The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

(2014) Helen Walden et al.   Annual Review of Biophysics

Stress and DNA repair biology of the Fanconi anemia pathway

(2014) S. Longerich et al.   BLOOD

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

(2014) H. Holstege et al.   GENOME RESEARCH

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Divisional History and Hematopoietic Stem Cell Function during Homeostasis

(2014) Jiajing Qiu et al.   Stem Cell Reports

Fetal origins of hematopoietic failure in a murine model of Fanconi anemia

(2013) A. N. Kamimae-Lanning et al.   BLOOD

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

(2013) C. Gekas et al.   BLOOD

Why does the bone marrow fail in Fanconi anemia?

(2013) J. I. Garaycoechea et al.   BLOOD

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

(2013) A. Hira et al.   BLOOD

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

(2011) Carolien M Woolthuis et al.   CURRENT OPINION IN IMMUNOLOGY

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

(2011) Hitoshi Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage

(2010) A. Tulpule et al.   BLOOD

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

(2010) Patrizia Vinciguerra et al.   JOURNAL OF CLINICAL INVESTIGATION

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-  on Fanconi anemia hematopoietic stem and progenitor cells

(2009) M. D. Milsom et al.   BLOOD

Mouse models of Fanconi anemia

(2009) Kalindi Parmar et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL