BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity

EGFR Mutation and 11q13 Amplification Are Potential Predictive Biomarkers for Immunotherapy in Head and Neck Squamous Cell Carcinoma

(2022) Shengjin Dou et al.   Frontiers in Immunology

The Potential Predictive Biomarkers for Advanced Hepatocellular Carcinoma Treated With Anti-Angiogenic Drugs in Combination With PD-1 Antibody

(2022) Chenxi Liu et al.   Frontiers in Immunology

In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer

(2022) Peng Ji et al.   Science Advances

Evaluation of a nationwide Dutch guideline to detect Lynch syndrome in patients with endometrial cancer

(2021) A.S. Tjalsma et al.   GYNECOLOGIC ONCOLOGY

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy

(2021) Ajaz A. Bhat et al.   Molecular Cancer

CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer

(2021) Moran Yang et al.   Journal for ImmunoTherapy of Cancer

Therapeutic Targeting of the Tumor Microenvironment

(2021) Leire Bejarano et al.   Cancer Discovery

Chronically elevated branched chain amino acid levels are pro-arrhythmic

(2021) Vincent Portero et al.   CARDIOVASCULAR RESEARCH

Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

(2021) Huadong Lai et al.   INTERNATIONAL JOURNAL OF CANCER

5mC regulator-mediated molecular subtypes depict the hallmarks of the tumor microenvironment and guide precision medicine in bladder cancer

(2021) Jiao Hu et al.   BMC Medicine

A Novel TGF-β Risk Score Predicts the Clinical Outcomes and Tumour Microenvironment Phenotypes in Bladder Cancer

(2021) Zhi Liu et al.   Frontiers in Immunology

A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer

(2020) Joan Miguel Romero et al.   CLINICAL CANCER RESEARCH

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

Acquired Resistance to Immune Checkpoint Inhibitors

(2020) Adam J. Schoenfeld et al.   CANCER CELL

Randomized Double-Blind Phase II Study of Maintenance Pembrolizumab Versus Placebo After First-Line Chemotherapy in Patients With Metastatic Urothelial Cancer

(2020) Matthew D. Galsky et al.   JOURNAL OF CLINICAL ONCOLOGY

Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial

(2020) Matthew D Galsky et al.   LANCET

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

(2020) Bo Zhang et al.   Molecular Cancer

The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

(2020) Xueping Wang et al.   Molecular Cancer

TIMER2.0 for analysis of tumor-infiltrating immune cells

(2020) Taiwen Li et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

(2020) Muhammad Zaeem Noman et al.   Science Advances

Treatment of muscle‐invasive and advanced bladder cancer in 2020

(2020) Vaibhav G. Patel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Impact of Molecular Subtyping and Immune Infiltration on Pathological Response and Outcome Following Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer

(2020) Andrea Necchi et al.   EUROPEAN UROLOGY

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

(2020) Kang Wang et al.   CELL DEATH AND DIFFERENTIATION

Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma

(2020) Anastasia Makarevic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma

(2020) Thomas Powles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

(2020) Zhaohui Chen et al.   Nature Communications

Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma

(2020) Yuanhao Chang et al.   Frontiers in Immunology

TISIDB: an integrated repository portal for tumor-immune system interactions

(2019) Beibei Ru et al.   BIOINFORMATICS

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Management of metastatic bladder cancer

(2019) Rosa Nadal et al.   CANCER TREATMENT REVIEWS

Biomarkers for platinum sensitivity in bladder cancer: are we there yet?

(2019) Nirmish Singla et al.   Translational Andrology and Urology

A Consensus Molecular Classification of Muscle-invasive Bladder Cancer

(2019) Aurélie Kamoun et al.   EUROPEAN UROLOGY

Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy

(2019) Yan-ping Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity

(2018) Nathan Karin et al.   CYTOKINE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

The Tumor Mutational Burden of Chinese Advanced Cancer Patients Estimated by a 381-cancer-gene Panel

(2018) Wu Zhuang et al.   Journal of Cancer

Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors

(2018) Tuan Zea Tan et al.   EUROPEAN UROLOGY

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

(2018) Saman Maleki Vareki   Journal for ImmunoTherapy of Cancer

Genomic Differences Between “Primary” and “Secondary” Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy

(2018) Eugene J. Pietzak et al.   EUROPEAN UROLOGY

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

(2017) Galina Khemlina et al.   Molecular Cancer

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry

(2017) Hongjuan Zhao et al.   Clinical Epigenetics

A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas

(2016) Claire Carleton et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Practical guidance for mismatch repair-deficiency testing in endometrial cancer

(2016) E. Stelloo et al.   ANNALS OF ONCOLOGY

ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy

(2016) Floris H. Groenendijk et al.   EUROPEAN UROLOGY

Biomarkers for precision medicine in bladder cancer

(2016) Takahiro Kojima et al.   International Journal of Clinical Oncology

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

(2016) Geoffrey T Gibney et al.   LANCET ONCOLOGY

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Genetic subtypes of invasive bladder cancer

(2015) David J. McConkey et al.   CURRENT OPINION IN UROLOGY

Cisplatin selectively downregulated the frequency and immunoinhibitory function of myeloid-derived suppressor cells in a murine B16 melanoma model

(2015) Xiang Huang et al.   IMMUNOLOGIC RESEARCH

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

(2014) E. M. Van Allen et al.   Cancer Discovery

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Changes in the immune cell population and cell proliferation in peripheral blood after gemcitabine-based chemotherapy for pancreatic cancer

(2013) Y. Homma et al.   Clinical & Translational Oncology

Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment

(2013) Thomas F Gajewski et al.   CURRENT OPINION IN IMMUNOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo

(2012) Connie Jackaman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

(2011) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment

(2010) Thomas F Gajewski et al.   CURRENT OPINION IN IMMUNOLOGY

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

(2009) H. Pelicano et al.   CANCER RESEARCH

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

WIN55,212-2 Inhibits Production of CX3CL1 by Human Astrocytes: Involvement of p38 MAP Kinase

(2009) W. S. Sheng et al.   Journal of Neuroimmune Pharmacology