Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yanfei Hong, Zhulang Chu, Jingwei Kong, Qiuyi Li, Na Li, Liting Liu, Tong Wu, Jiajing Liu, Dongyu Ge, Jie Li, Guiying Peng
Summary: Recent studies have revealed that IL-17A plays a detrimental role in exacerbating intestinal immune injury caused by asthma, by facilitating neutrophil trafficking. These findings provide insights into exploring new potential biomarkers for treating asthma.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Alexander O. O. Mann, Bola S. S. Hanna, Andres R. Munoz-Rojas, Inga Sandrock, Immo Prinz, Christophe Benoist, Diane Mathis
Summary: The accumulation and function of γδT cells during skeletal muscle regeneration after acute injury are microbiota-dependent, providing a new perspective for the treatment of muscle pathologies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Freeha Khalid, Kiyoshi Takagi, Ai Sato, Mio Yamaguchi, Fouzia Guestini, Yasuhiro Miki, Minoru Miyashita, Hisashi Hirakawa, Yasuyo Ohi, Yoshiaki Rai, Yasuaki Sagara, Hironobu Sasano, Takashi Suzuki
Summary: This study found that IL-17A is significantly correlated with CXCL1 and CD66b in triple-negative breast cancer (TNBC), and IL-17A is also significantly associated with shorter disease-free and overall survival. In vitro experiments revealed that IL-17A induces neutrophil infiltration by upregulating CXCL1 mRNA expression, and this induction is significantly suppressed by an Akt inhibitor.
Article
Ophthalmology
Ananya Datta, Tiffany Truong, Ji Hyun Lee, Hart Horneman, Orneika Flandrin, Justin Lee, Naren G. Kumar, Rachel R. Caspi, David J. Evans, Suzanne M. J. Fleiszig
Summary: The study found that wearing contact lenses can cause corneal para-inflammation, which involves the presence of CD11c+ cells after 24 hours and Ly6G+ cells (neutrophils) after 5-6 days. The study also revealed the importance of IL-17 and gamma 8 T cells in the neutrophil response induced by contact lenses.
Article
Biochemistry & Molecular Biology
Zhaozhen Zhang, Xiaoran Ma, Zhuqing Zha, Zhiwei Zhao, Jitian Li
Summary: This study demonstrated that allopurinol effectively alleviated the IL-17A-induced inflammatory response in mast cells by suppressing the activated JNK/AP1 and NF-Kappa B pathways.
MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Judith Ju Ming Wong, Herng Lee Tan, Jieliang Zhou, Jan Hau Lee, Jing Yao Leong, Joo Guan Yeo, Yie Hou Lee
Summary: This study evaluated the respiratory cytokine profile in pediatric acute respiratory distress syndrome (PARDS) and identified different molecular signatures associated with severe and non-severe disease cases. Early severe PARDS cases showed up-regulated pro-inflammatory cytokines, while late PARDS cases had a differential lung cytokine signature with both up-regulated and down-regulated profiles separating severe and non-severe groups. This cytokine signature was associated with increased transcription, T cell activation, proliferation, and activation of the mitogen-activated protein kinase pathway underlying PARDS severity.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Johanna Seifert, Claudia Kuechler, Sebastian Drube
Summary: Mast cells (MCs) are sentinel cells that play an important role in the immune system's first line of defense. They sense the danger-associated molecular patterns (DAMPs) IL-33 and ATP, which are released upon cell damage, and respond to pathogens and allergens. The stem cell factor (SCF) maintains the functionality of MCs by regulating their cytokine production.
Article
Immunology
Charalampos Papagoras, Akrivi Chrysanthopoulou, Alexandros Mitsios, Maria Ntinopoulou, Victoria Tsironidou, Aristea K. Batsali, Helen A. Papadaki, Panagiotis Skendros, Konstantinos Ritis
Summary: The research found that neutrophil extracellular traps (NETs) formation was enhanced in patients with ankylosing spondylitis. NETs decorated with interleukin-17A (IL-17A) stimulated the differentiation of bone marrow mesenchymal stem cells (MSCs) towards bone-forming cells. The expression of IL-17A was regulated by IL-1 beta, and blocking the IL-1 beta signaling pathway disrupted osteogenesis driven by IL-17A-bearing NETs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Anthony Altieri, Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Breann Recksiedler, Victor Spicer, Pieter S. Hiemstra, Andrew J. Halayko, Neeloffer Mookherjee
Summary: This study identified proteins and signaling pathways altered by IL-17A/F and TNF-alpha exposure in the lungs, particularly impacting neutrophil migration. Functional validation and a murine model confirmed the importance of these proteins in inflammatory responses.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Surgery
Jia Wang, Lei Peng, Dan Chang, Da-qing Hong, Jiong Zhang
Summary: DCQD treatment improves SAP-induced pancreatic microcirculatory dysfunction by inhibiting neutrophil-mediated inflammation via inactivating HMGB1-TLR-4-IL-23-IL-17A signaling by targeting SIRT1, and also decreases HMGB1 acetylation, migration, and release in vitro.
Article
Rheumatology
Shinjiro Kaieda, Takashi Kinoshita, Asako Chiba, Sachiko Miyake, Tomoaki Hoshino
Summary: This study investigated the role of the IL-18 signalling pathway in autoantibody-induced arthritis using IL-18R alpha-deficient mice. The results showed that the IL-18/IL-18R alpha signalling pathway contributes to the development of autoantibody-induced arthritis by enhancing synovial tissue expression of IL-1 beta and inducing neutrophil recruitment and mast cell activation. Therefore, targeting the IL-18R alpha signalling pathway may be a potential therapeutic strategy for rheumatoid arthritis.
MODERN RHEUMATOLOGY
(2023)
Article
Immunology
Muneo Numasaki, Koyu Ito
Summary: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.
IRANIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Nathaniel L. Lartey, Salvador Valle-Reyes, Hilda Vargas-Robles, Karina E. Jimenez-Camacho, Idaira M. Guerrero-Fonseca, Ramon Castellanos-Martinez, Armando Montoya-Garcia, Julio Garcia-Cordero, Leticia Cedillo-Barron, Porfirio Nava, Jessica G. Filisola-Villasenor, Daniela Roa-Velazquez, Dan Zavala-Vargas, Edgar Morales-Rios, Citlaltepetl Salinas-Lara, Eduardo Vadillo, Michael Schnoor
Summary: Severe COVID-19 is characterized by lung injury, cytokine storm, and increased NLR. Inhibition of ADAM17/MMP significantly improves lung histology, prevents leukocyte infiltration, reduces proinflammatory cytokines, and lowers endothelial adhesion molecules, offering a promising treatment strategy for SARS-CoV-2-infected individuals.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liam Brierley, Federico Nanni, Jessica K. Polka, Gautam Dey, Mate Palfy, Nicholas Fraser, Jonathon Alexis Coates
Summary: During the COVID-19 pandemic, preprints in the biomedical sciences have gained significant attention. However, a study found that while some conclusions in preprints may change before publication, it does not significantly impact the overall findings.
Article
Cell Biology
Idaira M. Guerrero-Fonseca, Alexander Garcia-Ponce, Eduardo Vadillo, Nathaniel L. Lartey, Hilda Vargas-Robles, Sandra Chanez-Paredes, Ramon Castellanos-Martinez, Porfirio Nava, Abigail Betanzos, Brittany M. Neumann, Kinga Penkala-Auguste, Craig T. Lefort, Michael Schnoor
Summary: Neutrophil recruitment plays a critical role in sepsis, while excessive recruitment can lead to tissue damage. The actin-binding protein HS1 has been identified as a key regulator in neutrophil extravasation and its importance in sepsis has been demonstrated in a lethal sepsis model. HS1-deficient mice showed better survival, reduced lung damage and inflammation in sepsis. The absence of HS1 attenuated systemic neutrophil recruitment and altered expression of various molecules.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Faheem Shaik, Michaela, J. M. Balderstone, Samantha Arokiasamy, James R. Whiteford
Summary: The purpose of this review is to explore the biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Immunology
Nadia Moran-Garcia, Catalina Lopez-Saucedo, Adriana Becerra, Mario Meza-Segura, Felipe Hernandez-Cazares, Jair Guerrero-Baez, Silvia Galindo-Gomez, Victor Tsutsumi, Michael Schnoor, Alfonso Mendez-Tenorio, James P. Nataro, Teresa Estrada-Garcia
Summary: This study developed a novel mouse model of tEAEC infection that mimics human infection, revealing the pathogenic effects of EAEC 042 in the mouse ileum and causing dysbiosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Alexander Garcia-Ponce, Citlaltepetl Salinas-Lara, Klemens Rottner, Michael Schnoor
Summary: Cortactin plays a crucial role in regulating neutrophil trafficking and severity of sepsis-induced lung injury.
Article
Immunology
Nathaniel L. Lartey, Hilda Vargas-Robles, Idaira M. Guerrero-Fonseca, Porfirio Nava, Emmanuel K. Kumatia, Augustine Ocloo, Michael Schnoor
Summary: Inflammatory bowel diseases (IBD) are complex inflammatory disorders of the digestive tract, which cannot be cured. A drug named Annickia polycarpa extract (APE) may serve as an additional treatment strategy for IBD, alleviating symptoms and improving life quality.
IMMUNOLOGY LETTERS
(2022)
Article
Cell Biology
Ramon Castellanos-Martinez, Iliana I. Leon-Vega, Idaira M. Guerrero-Fonseca, Hilda Vargas-Robles, Karina E. Jimenez-Camacho, Gabriela Hernandez-Galicia, Vianney F. Ortiz-Navarrete, Klemens Rottner, Oscar Medina-Contreras, Michael Schnoor
Summary: This article investigates the role of cortactin in T cell activation and migration in T cell acute lymphoblastic leukemia (T-ALL), and its significance in T-ALL development. The study demonstrates that cortactin participates in immune synapse formation and migration in normal T cells, while its overexpression in leukemic T cells leads to organ infiltration. Therefore, cortactin could be a potential therapeutic target for T-ALL and other pathologies involving aberrant T cell responses.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)