SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma

Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading

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The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis

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Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers

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Cyclin D1 is a major target of miR-206 in cell differentiation and transformation

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

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Smyd1b is required for skeletal and cardiac muscle function in zebrafish

(2013) Huiqing Li et al.   MOLECULAR BIOLOGY OF THE CELL

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

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JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells

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Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma

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Alternative Polyadenylation Mediates MicroRNA Regulation of Muscle Stem Cell Function

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microRNAs in skeletal muscle differentiation and disease

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Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation

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Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma

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Snail Regulates MyoD Binding-Site Occupancy to Direct Enhancer Switching and Differentiation-Specific Transcription in Myogenesis

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A Novel YY1-miR-1 Regulatory Circuit in Skeletal Myogenesis Revealed by Genome-Wide Prediction of YY1-miRNA Network

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Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer

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miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells

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Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

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Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State

(2011) M.-H. Lee et al.   CANCER RESEARCH

Deregulated expression of miR-26a and Ezh2 in Rhabdomyosarcoma

(2011) Roberta Ciarapica et al.   CELL CYCLE

Micro-orchestrating differentiation in cancer

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Stuck in a balancing act

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Targeting cancer metabolism – aiming at a tumour's sweet-spot

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TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4

(2011) Catherine E. Winbanks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly

(2011) Yazhong Tao et al.   JOURNAL OF CELL BIOLOGY

The myosin-interacting protein SMYD1 is essential for sarcomere organization

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MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality

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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

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Smyd1b_tv1, a Key Regulator of Sarcomere Assembly, Is Localized on the M-Line of Skeletal Muscle Fibers

(2011) Huiqing Li et al.   PLoS One

MicroRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway

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Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture

(2010) Nualpun Sirinupong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

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miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7

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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration

(2010) C. Y. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

MicroRNA-1/206 Targets c-Metand Inhibits Rhabdomyosarcoma Development

(2009) Dongsheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-206 Targetsnotch3, Activates Apoptosis, and Inhibits Tumor Cell Migration and Focus Formation

(2009) Guisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program

(2009) Mark A. Gillespie et al.   JOURNAL OF CELL BIOLOGY

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation

(2009) Riccardo Taulli et al.   JOURNAL OF CLINICAL INVESTIGATION

SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin

(2009) D. Li et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-206: The skeletal muscle-specific myomiR

(2008) J MCCARTHY   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

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