Review
Biotechnology & Applied Microbiology
Manoj Kumar Yadav, Indu Kumari, Bijender Singh, Krishna Kant Sharma, Santosh Kumar Tiwari
Summary: Probiotics are an economical and safe alternative for treating chronic diseases and improving human health. They modulate the host immunity and protect against infectious and non-infectious diseases. Additionally, prebiotics and non-digestible food substances promote the growth of probiotics and human health through modulation of gut microbiota and immune system.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca De Filippis, Alessia Esposito, Danilo Ercolini
Summary: Currently available probiotics are limited in microbial species, but recent research suggests that the gut microbiome holds potential for beneficial microbes. Researchers are focusing on identifying and testing new gut-origin microbial strains for the development of next-generation probiotics. While some of these strains show promise for preventing and treating chronic diseases, human studies are lacking and regulatory approval is rare. Furthermore, challenges remain in cultivation and storage methods for oxygen-sensitive bacteria before wide market application.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Chemistry, Analytical
Ting Wang, Wang Ziwei, Bai Linlin, Zhang Xingcai, Jia Feng, Cheng Qian, Wang Yongming, Rui Wang
Summary: Accurate diagnosis of human diseases is crucial and traditional molecular detection methods have limitations. The rapidly evolving CRISPR/Cas systems have revolutionized molecular diagnostics by providing a low-cost, versatile, and powerful toolbox. This review introduces the working principle of the CRISPR toolbox and various detection methods for both infectious and non-infectious diseases, with a focus on single nucleotide polymorphism detection. Challenges and future breakthrough applications in CRISPR molecular diagnostics are also discussed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Immunology
Mecklin V. Ragan, Samantha J. Wala, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: This article introduces a new delivery system for L. reuteri that enhances the efficacy of the probiotic by inducing biofilm formation. The study shows promising results in rat and mouse models, demonstrating the preventive and therapeutic effects of L. reuteri in its biofilm state. Furthermore, an ongoing clinical trial may support the future use of L. reuteri in preventing NEC in preterm infants.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Food Science & Technology
Manorama Kumari, Parul Singh, Basavaprabhu H. Nataraj, Anusha Kokkiligadda, Harshita Naithani, Syed Azmal Ali, Pradip. Behare, Ravinder Nagpal
Summary: Emerging evidence and understanding of the microbiome have identified beneficial commensals known as next-generation probiotics. Specific dietary interventions can modulate the abundance and activity of these beneficial bacteria in the gut, and combining specific probiotic-targeted diets can enhance their effectiveness.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Marcella Pesce, Luisa Seguella, Alessandro Del Re, Jie Lu, Irene Palenca, Chiara Corpetti, Sara Rurgo, Walter Sanseverino, Giovanni Sarnelli, Giuseppe Esposito
Summary: Engineered probiotics are a cutting-edge therapy in treating intestinal inflammatory diseases, offering a new strategy with therapeutically operative molecules. Traditional treatments have side effects, prompting the search for new and effective therapies as a global goal in research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Tejinder Pal Singh, Basavaprabhu Haranahalli Natraj
Summary: The gut microbiome plays a crucial role in host health, with potential for manipulation to control individual health and design personalized medicine. Next-generation probiotics (NGPs) show promise as new therapeutic agents, but their unique characteristics and growth requirements present challenges for researchers and regulatory agencies.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Isabella J. McLoughlin, Eva M. Wright, John R. Tagg, Rohit Jain, John D. F. Hale
Summary: The skin, as the largest organ in the human body, plays a crucial role in our survival by supporting various functions. Dysbiosis in the microbial populations on the skin can lead to skin diseases, prompting research in medical dermatology and cosmetic industries on modulating the skin microbiome for better skin health.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Review
Nutrition & Dietetics
Javad Bazeli, Zarrin Banikazemi, Michael R. R. Hamblin, Reza Sharafati Chaleshtori
Summary: Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially when ingested. They can cause various adverse effects, but limited information is available on how probiotics may protect against PS toxicity. However, studies suggest that probiotics can overcome the toxicity of polystyrene nanoplastics and microplastics in humans, although more research is needed before clinical recommendations can be made.
FRONTIERS IN NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Jingpeng Yang, Yanan Li, Zhiqiang Wen, Wenzheng Liu, Lingtong Meng, He Huang
Summary: Oscillospira, a bacterium widely present in the intestines, is closely associated with obesity and health. It has the potential to produce beneficial short-chain fatty acids and could be a candidate for next-generation probiotics.
Article
Food Science & Technology
Anders Meyer Torp, Martin Iain Bahl, Anja Boisen, Tine Rask Licht
Summary: This article reviews the challenges in developing next generation probiotic products, evaluates the current microbial processing and delivery techniques for oxygen-sensitive probiotics, and discusses possible process optimizations. The current microbial processing techniques are not suitable for next generation probiotics, necessitating the need for optimization or entirely novel approaches. Oral delivery of live next generation probiotics is poorly studied, suggesting the potential for novel delivery vehicles such as microparticles and microdevices.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Food Science & Technology
Priyanka Suthar, Satish Kumar, Vikas Kumar, Vishal Sharma, Atul Dhiman
Summary: Consumers' interest in health promoting foods has led to the development of novel biological compounds with diverse health benefits in the food industry. Postbiotics, as potential functional food compounds, have been well-studied in terms of their interaction, production, processing, and safety. The review explores the challenges and opportunities in improving growth mediums, cell lysis, extraction, characterization, stability, and applications of postbiotics in both the food and pharma industry, along with market trends, success stories, and safety concerns. Extensive investigations and clinical documentation have validated the physiological benefits and additional bioactivity of postbiotics, emphasizing the importance of documenting their bioactivity and safety.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Alfonso Torres-Sanchez, Alicia Ruiz-Rodriguez, Pilar Ortiz, Maria Alejandra Moreno, Antonis Ampatzoglou, Agnieszka Gruszecka-Kosowska, Mercedes Monteoliva-Sanchez, Margarita Aguilera
Summary: Variation of gut microbiota in metabolic diseases is related to dysbiosis induced by exposure to Microbiota Disrupting Chemicals (MDCs). Recent studies have focused on identifying key targets involved in the severity of the host disease triggered by xenobiotics. Understanding the triad of xenobiotic-microbiota-metabolic diseases can help prevent or treat health imbalances by identifying beneficial microbe taxa and developing mitigation strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Agriculture, Multidisciplinary
Arpita Das, Rama N. Behera, Ayushi Kapoor, Kiran Ambatipudi
Summary: The symbiotic relationship between probiotic bacteria and humans has numerous health benefits and requires the bacteria's resistance to survive unfavorable gut conditions. Proteins play a crucial role in the interaction between probiotics and the host, modulating the gut microbiome. Current research focuses on precision probiotics for personalized treatment, using metaproteomics and AI/ML algorithms to analyze multiomics data and predict beneficial probiotic features.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Microbiology
Barbara Sionek, Aleksandra Szydlowska, Dorota Zielinska, Katarzyna Neffe-Skocinska, Danuta Kolozyn-Krajewska
Summary: The use of probiotics for human health is increasing. Besides lactic acid bacteria isolated from the human gastrointestinal tract, probiotics can also be derived from unconventional sources, such as fermented food products of animal and plant origin. Recent studies have shown the potential health benefits of next-generation probiotics (NGPs), which include strains isolated from unconventional sources. These NGPs have positive effects on various human health aspects, such as metabolic, gastrointestinal, neurological, cardiovascular, and immune system diseases.
