At the heart of computational modelling

Calcium Dynamics in the Ventricular Myocytes of SERCA2 Knockout Mice: A Modeling Study

(2011) L. Li et al.   BIOPHYSICAL JOURNAL

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype

(2011) S. G. Campbell et al.   Journal of the Royal Society Interface

Low-energy control of electrical turbulence in the heart

(2011) Stefan Luther et al.   NATURE

Patient-specific modeling of dyssynchronous heart failure: A case study

(2011) Jazmin Aguado-Sierra et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project

(2011) Chris Bradley et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Reversible Cardiac Conduction Block and Defibrillation with High-Frequency Electric Field

(2011) H. Tandri et al.   Science Translational Medicine

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

(2011) J. D. Moreno et al.   Science Translational Medicine

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform

(2010) L. Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Electromechanical wavebreak in a model of the human left ventricle

(2010) R. H. Keldermann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Models of cardiac electromechanics based on individual hearts imaging data

(2010) Viatcheslav Gurev et al.   Biomechanics and Modeling in Mechanobiology

Distribution of Electromechanical Delay in the Heart: Insights from a Three-Dimensional Electromechanical Model

(2010) V. Gurev et al.   BIOPHYSICAL JOURNAL

Length-dependent tension in the failing heart and the efficacy of cardiac resynchronization therapy

(2010) Steven A. Niederer et al.   CARDIOVASCULAR RESEARCH

Ventricular Dilation and Electrical Dyssynchrony Synergistically Increase Regional Mechanical Nonuniformity But Not Mechanical Dyssynchrony

(2010) Roy C.P. Kerckhoffs et al.   Circulation-Heart Failure

Mapping of cardiac electrical activation with electromechanical wave imaging: An in silico–in vivo reciprocity study

(2010) Jean Provost et al.   HEART RHYTHM

Phenomics: the next challenge

(2010) David Houle et al.   NATURE REVIEWS GENETICS

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

(2010) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

(2010) Amrita X. Sarkar et al.   PLoS Computational Biology

Mechanisms of Mechanically Induced Spontaneous Arrhythmias in Acute Regional Ischemia

(2009) Xiao Jie et al.   CIRCULATION RESEARCH

Chaste: A test-driven approach to software development for biological modelling

(2009) Joe Pitt-Francis et al.   COMPUTER PHYSICS COMMUNICATIONS

Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics

(2009) Stuart G. Campbell et al.   EXPERIMENTAL PHYSIOLOGY

A meta-analysis of cardiac electrophysiology computational models

(2009) S. A. Niederer et al.   EXPERIMENTAL PHYSIOLOGY

Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart

(2009) J. Lee et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Markov models for ion channels: versatility versus identifiability and speed

(2009) M. Fink et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential

(2009) J. R. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling multi-physics models to cardiac mechanics

(2009) D.A. Nordsletten et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Role of the Frank–Starling Law in the Transduction of Cellular Work to Whole Organ Pump Function: A Computational Modeling Analysis

(2009) Steven A. Niederer et al.   PLoS Computational Biology

Mathematical model of the neonatal mouse ventricular action potential

(2008) Linda J. Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Approximate Model of Cooperative Activation and Crossbridge Cycling in Cardiac Muscle Using Ordinary Differential Equations

(2008) John Jeremy Rice et al.   BIOPHYSICAL JOURNAL

Systems Approach to Understanding Electromechanical Activity in the Human Heart

(2008) Yoram Rudy et al.   CIRCULATION

Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model

(2008) S. G Campbell et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

CellML and associated tools and techniques

(2008) A. Garny et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

From Genotype to Phenotype: Systems Biology Meets Natural Variation

(2008) P. N. Benfey et al.   SCIENCE

In silico cancer modeling: is it ready for prime time?

(2008) Thomas S Deisboeck et al.   Nature clinical practice. Oncology

An improved numerical method for strong coupling of excitation and contraction models in the heart

(2007) Steven A. Niederer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY