Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

(2015) Walter Krause Neto et al.   AGE

Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise

(2015) Syed S. I. Bukhari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy

(2015) Vandre C. Figueiredo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling

(2015) Matthew S. Brook et al.   FASEB JOURNAL

Regulation of rDNA transcription in response to growth factors, nutrients and energy

(2015) Eric P. Kusnadi et al.   GENE

Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis

(2015) Tyler J. Kirby et al.   JOURNAL OF APPLIED PHYSIOLOGY

The effects of age and resistance loading on skeletal muscle ribosome biogenesis

(2015) Michael J. Stec et al.   JOURNAL OF APPLIED PHYSIOLOGY

Commentaries on Viewpoint: What is the relationship between acute measure of muscle protein synthesis and changes in muscle mass?

(2015)   JOURNAL OF APPLIED PHYSIOLOGY

Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle

(2015) Daniel W. D. West et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protein supplementation does not alter intramuscular anabolic signaling or endocrine response after resistance exercise in trained men

(2015) Adam M. Gonzalez et al.   NUTRITION RESEARCH

Muscle Quality in Aging: a Multi-Dimensional Approach to Muscle Functioning with Applications for Treatment

(2015) Maren S. Fragala et al.   SPORTS MEDICINE

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

(2015) H. Robert Bergen et al.   Skeletal Muscle

Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion

(2015) Benjamin Toby Wall et al.   PLoS One

Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle

(2014) M. V. Franchi et al.   Acta Physiologica

A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans

(2014) Daniel J. Wilkinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle quality index improves with resistance exercise training in older adults

(2014) Maren S. Fragala et al.   EXPERIMENTAL GERONTOLOGY

Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy

(2014) G. A. Nader et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protein Ingestion to Stimulate Myofibrillar Protein Synthesis Requires Greater Relative Protein Intakes in Healthy Older Versus Younger Men

(2014) D. R. Moore et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men

(2014) Cameron J. Mitchell et al.   PLoS One

Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise

(2014) Renae J. Stefanetti et al.   Frontiers in Physiology

Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway

(2013) Hannah Crossland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle

(2013) Riki Ogasawara et al.   JOURNAL OF APPLIED PHYSIOLOGY

Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training

(2013) A. J. Murton et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of Testosterone and Progressive Resistance Exercise in Healthy, Highly Functioning Older Men With Low-Normal Testosterone Levels

(2013) Kerry L. Hildreth et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly

(2013) Leigh Breen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanical Muscle Function and Lean Body Mass During Supervised Strength Training and Testosterone Therapy in Aging Men with Low-Normal Testosterone Levels

(2013) Thue Kvorning et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Assessing the "Physical Cliff": Detailed Quantification of Age-Related Differences in Daily Patterns of Physical Activity

(2013) J. A. Schrack et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Muscle architecture and strength: Adaptations to short-term resistance training in older adults

(2013) Tyler C. Scanlon et al.   MUSCLE & NERVE

Resistance training induced increase in muscle fiber size in young and older men

(2012) A. A. Mero et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Undernutrition in older adults

(2012) J. E. Morley   FAMILY PRACTICE

Muscle protein synthesis in response to nutrition and exercise

(2012) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle Protein Synthetic Responses to Exercise: Effects of Age, Volume, and Intensity

(2012) V. Kumar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older Adults

(2012) C. S. Fry et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review

(2012) W. Kyle Mitchell et al.   Frontiers in Physiology

Aging with multimorbidity: A systematic review of the literature

(2011) Alessandra Marengoni et al.   AGEING RESEARCH REVIEWS

Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and women

(2011) Gordon I. Smith et al.   CLINICAL SCIENCE

Blunting of adaptive responses to resistance exercise training in women over 75y

(2011) C.A. Greig et al.   EXPERIMENTAL GERONTOLOGY

Long-term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by protein supplementation

(2011) Matthew M. Robinson et al.   FASEB JOURNAL

Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise

(2011) Bethan Phillips et al.   JOURNAL OF APPLIED PHYSIOLOGY

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Resistance exercise for muscular strength in older adults: A meta-analysis

(2010) Mark D. Peterson et al.   AGEING RESEARCH REVIEWS

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

(2010) Philip J Atherton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity

(2010) Rikke Krogh-Madsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Coomassie Staining as Loading Control in Western Blot Analysis

(2010) Charlotte Welinder et al.   JOURNAL OF PROTEOME RESEARCH

Influence of Resistance Exercise on Lean Body Mass in Aging Adults

(2010) MARK D. PETERSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Frailty and health related quality of life in older Mexican Americans

(2009) Meredith C Masel et al.   Health and Quality of Life Outcomes

Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans

(2009) David L. Mayhew et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human muscle protein synthesis and breakdown during and after exercise

(2009) Vinod Kumar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men

(2009) Fred R. Sattler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells

(2009) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

(2009) Micah J. Drummond et al.   JOURNAL OF PHYSIOLOGY-LONDON

Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise

(2009) Daniel R. Moore et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Physical Activity in the United States Measured by Accelerometer

(2009) RICHARD P. TROIANO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men

(2008) Lex B Verdijk et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic Responses to Reduced Daily Steps in Healthy Nonexercising Men

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

(2008) Vinod Kumar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols