Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors

Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease

(2014) Marja D. Sepers et al.   DRUG DISCOVERY TODAY

Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

(2014) D. Shilling et al.   JOURNAL OF NEUROSCIENCE

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Distinct roles of M1 and M3 muscarinic acetylcholine receptors controlling oscillatory and non-oscillatory [Ca2+]i increase

(2013) Kyoko Nakamura et al.   CELL CALCIUM

Type 1 Inositol Trisphosphate Receptor Regulates Cerebellar Circuits by Maintaining the Spine Morphology of Purkinje Cells in Adult Mice

(2013) T. Sugawara et al.   JOURNAL OF NEUROSCIENCE

50 years of allosteric interactions: the twists and turns of the models

(2013) Jean-Pierre Changeux   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A study of molecular changes relating to energy metabolism and cellular stress in people with Huntington’s disease: looking for biomarkers

(2012) Jolanta Krzysztoń-Russjan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Transglutaminase Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation

(2012) M. Basso et al.   JOURNAL OF NEUROSCIENCE

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

(2012) Min-Duk Seo et al.   NATURE

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Revisiting Channel Allostery: A Coherent Mechanism in IP3 and Ryanodine Receptors

(2012) K. Hamada et al.   Science Signaling

Monitoring of transglutaminase2 under different oxidative stress conditions

(2011) Daniela Caccamo et al.   AMINO ACIDS

Ins(1,4,5)P3receptor-mediated Ca2+signaling and autophagy induction are interrelated

(2011) Jean-Paul Decuypere et al.   Autophagy

Functional characterization of the P1059L mutation in the inositol 1,4,5-trisphosphate receptor type 1 identified in a Japanese SCA15 family

(2011) Haruka Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

(2011) Lise Munsie et al.   HUMAN MOLECULAR GENETICS

Behavioral and In Vivo Electrophysiological Evidence for Presymptomatic Alteration of Prefrontostriatal Processing in the Transgenic Rat Model for Huntington Disease

(2011) S. Hohn et al.   JOURNAL OF NEUROSCIENCE

Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor

(2011) Chun-Chi Lin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium

(2011) T. Shinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexible Architecture of IP3R1 by Cryo-EM

(2011) Steven J. Ludtke et al.   STRUCTURE

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Two Italian Families with ITPR1 Gene Deletion Presenting a Broader Phenotype of SCA15

(2010) Eleonora Di Gregorio et al.   CEREBELLUM

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

(2010) Stephen J. McConoughey et al.   EMBO Molecular Medicine

Calcium-dependent Conformational Changes in Inositol Trisphosphate Receptors

(2010) Georgia Anyatonwu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies of Inositol 1,4,5-Trisphosphate Receptor

(2010) Jenny Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor

(2010) Takayasu Higo et al.   NEURON

Neurocognitive signs in prodromal Huntington disease.

(2010) Julie C. Stout et al.   NEUROPSYCHOLOGY

Transglutaminase 2 is involved in autophagosome maturation

(2009) Manuela D'Eletto et al.   Autophagy

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Surface Accessibility and Conformational Changes in the N-terminal Domain of Type I Inositol Trisphosphate Receptors

(2009) Georgia Anyatonwu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-protein-coupled Receptor Kinase-interacting Proteins Inhibit Apoptosis by Inositol 1,4,5-Triphosphate Receptor-mediated Ca2+Signal Regulation

(2009) Songbai Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transglutaminases and neurodegeneration

(2009) Thomas M. Jeitner et al.   JOURNAL OF NEUROCHEMISTRY

Synthetic partial agonists reveal key steps in IP3 receptor activation

(2009) Ana M Rossi et al.   Nature Chemical Biology

Burst-Timing-Dependent Plasticity of NMDA Receptor-Mediated Transmission in Midbrain Dopamine Neurons

(2009) Mark T. Harnett et al.   NEURON

Transglutaminases and Disease: Lessons From Genetically Engineered Mouse Models and Inherited Disorders

(2009) Siiri E. Iismaa et al.   PHYSIOLOGICAL REVIEWS

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE

The propensity for deamidation and transamidation of peptides by transglutaminase 2 is dependent on substrate affinity and reaction conditions

(2008) Jorunn Stamnaes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Transglutaminases and Transglutaminase-Catalyzed Cross-Links Colocalize with the Pathological Lesions in Alzheimer's Disease Brain

(2008) Micha M.M. Wilhelmus et al.   BRAIN PATHOLOGY

Tissue transglutaminase: A novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases

(2008) Micha M.M. Wilhelmus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Substrate Preference of Transglutaminase 2 Revealed by Logistic Regression Analysis and Intrinsic Disorder Examination

(2008) Eva Csosz et al.   JOURNAL OF MOLECULAR BIOLOGY

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

(2008) Hua Zhang et al.   NEUROBIOLOGY OF DISEASE

Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families

(2008) K. Hara et al.   NEUROLOGY

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON