An update on the current status and prospects of nitrosation pathways and possible root causes of nitrosamine formation in various pharmaceuticals

Risk assessment for nitrosated pharmaceuticals: A future perspective in drug development

(2022) Sebastian Schmidtsdorff et al.   ARCHIV DER PHARMAZIE

Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities

(2022) Krista L. Dobo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed

(2022) Yupeng Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan

(2022) Jinsheng Lin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study

(2022) Chun-Hsiang Wang et al.   International Journal of Environmental Research and Public Health

An Organic Chemist’s Guide to N-Nitrosamines: Their Structure, Reactivity, and Role as Contaminants

(2021) Jessica C. Beard et al.   JOURNAL OF ORGANIC CHEMISTRY

Critical Analysis of Drug Product Recalls due to Nitrosamine Impurities

(2021) Sonali S. Bharate   JOURNAL OF MEDICINAL CHEMISTRY

Investigating the root cause of N-nitrosodimethylamine formation in metformin pharmaceutical products

(2021) Nasr Eldin Hussein Nasr et al.   Expert Opinion On Drug Safety

Nitrosamine contamination in pharmaceuticals: threat, impact, and control

(2021) Bodin Tuesuwan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride

(2021) Hidetomo Yokoo et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Nitrosamine Reactivity: A Survey of Reactions and Purge Processes

(2021) Christopher J. Borths et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA)

(2021) Joel P. Bercu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Developing Structure-Activity Relationships for N-Nitrosamine Activity

(2021) Kevin P. Cross et al.   Computational Toxicology

The determination of two analogues of 4-(azidomethyl)-1,1'-biphenyl as potential genotoxic impurities in the active pharmaceutical ingredient of several sartans containing a tetrazole group

(2021) Jakub Jireš et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The EU Response to the Presence of Nitrosamine Impurities in Medicines

(2021) Robin Ruepp et al.   Frontiers in Medicine

Regulatory Updates and Analytical Methodologies for Nitrosamine Impurities Detection in Sartans, Ranitidine, Nizatidine, and Metformin along with Sample Preparation Techniques

(2020) Khaja Moinuddin Shaik et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

Pathways for N-nitroso compound formation: secondary amines and beyond

(2020) Rocio López-Rodríguez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Are all nitrosamines concerning? A review of mutagenicity and carcinogenicity data

(2020) Andrew Thresher et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Temperature-Dependent Formation of N-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets

(2020) Yasuhiro Abe et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The Association between Ranitidine Use and Gastrointestinal Cancers

(2020) Gerald McGwin   Cancers

Short commentary on NDMA (N-nitrosodimethylamine) contamination of valsartan products

(2019) David J. Snodin et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hypertension Hot Potato — Anatomy of the Angiotensin-Receptor Blocker Recalls

(2019) J. Brian Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estimation of nizatidine gastric nitrosatability and product toxicity via an integrated approach combining HILIC, in silico toxicology, and molecular docking

(2019) Rania El-Shaheny et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Characterization of N-nitrosodimethylamine formation from the ozonation of ranitidine

(2017) Juan Lv et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

tert-Butyl Nitrite-Mediated Synthesis of N-Nitrosoamides, Carboxylic Acids, Benzocoumarins, and Isocoumarins from Amides

(2017) Subhash L. Yedage et al.   JOURNAL OF ORGANIC CHEMISTRY

Oral intake of ranitidine increases urinary excretion ofN-nitrosodimethylamine

(2016) Teng Zeng et al.   CARCINOGENESIS

Effect of oxidation on amine-based pharmaceutical degradation and N-Nitrosodimethylamine formation

(2015) Xiaofeng Wang et al.   WATER RESEARCH

NDMA Formation by Chloramination of Ranitidine: Kinetics and Mechanism

(2012) Julien Le Roux et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

An Efficient, Commercially Viable, and Safe Process for Preparation of Losartan Potassium, an Angiotensin II Receptor Antagonist

(2012) Suri Babu Madasu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

N-Nitrosation of Secondary Amines Usingp-TSA-NaNO2as a Novel Nitrosating Agent Under Mild Conditions

(2010) Sanjay P. Borikar et al.   SYNTHETIC COMMUNICATIONS

Advances in the application of N2O4/NO2 in organic reactions

(2010) Morteza Shiri et al.   TETRAHEDRON

Demonstration of 20 pharmaceuticals and personal care products (PPCPs) as nitrosamine precursors during chloramine disinfection

(2010) Ruqiao Shen et al.   WATER RESEARCH

Bismuth Chloride–Sodium Nitrite: A Novel Reagent for ChemoselectiveN-Nitrosation

(2009) Atul C. Chaskar et al.   SYNTHETIC COMMUNICATIONS

Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds☆Species: Rat; Sex: Male; Route of administration: Water

(2008) Aliuska Morales Helguera et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY