Article
Cell & Tissue Engineering
Weiwei Xue, Caixia Fan, Bing Chen, Yannan Zhao, Zhifeng Xiao, Jianwu Dai
Summary: Transplantation of neural stem cells shows promise for restoring communication in spinal cord injury, but the inhibitory microenvironment often leads to glial differentiation rather than neuronal differentiation. Functional biomaterials can mitigate the adverse effects of the SCI microenvironment and promote neuronal differentiation of NSCs.
Article
Biochemistry & Molecular Biology
Ruolan Tan, Xiaoxuan Hu, Xinyi Wang, Meiqi Sun, Zhenlu Cai, Zixuan Zhang, Yali Fu, Xinlin Chen, Jing An, Haixia Lu
Summary: This study investigates the role of leptin in the biological properties of neural stem cells (NSCs). The findings suggest that leptin promotes the proliferation and neuronal differentiation of NSCs, potentially providing a promising approach for brain repair in neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qian Liu, Vsevolod Telezhkin, Wenkai Jiang, Yu Gu, Yan Wang, Wei Hong, Weiming Tian, Polina Yarova, Gaofeng Zhang, Simon Ming-yuen Lee, Peng Zhang, Min Zhao, Nicholas D. Allen, Emilio Hirsch, Josef Penninger, Bing Song
Summary: Neural stem cells have the potential for cell replacement therapy, but their tendency to differentiate into glial rather than neuronal phenotypes limits positive outcomes. Physiological electric field (EF) stimulation can boost the neuronal differentiation of neural stem cells without extra chemical side effects, providing a safe and efficient cell therapy for neurological recovery.
CELL AND BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Yifan Wang, Tengfei Zhao, Yiren Jiao, Hanxu Huang, Yongxiang Zhang, Ao Fang, Xuhua Wang, Yanling Zhou, Haochen Gu, Qionghua Wu, Jiang Chang, Fangcai Li, Kan Xu
Summary: This study investigates the effect of Laponite nanoplatelets on stem cell therapy. The results show that Laponite nanoplatelets can induce the neuronal differentiation of neural stem cells within five days in vitro, and the NF-kappa B pathway is involved in this process. Moreover, Laponite nanoplatelets can increase the survival rate of transplanted neural stem cells and promote their differentiation into mature neurons. The formation of connections between transplanted cells and host cells is confirmed by axon tracing. Therefore, Laponite nanoplatelets can be considered a convenient and practical biomaterial to enhance the efficacy of neural stem cell transplantation and promote repair of the injured spinal cord.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell & Tissue Engineering
Weiwei Xue, Haipeng Zhang, Yongheng Fan, Zhifeng Xiao, Yannan Zhao, Weiyuan Liu, Bai Xu, Yanyun Yin, Bing Chen, Jiayin Li, Yi Cui, Ya Shi, Jianwu Dai
Summary: The study showed that Epothilone D promoted the neuronal differentiation of NSCs and facilitated neuronal relay formation at the injury site. RNA sequencing revealed that Apol8 was upregulated during this process, indicating its role in promoting neuronal differentiation. Transplantation of Apol8-NSCs with LOCS improved motor function in mice with complete spinal cord transection, suggesting a promising therapeutic target for SCI repair.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Katarina Kiss Bimbova, Maria Bacova, Alexandra Kisucka, Jan Galik, Peter Zavacky, Nadezda Lukacova
Summary: Endurance training significantly upregulated the expression of growth factors and their receptors in low thoracic segments, and activated neuroplasticity and regeneration pathways in rats with spinal cord injury. Pre-training prior to SCI improved neurological scores and overall activity levels in rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Akihiro Ishii, Miki Furusho, Rashmi Bansal
Summary: Multiple intracellular signaling pathways, including Mek/ERK1/2-MAPK and PI3K/Akt/mTOR, are involved in regulating myelination in the peripheral nervous system. The roles of these pathways may differ during development and adulthood, highlighting the complexity of their interactions in Schwann cells.
Review
Biochemistry & Molecular Biology
Chih-Wei Zeng
Summary: The human nervous system has limited regenerative capabilities, while zebrafish exhibit remarkable regenerative abilities, making them an ideal model for studying inflammatory processes after injury. Such research has significant translational potential to enhance our understanding of recovery from damage and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Matthew Wind, Antigoni Gogolou, Ichcha Manipur, Ilaria Granata, Larissa Butler, Peter W. Andrews, Ivana Barbaric, Ke Ning, Mario R. Guarracino, Marysia Placzek, Anestis Tsakiridis
Summary: This study identified the signals guiding the transition of human NMP-like cells towards thoracic ventral spinal cord neurectoderm and defined an optimized protocol for generating thoracic MNs, facilitating the comparison of hPSC-derived spinal cord cells of distinct axial identities.
Article
Biochemistry & Molecular Biology
Diane Pelzer, Lauren S. Phipps, Raphael Thuret, Carlos J. Gallardo-Dodd, Syed Murtuza Baker, Karel Dorey
Summary: This study identified several genes specifically expressed in the spinal cord during regeneration, highlighting the importance of Foxm1 in spinal cord regeneration. Foxm1 was found to regulate the fate of neural progenitors post-division, rather than controlling their cell cycle length. The reduction in neurons in the regenerating spinal cord of foxm1(-/-) tadpoles suggests that neuronal differentiation plays a crucial role in the regenerative process.
Article
Clinical Neurology
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu
Summary: This study investigated the role of methyltransferase METTL3 in spinal cord injury (SCI). The expression of METTL3 and overall m6A modification level were significantly increased in neurons. Inhibition of METTL3 activity or expression can inhibit neuronal apoptosis after SCI through the m6A/Bcl-2 signaling pathway.
Article
Nutrition & Dietetics
Hye-Yeon Jang, Jeong-Mi Kim, Jong-Suk Kim, Byeong-Soo Kim, Young-Rae Lee, Jun Sang Bae
Summary: PBE inhibits osteoclast differentiation in BMMs by suppressing the RANKL-induced activated JNK/NF-κB/PLCγ2 signaling pathway and the expression of NFATc1 and c-Fos. PBE could be a potential therapeutic strategy or functional product for osteoclast-related bone disease.
Article
Chemistry, Multidisciplinary
Lior Wertheim, Reuven Edri, Yona Goldshmit, Tomer Kagan, Nadav Noor, Angela Ruban, Assaf Shapira, Irit Gat-Viks, Yaniv Assaf, Tal Dvir
Summary: Functional human neuronal network is engineered by mimicking embryonic development of the spinal cord in a 3D dynamic biomaterial-based microenvironment, showing therapeutic potential for regenerating injured spinal cord.
Article
Immunology
Fan Zhang, Fang Hong, Lu Wang, Renjie Fu, Jin Qi, Boyang Yu
Summary: This study elucidated the mechanism of how MrgprX2 regulates intracellular calcium levels in mast cell degranulation through the PI3K/AKT and PLCγ pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhiyuan Wang, Shuaijun Jia, Hailiang Xu, Xiaohui Wang, Botao Lu, Weidong Wu, Dageng Huang, Lingbo Kong, Xin Kang, Fang Tian, Lei Zhu, Dingjun Hao
Summary: In this study, the researchers developed a novel method to enhance the differentiation of spermatogonial stem cells (SSCs) into neurons. They coated aligned fibers with a self-assembled peptide, which improved the efficiency of SSC neuronal differentiation. The induced neurons derived from SSCs were able to form new relay circuits, myelinate, and establish synapses when implanted into spinal cord injury lesion sites. These SSC-derived neurons were able to survive and function in the spinal cord injury microenvironment, promoting locomotion recovery.
Article
Anesthesiology
Esperanza Recio-Pinto, Jose V. Montoya-Gacharna, Fang Xu, Thomas J. J. Blanck
ANESTHESIA AND ANALGESIA
(2016)
Article
Anesthesiology
Lola Franco, Thomas J. J. Blanck, Kimberly Dugan, Richard Kline, Geetha Shanmugam, Angela Galotti, Annelise von Bergen Granell, Michael Wajda
JOURNAL OF CLINICAL ANESTHESIA
(2016)
Article
Neurosciences
Alexandra Sideris, Boris Piskoun, Lori Russo, Monica Norcini, Thomas Blanck, Esperanza Recio-Pinto
Article
Geriatrics & Gerontology
Bernd R. Stab, Laura Martinez, Adriana Grismaldo, Alejandra Lerma, Maria L. Gutierrez, Luis A. Barrera, Jhon J. Sutachan, Sonia L. Albarracin
FRONTIERS IN AGING NEUROSCIENCE
(2016)
Article
Food Science & Technology
Sergio Lopez, Mitchell Marta, Luis Gonzalo Sequeda, Crispin Celis, Jhon Jairo Sutachan, Sonia Luz Albarracin
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Article
Neurosciences
Joseph Cichon, Thomas J. J. Blanck, Wen-Biao Gan, Guang Yang
NATURE NEUROSCIENCE
(2017)
Article
Neurosciences
Monica Norcin, Daniel Choi, Helen Lu, Mercedes Cano, Boris Piskoun, Alicia Hurtad, Alexandra Sideris, Thomas J. J. Blanck, Esperanza Recio-Pinto
Review
Neurosciences
Lady C. Mayorquin, Andrea V. Rodriguez, Jhon-Jairo Sutachan, Sonia L. Albarracin
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Anesthesiology
Lisa V. Doan, Olga Eydlin, Boris Piskoun, Richard P. Kline, Esperanza Recio-Pinto, Andrew D. Rosenberg, Thomas J. J. Blanck, Fang Xu
Article
Anesthesiology
Benjamin Drenger, Thomas J. J. Blanck, Boris Piskoun, E. Jaffrey, Esperanza Recio-Pinto, Alexandra Sideris
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2019)
Article
Neurosciences
C. Castillo, M. Norcini, L. A. Martin Hernandez, G. Correa, T. J. J. Blanck, E. Recio-Pinto
Article
Neurosciences
Monica Norcini, Alexandra Sideris, Lourdes A. Martin Hernandez, Jin Zhang, Thomas J. J. Blanck, Esperanza Recio-Pinto
FRONTIERS IN NEUROSCIENCE
(2014)
Meeting Abstract
Endocrinology & Metabolism
Sonia Luz Albarracin, Jose Maria Velasco, Coralia Osorio, Jhon-Jairo Sutachan
ANNALS OF NUTRITION AND METABOLISM
(2017)