Article
Multidisciplinary Sciences
Zhao Yang, C. Mary Schooling, Man Ki Kwok
Summary: The role of IL-1 family members/receptors in lung cancer remains uncertain, with no significant associations found in this study, although suggestive total effects were noted for certain IL-1 family members/receptors with lung cancer and its subtypes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nicolaas C. Budhiparama, Imelda Lumban-Gaol, Herawati Sudoyo, Rahadyan Magetsari, Tri Wibawa
Summary: This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. Three SNPs of IL-1R1, rs871659, rs3771202, and rs3917238, were associated with primary knee OA. No correlation was found between SNPs of IL-1R1 and IL-1RN and clinical or radiologic severity or serum concentrations of IL-1R1 and IL-1Ra. BMI and IL-1R1 rs3917238 genotype C/C were correlated with moderate-severe VAS scores.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Jiarui Mi, Zhengye Liu, Shengduo Pei, Xia Wu, Nan Zhao, Lingjuan Jiang, Zhenjie Zhang, Xiaoyin Bai
Summary: This study using Mendelian randomization found that IL-18 is causally associated with an increased risk of IBD, while IL-1Ra is inversely associated with the risk of IBD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: We developed a gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. Our findings demonstrate the potential of HSPC-mediated IL-1RA delivery as a therapeutic modality for suppressing tissue and organ inflammation in diverse immune-related diseases involving IL-1-driven inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: This study developed a lentivirus-mediated gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. The HSPC-mediated IL-1RA delivery showed therapeutic efficacy in various IL-1-driven inflammation models.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pediatrics
Roberta Caorsi, Antonella Insalaco, Francesca Bovis, Giorgia Martini, Marco Cattalini, Marcello Chinali, Alessandro Rimini, Chiara Longo, Silvia Federici, Camilla Celani, Giovanni Filocamo, Rita Consolini, Maria Cristina Maggio, Gloria Fadanelli, Francesco Licciardi, Micol Romano, Barbara Lia Teruzzi, Andrea Taddio, Angela Miniaci, Francesco La Torre, Alessandro De Fanti, Giulio Cavalli, Barbara Bigucci, Romina Gallizzi, Matteo Chinello, Massimo Imazio, Antonio Brucato, Rolando Cimaz, Fabrizio De Benedetti, Marco Gattorno
Summary: This study analyzed the treatment of pediatric patients with recurrent pericarditis using anti-IL-1 therapy. The study found that most patients received inadequate first-line treatment and only a few achieved drug-free remission. The effectiveness of anakinra was supported, but the different response rates to anakinra and canakinumab may suggest a role of IL-1 alpha in the pathogenesis of recurrent pericarditis.
JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Qin He, Mei Liu, Wenjie Huang, Xiaoping Chen, Bixiang Zhang, Tongyue Zhang, Yijun Wang, Danfei Liu, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia
Summary: SLC7A11 is involved in inflammation-induced HCC metastasis by promoting tumor-associated immune cell infiltration. Interrupting this oncogenic loop may offer a promising therapy strategy for inhibiting SLC7A11-mediated HCC metastasis.
Article
Multidisciplinary Sciences
Ryohei Nishida, Yuki Kawaguchi, Junpei Matsubayashi, Rie Ishikawa, Satoshi Kida, Kohtaro Takei
Summary: Research has shown that LOTUS plays a crucial role in synapse formation and memory function. Knockout mice exhibited decreased synaptic density and impaired memory formation, indicating the importance of LOTUS in these processes.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jinmei Zhang, Angela X. Wang, Yafei Wu, Shaoping Zhang
Summary: This study aimed to assess the role of interleukin - 1 receptor antagonist (IL-1RA) in a ligature-induced periodontal (LIP) model and investigate the mechanism of IL-1RA in regulating IL-17-mediated periodontal bone loss. The results showed that IL-1RA plays a protective role in the LIP model by suppressing the expansion of IL-17+ cells and preventing a hyper-IL-17 response in the gingiva.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Immunology
Yusha Wang, Jun Wang, Wenjie Zheng, Jiahui Zhang, Jinbo Wang, Taijie Jin, Panfeng Tao, Yibo Wang, Chenlu Liu, Jiqian Huang, Pui Y. Lee, Xiaomin Yu, Qing Zhou
Summary: A novel missense variant in IL-1R1 was identified in a patient with CRMO, leading to unopposed IL-1 signaling. Researchers designed an IL-1 therapeutic that effectively targets IL-1-driven diseases.
Review
Rheumatology
Lori Broderick, Hal M. Hoffman
Summary: This review summarizes the pathophysiological mechanisms of IL-1-mediated autoinflammation, describes the epidemiological and clinical features of autoinflammatory diseases, and discusses the challenges associated with diagnosis and treatment.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Istemi Serin, Yasemin Oyaci, Mustafa Pehlivan, Sacide Pehlivan
Summary: This study evaluated the effects of IL-1RN VNTR and IL-4 VNTR polymorphisms on MM for the first time, finding that IL-1RN VNTR gene variants were significantly higher in MM patients compared to healthy controls, and that PFS was significantly shorter in patients with IL-1RN VNTR non-2-allele carrier genotypes, but no significant effect on OS was observed.
Article
Immunology
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lelia Delamarre, Ira Mellman
Summary: Lipid-formulated RNA vaccines can cause systemic inflammatory responses in humans, which were not predicted in preclinical studies. The IL-1 pathway plays a key role in triggering vaccine-induced inflammation, but this effect is dampened in mice.
Article
Allergy
Justin A. Jarrell, Matthew C. Baker, Cory A. Perugino, Hang Liu, Michelle S. Bloom, Takashi Maehara, Heidi H. Wong, Tobias Lanz, Julia Z. Adamska, Sarah Kongpachith, Jeremy Sokolove, John H. Stone, Shiv S. Pillai, William H. Robinson
Summary: A subset of patients with IgG4-RD have autoantibodies against IL-1RA, which promote proinflammatory and profibrotic mediator production by neutralizing IL-1RA activity. These autoantibodies are also present in a subset of patients with SLE and RA, suggesting a potential common pathway in multiple autoimmune diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Daniela Cerezo-Wallis, Andres Hidalgo
Review
Immunology
Lidiane S. Torres, Andres Hidalgo
Summary: This review discusses the important role of neutrophils and their mechanisms in sickle cell disease (SCD), and highlights the use of SCD humanized mouse models and in vivo imaging techniques to study the dynamics of neutrophils in complex inflammatory environments and their contribution to vascular injury. The authors argue that neutrophils could be potential targets for the management of SCD complications.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Urology & Nephrology
Leticia Cuarental, Marta Ribagorda, Maria I. Ceballos, Aranzazu Pintor-Chocano, Sol M. Carriazo, Ana Dopazo, Enrique Vazquez, Beatriz Suarez-Alvarez, Pablo Cannata-Ortiz, Ana B. Sanz, Alberto Ortiz, Maria D. Sanchez-Nino
Summary: Increased expression of AP-1 transcription factor components, such as Fosl1, in tubular cells is an adaptive response in acute kidney injury (AKI). Proximal tubular Fosl1 expression preserves Klotho, limits the severity of tubular cell injury, and protects against AKI. Selective Fosl1 deficiency in proximal tubular cells worsens kidney inflammation, downregulates Klotho, and exacerbates AKI.
KIDNEY INTERNATIONAL
(2023)
Article
Oncology
Gloria Esteso, Maria Jose Felgueres, Alvaro F. Garcia-Jimenez, Christina Reyburn-Vales, Alberto Benguria, Enrique Vazquez, Hugh T. Reyburn, Nacho Aguilo, Carlos Martin, Eugenia Puentes, Ingrid Murillo, Esteban Rodriguez, Mar Vales-Gomez
Summary: In this study, it was found that stimulation with iBCG can expand oligoclonal gamma delta T-cells and anti-tumor NK cells in human peripheral blood mononuclear cells. These cells exhibited cytotoxicity and can inhibit the growth of bladder cancer. The expansion of these cells in vitro may provide a new approach for cell-based immunotherapy.
