Cdk12 is essential for embryonic development and the maintenance of genomic stability

Maternal BCAS2 protects genomic integrity in mouse early embryonic development

(2015) Qianhua Xu et al.   DEVELOPMENT

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

(2015) Kingsley M. Ekumi et al.   NUCLEIC ACIDS RESEARCH

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression

(2014) Hong-Ru Chen et al.   EXPERIMENTAL NEUROLOGY

Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors

(2014) Poorval M. Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

(2014) Rachael Natrajan et al.   JOURNAL OF PATHOLOGY

Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity

(2013) I. Bajrami et al.   CANCER RESEARCH

Cyclin K-containing Kinase Complexes Maintain Self-renewal in Murine Embryonic Stem Cells

(2012) Qian Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II

(2012) S.- W. G. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Genome profiling of ERBB2-amplified breast cancers

(2010) Fabrice Sircoulomb et al.   BMC CANCER

Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

(2010) Z. J. Zang et al.   CANCER RESEARCH

Homologous recombination in DNA repair and DNA damage tolerance

(2008) Xuan Li et al.   CELL RESEARCH

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

(2008) Z. Ullah et al.   GENES & DEVELOPMENT