Article
Multidisciplinary Sciences
Iman Ramazani Sarbandi, Ali Lesani, Mahdi Moghimi Zand, Reza Nosrati
Summary: The study introduces a biomimicry microfluidic method inspired by the anatomy of the female reproductive tract to separate motile sperm with a 100% separation efficiency.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Sandhya Sharma, Md Alamgir Kabir, Waseem Asghar
Summary: This study develops a microfluidic chip that isolates healthy sperm cells by taking advantage of their natural rheotaxis behavior. The chip consists of chambers and microchannels that separate motile sperm cells from unprocessed semen samples using fluid flow. The results show high motility and low sperm DNA fragmentation.
Article
Biochemical Research Methods
Yameng Liu, Miaomiao Wang, Ruojin Liu, Feng Qiu
Summary: This study aims to develop a simple and fast method for testing the phagocytic activity of unlabeled and native cells using high-resolution direct current insulator-based dielectrophoresis (DC-iDEP). The method reduces the time and cost of bacterial culture and fluorescent labeling, and the introduction of microfluidics reduces sample volume and reagent needed. The analysis of the biophysical property distributions of cells may lead to a cheaper and faster tool for evaluating medicinal effects. Furthermore, the study investigates the effect of berberine on reducing macrophage phagocytic activity for comparison.
Article
Biochemical Research Methods
Yimo Yan, Boxuan Zhang, Qiqi Fu, Jian Wu, Ran Liu
Summary: In recent years, humans have faced increasing challenges in reproduction, and assisted reproductive technology has played a key role in addressing these issues. Current sperm screening methods are inadequate, and research has shown that sperm exhibit chemotactic and thermotactic behavior. Researchers have developed an integrated system to screen sperm for these characteristics.
Article
Multidisciplinary Sciences
Shayan Valijam, Daniel P. G. Nilsson, Dmitry Malyshev, Rasmus Öberg, Alireza Salehi, Magnus Andersson
Summary: Dielectrophoresis is a technique that uses an electric field to manipulate neutral particles in a fluid. This paper presents the design, fabrication, and testing of a low-voltage dielectrophoretic device using 3D printing. The device, which fits on a microscope glass slide, incorporates microfluidic channels for particle separation. The authors demonstrate the separation efficiency of the device by introducing a mixture of polystyrene particles and tracking their progression under specific electric field conditions.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Afrouz Ataei, A. W. C. Lau, Waseem Asghar
Summary: The study introduces an effective sperm sorting microfluidic device that utilizes rheotaxis of sperm to select higher quality sperm under different flow conditions. Additionally, the device features a novel passively driven pumping system that requires no external power source. Sperm selected with this device at specific flow rates exhibit better motility, morphology, and DNA integrity compared to a control group.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Reproductive Biology
Rebecca Herbicht, Gregor Neufeld, Claudia Klein, Heiko Henning
Summary: The VetCountTM Harvester was compared to the BoviPureTM gradient centrifugation for purifying sperm in bovine IVF. Both methods significantly increased the proportion of motile sperm compared to untreated semen. The VetCountTM Harvester selected viable acrosome intact sperm cells with lower [Ca2+]i compared to BoviPureTM treated sperm. The fertilizing ability of the spermatozoa varied, with VetCountTM Harvester showing higher fertility in some cases.
Article
Chemistry, Analytical
Korakot Boonyaphon, Zhenglin Li, Sung-Jin Kim
Summary: In this study, a microfluidic recirculation system driven by water-head pressures was developed, which enables media recirculation in parallel channels with pulsatile and constant flows. The system allows control of flow rates and shear stress, and can be used for systematic and parallel analysis of cell response to fluidic shearing patterns.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Zhenao Gu, Xiaoqiang An, Ruiping Liu, Lunqiao Xiong, Junwang Tang, Chengzhi Hu, Huijuan Liu, Jiuhui Qu
Summary: The study demonstrates a microfluidic photoelectrochemical architecture with enhanced efficiency and selectivity for solar-chemical synthesis. The efficient charge separation leads to a 3-fold enhancement in product yield and a typical reaction selectivity of 85%, which is significantly higher than conventional methods. Integration of the microfluidic photoanode with an oxygen reduction cathode results in a self-sustained photocatalytic fuel cell with remarkably high open circuit voltage and short-circuit current.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Endocrinology & Metabolism
Yinlam Li, Li Jin, Yanquan Li, Jianing Qian, Zhengquan Wang, Xiaoguo Zheng, Chong Xie, Xuelian Zhang, Hefeng Huang, Yuchuan Zhou
Summary: This study reveals the involvement of LPA in regulating human sperm motility by enhancing glycolysis and activating L-type calcium channels. The findings shed new light on the understanding of the causes of asthenozoospermia and suggest that LPA could be used as a novel therapeutic agent to improve sperm function and fertilizing capacity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Analytical
Zhen Yang, Miaoning Ren, Ya Li, Mingxing Zhou, Jingyi Peng, Si Lin, Kang Du, Xian Huang
Summary: Methods to manipulate magnetic beads play a crucial role in determining the efficiency and size of in vitro diagnostic systems. This study proposes a technique to construct a fully integrated microfluidic device that enables automatic magnetic bead manipulation, rapid chemical reactions, and cleaning in a compact dimension similar to a USB disk. The device combines the precision control of multiple electromagnetic coils and the compactness of microfluidic channels, making it one of the smallest automatic magnetic bead manipulation systems.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Chuang Wang, Yusheng Fu, Jiuchuan Guo, Jinhong Guo
Summary: This article introduces a new clinical biochemical detection system based on a centrifugal microfluidic chip for rapid detection of renal function indices. The system is portable, easy to operate, and exhibits good stability and accuracy, showing great potential for future point-of-care testing.
Article
Genetics & Heredity
Cheng-Teng Hsu, Chun-I. Lee, Fong-Sian Lin, Fang-Zong Wang, Hui-Chen Chang, Tse-En Wang, Chun-Chia Huang, Hui-Mei Tsao, Maw-Sheng Lee, Ashok Agarwal
Summary: A live motile sperm sorting device (LensHooke (R) CA0) was compared with conventional density-gradient centrifugation (DGC) and microfluidic-based device (Zymot) in sperm selection. The results showed that CA0 yielded spermatozoa with better quality and lower DNA fragmentation index and acrosome reacted sperm rate compared to the other two methods.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Minjun Chen, Ruqaiya Aluunmani, Guido Bolognesi, Goran T. Vladisavljevic
Summary: Poly(ethylene glycol) diacrylate (PEGDA) microgels with tuneable size and porosity have various applications. The microgels were produced using modular droplet microfluidics and their properties were studied.
Article
Chemistry, Multidisciplinary
Amit Prabhakar, Ankur Jaiswar, Neha Mishra, Praveen Kumar, Amar Dhwaj, Prashant Nayak, Deepti Verma
Summary: This paper presents a novel microfluidic device for water purification, which can separate suspended impurities in water using multiple hydrodynamic effects to improve water purification efficiency. It shows potential in addressing the need for clean drinking water.
Article
Thermodynamics
Sasan Azarmanesh, Mohammad Zabetian Targhi
Summary: Using laser ignition can reduce combustion duration, improve thermal efficiency and pressure, decrease specific fuel consumption, solving challenges that spark plug cannot address.
Article
Thermodynamics
Yousef Alihosseini, Mohammad Zabetian Targhi, Mohammad Mahdi Heyhat
Summary: A combination of wavy and oblique grooved microchannel patterns was investigated to improve the performance of microchannel heat sinks. Type-2 showed the best heat transfer performance and pressure drop behavior, with an eta value close to 2.5.
APPLIED THERMAL ENGINEERING
(2021)
Article
Mechanics
Mostafa Soroor, Mohammad Zabetian Targhi, Seyed Ali Tabatabaei
Summary: In this study, a flow focusing droplet generator was designed using numerical simulation, and the numerical method was verified according to previous research. The study found that the deviation of simulations from experiments was small, which is helpful in choosing the optimal flow regime to increase droplet generation frequency and monodispersity.
EUROPEAN JOURNAL OF MECHANICS B-FLUIDS
(2021)
Article
Engineering, Biomedical
Seyed Ali Tabatabaei, Mohammad Zabetian Targhi
Summary: The study focuses on the application of microparticle and biological cell separation techniques on microfluidic chips, with an experimental analysis of the effectiveness of a novel inertial microfluidic system in separating biological particles. Results showed an acceptable efficiency of 86% for both monodisperse and polydisperse particles, demonstrating potential for integration into a broader point-of-care diagnostic system for blood samples.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yousef Alihosseini, Mohammad Reza Azaddel, Sahel Moslemi, Mehdi Mohammadi, Ali Pormohammad, Mohammad Zabetian Targhi, Mohammad Mahdi Heyhat
Summary: Research shows that the circular cross-section is the most efficient shape for the microchannel heat sink, with a 25% increase in heat transfer compared to the square shape at Reynolds number of 1150. Additionally, placing the circular cross-section microchannel below the PCR device can cool saliva samples in 16.5 seconds, saving 157.5 seconds for the whole amplification procedure compared to conventional air fans. Another advantage of using the microchannel heat sink is its small space requirements compared to other common cooling methods.
SCIENTIFIC REPORTS
(2021)
Article
Thermodynamics
Ziaulhaq Ahmadi, Mohammad Zabetian Targhi
Summary: This study investigated a premixed surface flame burner using chemiluminescence and image analysis. The flame temperature variations were found to be influenced by OH* emission and peaked in the lean range. Image analysis helped determine the stable flame range, while pollutant concentrations remained low under specific equivalence ratios.
Review
Engineering, Electrical & Electronic
Seyed Ali Tabatabaei, Mohammad Zabetian Targhi, Javane Javaherchian, Marzieh Yaghoubi
Summary: Microfluidics separation has gained attention for its advantages in biological and medical studies. Spiral microchannels, as a passive separation method, show promising benefits for separating circulating tumor cells. However, a comprehensive understanding of the principles and forces in these complex channels is still necessary.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Thermodynamics
Hossein Soltanian, Mohammad Zabetian Targhi, Mehdi Maerefat
Summary: This study examines the use of natural gas fired porous burners in heating appliances and analyzes the heat transfer behavior of a pot heated by a porous burner. The study evaluates the convection heat transfers on the side and bottom of the pot to assess the overall thermal performance of the burner, and presents an appropriate design for the burner-pot system.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Thermodynamics
Ali Fatemi, Ghassem Heidarinejad, Mohammad Zabetian Targhi, Mohammad Safarzadeh
Summary: This paper presents a new configuration of heating and cooling systems for a net zero energy building, which combines direct evaporating cooling with ground-coupling to reduce energy consumption. Through simulation in ten cities in Iran, it is confirmed that this system is suitable for a wide variety of climates and can reduce lifecycle costs compared to conventional systems.
ENERGY CONVERSION AND MANAGEMENT
(2023)
Article
Thermodynamics
Mostafa Fathi, Mohammad Mahdi Heyhat, Mohammad Zabetian Targhi, Sajjad Bigham
Summary: Porous-fin microchannel heat sinks have the potential to improve the thermal and hydraulic performances of microelectronic cooling systems. However, the reduced effective thermal conductivity of porous fins compared to solid fins can negatively impact the thermal performance of the microchannel heat sinks. This research confirms that replacing solid with porous fins can simultaneously enhance the thermal and hydraulic performances of microchannel heat sinks.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Thermodynamics
Ahmad Reza Roozbehi, Mohammad Zabetian Targhi, Mohammad Mahdi Heyhat, Ala Khatibi
Summary: This numerical study investigates the modification of the hexagonal pin fin geometry to enhance the thermal and hydraulic performance of a heat sink. The results show that a vertex angle of 60 degrees and a relative length of 1 yield the optimum performance of the heat sink.
INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW
(2023)
Article
Thermodynamics
Amir Rezazad Bari, Mohammad Zabetian Targhi, Mohammad Mahdi Heyhat
Summary: This study investigated the effect of hybrid pin-fin patterns on a heat sink's performance and studied flow characteristics such as secondary flow formation and flow-wall interaction. The findings showed that hybrid arrangements perform better than single pin-fin patterns. Case 3, in particular, exhibited the highest performance evaluation criteria with a value of 1.84 at Re = 900. The study also revealed that the instantaneous change in pattern from elliptical to hexagonal increased secondary flow and maximum velocity in the channel's cross-section.
INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW
(2023)
Article
Thermodynamics
Mostafa Fathi, Mohammad Mahdi Heyhat, Mohammad Zabetian Targhi, Sajjad Bigham
Summary: The thermal performance of microchannel heat sinks can be improved by using extended surfaces, but this negatively affects the hydraulic performance. Divergent microchannels offer higher hydraulic performances but lower thermal performances compared to parallel microchannels. This study examines the opposing effects of bifurcation and divergence on the thermo-hydraulic performance of bifurcated divergent microchannels.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Article
Biochemical Research Methods
Soroush Zeaei, Mohammad Zabetian Targhi, Iman Halvaei, Reza Nosrati
Summary: Researchers have developed a microfluidic chip that can separate highly motile sperm using their inherent rheotaxis and boundary-following behavior. The device can effectively separate over 16,000 motile sperm in under 20 minutes, while also assessing DNA integrity. This technology shows promising potential for clinical applications in assisted reproduction.