Article
Medicine, General & Internal
Andres Esteban-Cantos, Javier Rodriguez-Centeno, Juan C. Silla, Pilar Barruz, Fatima Sanchez-Cabo, Gabriel Saiz-Medrano, Julian Nevado, Beatriz Mena-Garay, Maria Jimenez-Gonzalez, Rosa de Miguel, Jose I. Bernardino, Roco Montejano, Julen Cadinanos, Cristina Marcelo, Lucia Gutierrez-Garcia, Patricia Martinez-Martin, Cedrick Wallet, Francois Raffi, Berta Rodes, Jose R. Arribas
Summary: This study investigates the effects of antiretroviral therapy (ART) on HIV-induced epigenetic modifications. It found that ART initiation modified DNA methylation levels at 845 CpG positions, with 49.3% of the changes being restored to the uninfected state. Untreated HIV infection was associated with DNA methylation changes in biological processes regulating the immune system and antiviral responses. Changes in DNA methylation levels after ART initiation were weakly correlated with changes in CD4+ cell counts and the CD4/CD8 ratio.
Article
Multidisciplinary Sciences
Ester Marina-Zarate, Ana Rodriguez-Ronchel, Manuel J. Gomez, Fatima Sanchez-Cabo, Almudena R. Ramiro
Summary: CTCF is a DNA-binding protein that plays important roles in chromatin structure organization and transcriptional regulation; however, the functional determinants of different CTCF-binding sites (CBS) are not well characterized. Using a conditional mouse model, we identified a set of CBSs that are lost upon CTCF depletion (lost CBSs) and another set that persists (retained CBSs). Retained CBSs are more similar to the consensus CTCF-binding sequence and usually span tandem CTCF peaks. Lost CBSs are enriched at enhancers and promoters and associated with active chromatin marks and higher transcriptional activity. In contrast, retained CBSs are enriched at TAD and loop boundaries, acting as chromatin barriers between distinct chromatin states.
Meeting Abstract
Biochemistry & Molecular Biology
Insa Klemt, Viktor Reshetnikov, Itziar Cossio Cuartero, Andres Hidalgo, Andriy Mokhir
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Stephan Culemann, Katharina Knab, Maximilien Euler, Anja Wegner, Hilal Garibagaoglu, Jochen Ackermann, Kim Fischer, Deborah Kienhoefer, Georgiana Crainiciuc, Jonas Hahn, Anika Grueneboom, Falk Nimmerjahn, Stefan Uderhardt, Andres Hidalgo, Georg H. Schett, Markus Hoffmann, Gerhard Kroenke
Summary: The authors have found that the anti-inflammatory effects of clodronate liposomes are not due to the depletion of mononuclear phagocytes, but rather a functional inhibition of polymorphonuclear neutrophils. This finding calls for a critical revision of the current literature on the role of monocytes and macrophages in inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Correction
Immunology
Stephan Culemann, Katharina Knab, Maximilien Euler, Anja Wegner, Hilal Garibagaoglu, Jochen Ackermann, Kim Fischer, Deborah Kienhoefer, Georgiana Crainiciuc, Jonas Hahn, Anika Grueneboom, Falk Nimmerjahn, Stefan Uderhardt, Andres Hidalgo, Georg Schett, Markus H. Hoffmann, Gerhard Kroenke
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Correction
Multidisciplinary Sciences
Alicia Villatoro, Vincent Cuminetti, Aurora Bernal, Carlos Torroja, Itziar Cossio, Alberto Benguria, Marc Ferre, Joanna Konieczny, Enrique Vazquez, Andrea Rubio, Peter Utnes, Almudena Tello, Xiaona You, Christopher G. Fenton, Ruth H. Paulssen, Jing Zhang, Fatima Sanchez-Cabo, Ana Dopazo, Anders Vik, Endre Anderssen, Andres Hidalgo, Lorena Arranz
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Samuel Ovadia, Alaz Ozcan, Andres Hidalgo
Summary: The biology and functions of neutrophils exhibit notable circadian patterns influenced by the circadian clock. The immune and inflammatory systems, among numerous physiological targets, are specifically influenced by these circadian oscillations. This review discusses the regulation of neutrophils, the wildcard of the immune system, by circadian mechanisms. It explores both intrinsic and extrinsic diurnal mechanisms governing the overall physiology and function of neutrophils, and speculates on unexplored relationships such as topology, metabolism, and tissue clock regulation, aiming to identify novel avenues for research in the field of circadian immunity.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
