Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress

Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

(2022) Josephine Bock et al.   Cell Reports

Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer

(2022) Oskar Engberg et al.   Science Advances

Distinct classes of misfolded proteins differentially affect the growth of yeast compromised for proteasome function

(2021) Grace D. Burns et al.   FEBS LETTERS

DAXX represents a new type of protein-folding enabler

(2021) Liangqian Huang et al.   NATURE

Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation

(2021) Zhihao Sun et al.   Cell Reports

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates

(2021) Anahita Nejatfard et al.   Cell Reports

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

(2020) Michael L. van de Weijer et al.   MOLECULAR CELL

The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications

(2020) Rachel R. Kandel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The complex life of rhomboid pseudoproteases

(2020) Colin Adrain et al.   FEBS Journal

The structure and function of deubiquitinases: lessons from budding yeast

(2020) Harsha Garadi Suresh et al.   Open Biology

HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation

(2020) Sonya Neal et al.   iScience

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Quality Control of Protein Complex Assembly by a Transmembrane Recognition Factor

(2019) Nivedita Natarajan et al.   MOLECULAR CELL

Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function

(2018) Verena M. Link et al.   CELL

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation

(2018) G. Michael Preston et al.   MOLECULAR CELL

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins

(2018) Sonya Neal et al.   MOLECULAR CELL

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities

(2018) Anežka Tichá et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Cdc48 “Retrochaperone” Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates

(2017) Sonya Neal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

(2016) Ryan D. Baldridge et al.   CELL

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

(2015) Hanneke Hoelen et al.   PLoS One

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation

(2013) Kunio Nakatsukasa et al.   MOLECULAR BIOLOGY OF THE CELL

Evolutionary selection for protein aggregation

(2012) Natalia Sanchez de Groot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking

(2011) Ann Marie Stanley et al.   FEBS LETTERS

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit

(2010) Peera Jaru-Ampornpan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In VitroAnalysis of Hrd1p-mediated Retrotranslocation of Its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase

(2009) Renee M. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

Analysis of Quality Control Substrates in Distinct Cellular Compartments Reveals a Unique Role for Rpn4p in Tolerating Misfolded Membrane Proteins

(2008) Meredith Boyle Metzger et al.   MOLECULAR BIOLOGY OF THE CELL

Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice

(2007) Zhi-Fang Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES