Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

(2022) Pengcheng Han et al.   CELL

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

(2022) Elisabetta Cameroni et al.   NATURE

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

(2022) Young-Jun Park et al.   SCIENCE

Predicting the mutational drivers of future SARS-CoV-2 variants of concern

(2022) M. Cyrus Maher et al.   Science Translational Medicine

Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater

(2022) Davida S. Smyth et al.   Nature Communications

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

(2022) Allison J. Greaney et al.   PLoS Pathogens

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

(2022) Matthew McCallum et al.   SCIENCE

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

(2022) Kathryn Westendorf et al.   Cell Reports

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5

(2022) Qian Wang et al.   NATURE

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

(2022) Yunlong Cao et al.   NATURE

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

(2022) Tyler N. Starr et al.   SCIENCE

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

(2022) Victoria Stalls et al.   Cell Reports

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

(2022) Neil Bate et al.   PLoS Pathogens

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

(2021) Emma C. Thomson et al.   CELL

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

(2021) Daniel Ellis et al.   Frontiers in Immunology

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

(2021) Jiří Zahradník et al.   Nature Microbiology

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

(2020) Tyler N. Starr et al.   CELL

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

(2020) Allison J. Greaney et al.   Cell Host & Microbe

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

(2018) Tyler N. Starr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations

(2016) Neil Peterman et al.   BMC GENOMICS

Epistasis in protein evolution

(2016) Tyler N. Starr et al.   PROTEIN SCIENCE

Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves

(2016) Rhys M Adams et al.   eLife

Contingency and entrenchment in protein evolution under purifying selection

(2015) Premal Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability-mediated epistasis constrains the evolution of an influenza protein

(2013) Lizhi Ian Gong et al.   eLife