Uncovering metabolism in rhabdomyosarcoma

SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma

(2015) Davide Martino Coda et al.   CELL CYCLE

Clonality and Evolutionary History of Rhabdomyosarcoma

(2015) Li Chen et al.   PLoS Genetics

Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options

(2015) J M Loupe et al.   Oncogenesis

Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism?

(2015)   Oncotarget

NRF2 and p53: Januses in cancer?

(2015) Barak Rotblat et al.   Oncotarget

A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: Results of a Sarcoma Alliance

(2014) Alberto S. Pappo et al.   CANCER

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma

(2014) V. Thalhammer et al.   CANCER RESEARCH

Zebrafish as a model to assess cancer heterogeneity, progression and relapse

(2014) J. S. Blackburn et al.   Disease Models & Mechanisms

Lineage of origin in rhabdomyosarcoma informs pharmacological response

(2014) J. Abraham et al.   GENES & DEVELOPMENT

Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: A report from the children's oncology group

(2014) Lars M. Wagner et al.   PEDIATRIC BLOOD & CANCER

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

(2014) J. F. Shern et al.   Cancer Discovery

Rhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies

(2014) S. Hettmer et al.   Cold Spring Harbor Perspectives in Medicine

Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma

(2014) Ken Kikuchi et al.   PLoS Genetics

Classification of Rhabdomyosarcoma and Its Molecular Basis

(2013) David M. Parham et al.   ADVANCES IN ANATOMIC PATHOLOGY

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

(2013) Xiang Chen et al.   CANCER CELL

RAS and ROS in Rhabdomyosarcoma

(2013) Minsi Zhang et al.   CANCER CELL

Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis

(2013) Mehtap Kilic-Eren et al.   Cancer Cell International

Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma

(2013) Monika Katharina Guenther et al.   CANCER LETTERS

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation

(2013) Peng Jiang et al.   CELL CYCLE

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

An open-label, phase 2 study evaluating the efficacy and safety of the anti-IGF-1R antibody cixutumumab in patients with previously treated advanced or metastatic soft-tissue sarcoma or Ewing family of tumours

(2013) P. Schöffski et al.   EUROPEAN JOURNAL OF CANCER

Mechanisms of impaired differentiation in rhabdomyosarcoma

(2013) Charles Keller et al.   FEBS Journal

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

p73 regulates serine biosynthesis in cancer

(2013) I Amelio et al.   ONCOGENE

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group

(2013) Brenda Weigel et al.   PEDIATRIC BLOOD & CANCER

PAX-FOXO1fusion status drives unfavorable outcome for children with rhabdomyosarcoma: A children's oncology group report

(2013) Stephen X. Skapek et al.   PEDIATRIC BLOOD & CANCER

Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: A children's oncology group study

(2013) Rochelle Bagatell et al.   PEDIATRIC BLOOD & CANCER

IL-4 receptor blockade abrogates satellite cell: Rhabdomyosarcoma fusion and prevents tumor establishment

(2013) Guangheng Li et al.   STEM CELLS

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor Cells

(2013) Jordan M. Blum et al.   Cell Reports

Human Rhabdomyosarcoma Cell Lines for Rhabdomyosarcoma Research: Utility and Pitfalls

(2013) Ashley R. P. Hinson et al.   Frontiers in Oncology

Cellular Heterogeneity and Molecular Evolution in Cancer

(2012) Vanessa Almendro et al.   Annual Review of Pathology-Mechanisms of Disease

Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR–dependent motility in alveolar rhabdomyosarcoma cells

(2012) Lingling Liu et al.   BMC CANCER

A Mouse Model of Rhabdomyosarcoma Originating from the Adipocyte Lineage

(2012) Mark E. Hatley et al.   CANCER CELL

In Vivo Imaging of Tumor-Propagating Cells, Regional Tumor Heterogeneity, and Dynamic Cell Movements in Embryonal Rhabdomyosarcoma

(2012) Myron S. Ignatius et al.   CANCER CELL

Intratumor Heterogeneity: Evolution through Space and Time

(2012) C. Swanton   CANCER RESEARCH

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell

(2012) Mathivanan Jothi et al.   CELL CYCLE

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid

(2012) Satish C. Kalhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAX3/FOXO1Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification

(2012) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Myogenic Tumors in Children and Adolescents

(2012) David M. Parham et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Phase 2 trial of pemetrexed in children and adolescents with refractory solid tumors: A Children's Oncology Group study

(2012) Anne B. Warwick et al.   PEDIATRIC BLOOD & CANCER

Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)

(2012) Puspa R. Pandey et al.   Recent Patents on Anti-Cancer Drug Discovery

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Update on rhabdomyosarcoma

(2012) Roshni Dasgupta et al.   Seminars in Pediatric Surgery

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

Alveolar rhabdomyosarcoma – The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis

(2012) Amy D Marshall et al.   Skeletal Muscle

Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

(2011) Brian P. Rubin et al.   CANCER CELL

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

(2011) S. Ramirez-Peinado et al.   CANCER RESEARCH

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

(2011) R. Tonelli et al.   CLINICAL CANCER RESEARCH

Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways

(2011) N. Shukla et al.   CLINICAL CANCER RESEARCH

Building the bridge between rhabdomyosarcoma in children, adolescents and young adults: The road ahead

(2011) J. Carlijn Van Gaal et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children’s Oncology Group

(2011) Sylvain Baruchel et al.   EUROPEAN JOURNAL OF CANCER

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells

(2011) S. Hettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targets for cancer therapy in childhood sarcomas

(2010) Marco Wachtel et al.   CANCER TREATMENT REVIEWS

The role of p53 in glucose metabolism

(2010) Eric C Cheung et al.   CURRENT OPINION IN CELL BIOLOGY

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

(2010) Daniel Williamson et al.   JOURNAL OF CLINICAL ONCOLOGY

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005

(2009) Simona Ognjanovic et al.   CANCER

Metabolic transformation in cancer

(2009) D. A. Tennant et al.   CARCINOGENESIS

Selective upregulation of interleukin-8 by human rhabdomyosarcomas in response to hypoxia: therapeutic implications

(2009) Marcin Wysoczynski et al.   INTERNATIONAL JOURNAL OF CANCER

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model

(2009) Rashmi Chugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Sarcomas Across the Age Spectrum

(2009) Suzanne L. Wolden et al.   SEMINARS IN RADIATION ONCOLOGY

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Defining the Cooperative Genetic Changes That Temporally Drive Alveolar Rhabdomyosarcoma

(2008) S. Naini et al.   CANCER RESEARCH

Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

(2008) C. E. Cano et al.   CANCER RESEARCH

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: Focus onMYCN as a biologically relevant target

(2008) Gabriela E. Mercado et al.   GENES CHROMOSOMES & CANCER

Hypoxia-Inducible Factor-Dependent Degeneration, Failure, and Malignant Transformation of the Heart in the Absence of the von Hippel-Lindau Protein

(2008) L. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY