ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis

A potential role for SerpinA3N in acetaminophen-induced hepatotoxicity

(2021) Melanie Tran et al.   MOLECULAR PHARMACOLOGY

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

(2021) Wiramon Rungratanawanich et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease

(2021) Jacob W. Ballway et al.   Antioxidants

Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes’ toxicity

(2020) Che-Hong Chen et al.   EBioMedicine

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP 2E1‐Mediated Oxidative and Nitrative Stress

(2019) Young‐Eun Cho et al.   HEPATOLOGY

Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1

(2019) Liya Chen et al.   Redox Biology

Intestinal Microbial Products From Alcohol‐Fed Mice Contribute to Intestinal Permeability and Peripheral Immune Activation

(2019) Derrick R. Samuelson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis

(2019) Pinfang Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytochrome P450S and Alcoholic Liver Disease

(2018) Yongke Lu et al.   CURRENT PHARMACEUTICAL DESIGN

Alda-1, an ALDH2 activator, protects against hepatic ischemia/reperfusion injury in rats via inhibition of oxidative stress

(2018) Tao Zhang et al.   FREE RADICAL RESEARCH

Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury

(2018) Young-Eun Cho et al.   JOURNAL OF HEPATOLOGY

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

(2018) Arnau Panisello-Roselló et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress

(2018) Young-Eun Cho et al.   Redox Biology

ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties

(2018) G. Nannelli et al.   Oxidative Medicine and Cellular Longevity

Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)

(2018) Wiramon Rungratanawanich et al.   Nutrients

Lychee (Litchi chinensis Sonn.) Pulp Phenolic Extract Provides Protection against Alcoholic Liver Injury in Mice by Alleviating Intestinal Microbiota Dysbiosis, Intestinal Barrier Dysfunction, and Liver Inflammation

(2017) Juan Xiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A role for the peripheral immune system in the development of alcohol use disorders?

(2017) Philippe de Timary et al.   NEUROPHARMACOLOGY

Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation

(2017) Suthat Liangpunsakul et al.   Scientific Reports

Alcoholic Liver Disease in Asia, Europe, and North America

(2016) Suthat Liangpunsakul et al.   GASTROENTEROLOGY

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Serum TNF-α, GTH and MDA of high-fat diet-induced obesity and obesity resistant rats

(2016) Peixian Wu et al.   SAUDI PHARMACEUTICAL JOURNAL

ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

(2015) Kamaljit K. Chaudhry et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology

(2015) Brian C. Jackson et al.   Expert Opinion on Drug Metabolism & Toxicology

Even free radicals should follow some rules: A Guide to free radical research terminology and methodology

(2015) Henry Jay Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury

(2015) Sehwan Jang et al.   Redox Biology

Ethanol Reduces Lifespan, Body Weight, and Serum Alanine Aminotransferase Level ofAldehyde Dehydrogenase 2Knockout Mouse

(2014) Akiko Matsumoto et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice

(2014) Hyo-Jung Kwon et al.   HEPATOLOGY

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

(2014) Che-Hong Chen et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications

(2014) Byoung-Joon Song et al.   Redox Biology

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness

(2014) Christopher B. Forsyth et al.   Redox Biology

CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

(2013) Mohamed A. Abdelmegeed et al.   FREE RADICAL BIOLOGY AND MEDICINE

High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner

(2013) Eric K. Long et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aqueous extract of Artemisia capillaris exerts hepatoprotective action in alcohol–pyrazole-fed rat model

(2013) Min-Kyung Choi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alcohol Metabolism

(2012) Arthur I. Cederbaum   Clinics in Liver Disease

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(2012) Jianquan Liao et al.   MOLECULAR MEDICINE

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

(2012) Netanya G. Sandler et al.   NATURE REVIEWS MICROBIOLOGY

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gut Microbiota, Intestinal Permeability, Obesity-Induced Inflammation, and Liver Injury

(2011) Thomas H. Frazier et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

(2011) Byoung-Joon Song et al.   Journal of Proteomics

Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases

(2010) Heng Ma et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Methods for detection and measurement of hydrogen peroxide inside and outside of cells

(2010) Sue Goo Rhee et al.   MOLECULES AND CELLS

Alcoholic liver disease and the gut-liver axis

(2010) Gyongyi Szabo   WORLD JOURNAL OF GASTROENTEROLOGY

Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development

(2010) H Joe Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Intestinal Dysbiosis: A Possible Mechanism of Alcohol-Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

(2009) Ece Mutlu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice

(2009) Hsu-Sheng Yu et al.   TOXICOLOGY MECHANISMS AND METHODS

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

(2009) Philip J Brooks et al.   PLOS MEDICINE

Effect of Alcohol on miR-212 Expression in Intestinal Epithelial Cells and Its Potential Role in Alcoholic Liver Disease

(2008) Yueming Tang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

(2008) Satori A Marchitti et al.   Expert Opinion on Drug Metabolism & Toxicology

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

(2008) Ali Keshavarzian et al.   JOURNAL OF HEPATOLOGY

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE