINICS

Current gaps in sepsis immunology: new opportunities for translational research

(2019) Ignacio Rubio et al.   LANCET INFECTIOUS DISEASES

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis

(2018) Joel R. Wilmore et al.   Cell Host & Microbe

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters

(2018) Timothy E. Sweeney et al.   CRITICAL CARE MEDICINE

Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients

(2018) Claude-Alexandre Gustave et al.   JOURNAL OF IMMUNOLOGY

Epidemiology and Immune Pathogenesis of Viral Sepsis

(2018) Gu-Lung Lin et al.   Frontiers in Immunology

Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis

(2018) Bastiaan W. Haak et al.   Frontiers in Immunology

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

(2018) David B Antcliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Kinase activity is impaired in neutrophils of sepsis patients

(2018) Arie J. Hoogendijk et al.   HAEMATOLOGICA

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

(2017) Sangeeta S. Chavan et al.   IMMUNITY

The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

(2017) Sohn Kim et al.   IMMUNOLOGICAL REVIEWS

Coagulation and sepsis

(2017) Marcel Levi et al.   THROMBOSIS RESEARCH

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

Protease-activated receptors in hemostasis

(2016) M. T. Nieman   BLOOD

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study

(2016) Jacqueline M. Lankelma et al.   INTENSIVE CARE MEDICINE

New Definitions for Sepsis and Septic Shock

(2016) Edward Abraham   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis

(2016) Lonneke A. van Vught et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

(2016) Andriani C. Patera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Myeloid-Derived Suppressor Cells in Bacterial Infections

(2016) Michael Ost et al.   Frontiers in Cellular and Infection Microbiology

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Extreme Dysbiosis of the Microbiome in Critical Illness

(2016) Daniel McDonald et al.   mSphere

Hospitalization Type and Subsequent Severe Sepsis

(2015) Hallie C. Prescott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

(2013) Jean-Marc Tadie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Host innate immune responses to sepsis

(2013) Willem Joost Wiersinga et al.   Virulence

Recognition of bacterial infection by innate immune sensors

(2012) Sushil Kumar et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Programmed Death 1 Expression as a Marker for Immune and Physiological Dysfunction in the Critically Ill Surgical Patient

(2012) Sean F. Monaghan et al.   SHOCK

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

(2010) R. Silasi-Mansat et al.   BLOOD

The complement system

(2010) J. Vidya Sarma et al.   CELL AND TISSUE RESEARCH

Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting

(2010) Alexander Lepak et al.   CRITICAL CARE CLINICS

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Priming of Alveolar Macrophages upon Instillation of Lipopolysaccharide in the Human Lung

(2009) Jacobien J. Hoogerwerf et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA