Review of Quantitative Methods for the Detection of Alzheimer’s Disease with Positron Emission Tomography

Identification and validation of Alzheimer’s disease-related metabolic brain pattern in biomarker confirmed Alzheimer’s dementia patients

(2022) Matej Perovnik et al.   Scientific Reports

Alzheimer’s disease pattern derived from relative cerebral flow as an alternative for the metabolic pattern using SSM/PCA

(2022) Débora E. Peretti et al.   EJNMMI Research

Mapping the association between tau-PET and Aβ-amyloid-PET using deep learning

(2022) Gihan P. Ruwanpathirana et al.   Scientific Reports

Deep transfer learning for alzheimer neurological disorder detection

(2021) Abida Ashraf et al.   MULTIMEDIA TOOLS AND APPLICATIONS

Brain [F-18]FDG PET for Clinical Dementia Workup: Differential Diagnosis of Alzheimer's Disease and Other Types of Dementing Disorders

(2021) Satoshi Minoshima et al.   SEMINARS IN NUCLEAR MEDICINE

Machine Learning for Diagnosis of AD and Prediction of MCI Progression From Brain MRI Using Brain Anatomical Analysis Using Diffeomorphic Deformation

(2021) Ali Haidar Syaifullah et al.   Frontiers in Neurology

Quantitative Radiomic Features as New Biomarkers for Alzheimer’s Disease: An Amyloid PET Study

(2021) Yanhui Ding et al.   CEREBRAL CORTEX

PET Neuroimaging of Alzheimer's Disease: Radiotracers and Their Utility in Clinical Research

(2021) Weiqi Bao et al.   Frontiers in Aging Neuroscience

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease

(2021) Rik Ossenkoppele et al.   JAMA Neurology

Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective

(2021) Maria Ricci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Talking points for physicians, patients and caregivers considering Aduhelm® infusion and the accelerated pathway for its approval by the FDA

(2021) Sam Gandy et al.   Molecular Neurodegeneration

Spatial metabolic profiles to discriminate dementia with Lewy bodies from Alzheimer disease

(2020) Tomomichi Iizuka et al.   JOURNAL OF NEUROLOGY

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

(2020) Botond Penke et al.   MOLECULES

Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer’s disease

(2020) Mark E. Schmidt et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Generative adversarial networks

(2020) Ian Goodfellow et al.   COMMUNICATIONS OF THE ACM

Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

(2020) Audrey P. Fan et al.   NEUROIMAGE

Deep learning detection of informative features in tau PET for Alzheimer’s disease classification

(2020) Taeho Jo et al.   BMC BIOINFORMATICS

Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease

(2019) Omar A. Halawa et al.   Alzheimers Research & Therapy

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

(2019) Yogatheesan Varatharajah et al.   Scientific Reports

Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

(2019) Frederik J. R. Rombouts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantifying brain metabolism from FDG‐PET images into a probability of Alzheimer's dementia score

(2019) Evangeline Yee et al.   HUMAN BRAIN MAPPING

Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease

(2019) Edmond Teng et al.   NEUROBIOLOGY OF AGING

Topographical Heterogeneity of Alzheimer’s Disease Based on MR Imaging, Tau PET, and Amyloid PET

(2019) Seun Jeon et al.   Frontiers in Aging Neuroscience

Diagnosis and Management of Dementia: Review

(2019) Zoe Arvanitakis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Prevalence of Dementia: A Systematic Review and Meta-Analysis

(2019) Qing Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease

(2018) Jennifer L. Whitwell et al.   Alzheimers & Dementia

18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia

(2018) Tatsuya Higashi et al.   ANNALS OF NUCLEAR MEDICINE

Predicting cognitive decline with deep learning of brain metabolism and amyloid imaging

(2018) Hongyoon Choi et al.   BEHAVIOURAL BRAIN RESEARCH

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

(2018) Ruth Knight et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Multiscale deep neural network based analysis of FDG-PET images for the early diagnosis of Alzheimer’s disease

(2018) Donghuan Lu et al.   MEDICAL IMAGE ANALYSIS

DeepNAT: Deep convolutional neural network for segmenting neuroanatomy

(2018) Christian Wachinger et al.   NEUROIMAGE

Classification of Alzheimer’s Disease by Combination of Convolutional and Recurrent Neural Networks Using FDG-PET Images

(2018) Manhua Liu et al.   Frontiers in Neuroinformatics

The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging

(2018) Enrica Cavedo et al.   JOURNAL OF ALZHEIMERS DISEASE

Machine learning identified an Alzheimer’s disease-related FDG-PET pattern which is also expressed in Lewy body dementia and Parkinson’s disease dementia

(2018) Audrey Katako et al.   Scientific Reports

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study

(2018) Takamasa Yokoi et al.   Frontiers in Aging Neuroscience

An Automated Pipeline for the Analysis of PET Data on the Cortical Surface

(2018) Arnaud Marcoux et al.   Frontiers in Neuroinformatics

Prognosis of conversion of mild cognitive impairment to Alzheimer's dementia by voxel-wise Cox regression based on FDG PET data

(2018) Arnd Sörensen et al.   NeuroImage-Clinical

A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain

(2018) Yiming Ding et al.   RADIOLOGY

The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment

(2017) Sanne K Meles et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Preclinical Evaluation of 18 F-JNJ64349311, a Novel PET Tracer for Tau Imaging

(2017) Lieven Declercq et al.   JOURNAL OF NUCLEAR MEDICINE

Validation of 18F–FDG-PET Single-Subject Optimized SPM Procedure with Different PET Scanners

(2017) Luca Presotto et al.   NEUROINFORMATICS

Interpreting Biomarker Results in Individual Patients With Mild Cognitive Impairment in the Alzheimer’s Biomarkers in Daily Practice (ABIDE) Project

(2017) Ingrid S. van Maurik et al.   JAMA Neurology

Brain region ranking for 18FDG-PET computer-aided diagnosis of Alzheimer's disease

(2016) I. Garali et al.   Biomedical Signal Processing and Control

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture

(2016) Lingzhong Fan et al.   CEREBRAL CORTEX

Deep Feature Extraction and Classification of Hyperspectral Images Based on Convolutional Neural Networks

(2016) Yushi Chen et al.   IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING

Suspected non-Alzheimer disease pathophysiology — concept and controversy

(2016) Clifford R. Jack et al.   Nature Reviews Neurology

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Regional tau deposition measured by [18F]THK5317 positron emission tomography is associated to cognition via glucose metabolism in Alzheimer’s disease

(2016) Laure Saint-Aubert et al.   Alzheimers Research & Therapy

Medical costs of Alzheimer's disease misdiagnosis among US Medicare beneficiaries

(2015) Craig A. Hunter et al.   Alzheimers & Dementia

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

(2015) William E. Klunk et al.   Alzheimers & Dementia

Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation

(2015) A. P. Nayate et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

(2015) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

Deep learning

(2015) Yann LeCun et al.   NATURE

Quantitative imaging of protein targets in the human brain with PET

(2015) Roger N Gunn et al.   PHYSICS IN MEDICINE AND BIOLOGY

On Pixel-Wise Explanations for Non-Linear Classifier Decisions by Layer-Wise Relevance Propagation

(2015) Sebastian Bach et al.   PLoS One

Longitudinal Assessment of Tau Pathology in Patients with Alzheimer’s Disease Using [18F]THK-5117 Positron Emission Tomography

(2015) Aiko Ishiki et al.   PLoS One

Brain PET in the Diagnosis of Alzheimer’s Disease

(2014) Charles Marcus et al.   CLINICAL NUCLEAR MEDICINE

The Alzheimer’s Disease-Related Glucose Metabolic Brain Pattern

(2014) Laura Teune et al.   Current Alzheimer Research

A Standardized [18F]-FDG-PET Template for Spatial Normalization in Statistical Parametric Mapping of Dementia

(2014) Pasquale Anthony Della Rosa et al.   NEUROINFORMATICS

Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting

(2014) Daniela Perani et al.   NeuroImage-Clinical

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

The history of cerebral PET scanning: From physiology to cutting-edge technology

(2013) L. H. Portnow et al.   NEUROLOGY

BrainNet Viewer: A Network Visualization Tool for Human Brain Connectomics

(2013) Mingrui Xia et al.   PLoS One

Amyloid Imaging With Carbon 11–Labeled Pittsburgh Compound B for Traumatic Brain Injury

(2013) Young T. Hong et al.   JAMA Neurology

Worldwide Alzheimer’s Disease Neuroimaging Initiative

(2012) Maria C. Carrillo et al.   Alzheimers & Dementia

Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET

(2012) Rik Ossenkoppele et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

How golden is the gold standard of neuropathology in dementia?

(2011) Philip Scheltens et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias

(2011) V. L. Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia

(2011) William E. Klunk   NEUROBIOLOGY OF AGING

Amyloid imaging in prodromal Alzheimer's disease

(2011) Rik Ossenkoppele et al.   Alzheimers Research & Therapy

Alzheimer's Disease Neuroimaging Initiative in Europe

(2010) Giovanni B. Frisoni   Alzheimers & Dementia

Japanese Alzheimer's Disease Neuroimaging Initiative: Present status and future

(2010) Takeshi Iwatsubo   Alzheimers & Dementia

Computer aided diagnosis of Alzheimer’s disease using component based SVM

(2010) I.A. Illán et al.   APPLIED SOFT COMPUTING

Molecular tracers for the PET and SPECT imaging of disease

(2010) Sally L. Pimlott et al.   CHEMICAL SOCIETY REVIEWS

18F-FDG PET imaging analysis for computer aided Alzheimer’s diagnosis☆

(2010) I.A. Illán et al.   INFORMATION SCIENCES

The use of PET in Alzheimer disease

(2010) Agneta Nordberg et al.   Nature Reviews Neurology

Scaled subprofile modeling of resting state imaging data in Parkinson's disease: Methodological issues

(2010) Phoebe G. Spetsieris et al.   NEUROIMAGE

Clinicopathological Concordance in Dementia Diagnostics

(2009) Hans Brunnström et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Computer-aided diagnosis of Alzheimer’s type dementia combining support vector machines and discriminant set of features

(2009) J. Ramírez et al.   INFORMATION SCIENCES

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Comparison of amyloid plaque contrast generated byT2-weighted,T2*-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease

(2009) Ryan Chamberlain et al.   MAGNETIC RESONANCE IN MEDICINE

Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease

(2009) A. Drzezga et al.   NEUROLOGY

Conversion of amyloid positive and negative MCI to AD over 3 years: An 11C-PIB PET study

(2009) A. Okello et al.   NEUROLOGY

Alzheimer's Disease Neuroimaging Initiative (ADNI): Clinical characterization

(2009) R. C. Petersen et al.   NEUROLOGY

Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine

(2008) R Schmidt et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

[11C]PIB-amyloid binding and levels of Aβ40 and Aβ42 in postmortem brain tissue from Alzheimer patients

(2008) Marie M. Svedberg et al.   NEUROCHEMISTRY INTERNATIONAL

SPM-based count normalization provides excellent discrimination of mild Alzheimer's disease and amnestic mild cognitive impairment from healthy aging☆

(2008) I YAKUSHEV et al.   NEUROIMAGE