Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

(2022) Elisabetta Cameroni et al.   NATURE

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

(2022) Laura A. VanBlargan et al.   NATURE MEDICINE

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

(2022) Dhiraj Mannar et al.   SCIENCE

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

(2022) James W. Saville et al.   Nature Communications

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

(2022) Riem Gawish et al.   eLife

Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages

(2022) Jingwen Ai et al.   Cell Host & Microbe

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

(2022) Sho Iketani et al.   NATURE

Mutations in SARS-CoV-2 are on the increase against the acquired immunity

(2022) Tomokazu Konishi   PLoS One

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

(2022) Victoria Stalls et al.   Cell Reports

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

(2022) Dhiraj Mannar et al.   Nature Communications

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

(2021) Matthew McCallum et al.   CELL

An NTD supersite of attack

(2021) Shee-Mei Lok   Cell Host & Microbe

Structural impact on SARS-CoV-2 spike protein by D614G substitution

(2021) Jun Zhang et al.   SCIENCE

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

(2021) Xing Zhu et al.   PLOS BIOLOGY

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

(2021) Kun Huang et al.   EBioMedicine

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

(2021) Dapeng Li et al.   CELL

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

(2021) Tyler N. Starr et al.   NATURE

SARS-CoV-2 variants, spike mutations and immune escape

(2021) William T. Harvey et al.   NATURE REVIEWS MICROBIOLOGY

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

(2021) Sophie M.-C. Gobeil et al.   SCIENCE

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

(2021) Markus Hoffmann et al.   CELL

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

(2021) Jun Zhang et al.   SCIENCE

Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding

(2021) Dhiraj Mannar et al.   Cell Reports

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

(2021) Rafael Bayarri-Olmos et al.   eLife

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Site-specific glycan analysis of the SARS-CoV-2 spike

(2020) Yasunori Watanabe et al.   SCIENCE

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

(2020) Xiangyang Chi et al.   SCIENCE

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models

(2020) Wei Li et al.   CELL

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

(2020) M. Alejandra Tortorici et al.   SCIENCE

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

(2020) Carina Conceicao et al.   PLOS BIOLOGY

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

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Features and development ofCoot

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