Article
Materials Science, Multidisciplinary
Nara S. Soares, Luciana M. Hollanda, Conceicao M. V. Elias, Marleane M. F. Azevedo, Francisco Eroni P. Santos, Anderson O. Lobo, Fernanda R. Marciano
Summary: This study reported the antibacterial effect of electrospun blends modified with quaternary amine group, which increased the positive charge and killed more bacteria.
Article
Biotechnology & Applied Microbiology
Michela Licciardello, Gianluca Ciardelli, Chiara Tonda-Turo
Summary: In this study, nanofibers based on a PCL-PANI blend were successfully fabricated using electrospinning technology. The resulting fibrous substrate showed good stability in physiological conditions. To improve the hydrophilicity of the surface, atmospheric plasma treatment was applied, resulting in a more favorable biological response. In vitro tests confirmed the viability and physiological-like morphology of cells cultured on the plasma treated PCL-PANI nanofibrous scaffolds.
BIOENGINEERING-BASEL
(2021)
Article
Polymer Science
Raul Rosales-Ibanez, Alejandro Emmanuel Viera-Ruiz, Juan Valerio Cauich-Rodriguez, Hugo Joel Carrillo-Escalante, Arely Gonzalez-Gonzalez, Jesus Jiovanni Rodriguez-Martinez, Fernando Hernandez-Sanchez
Summary: This work focuses on manufacturing a scaffold for tissue engineering of the bone system. The scaffold is shaped like a rabbit tibia and is obtained using a 3D-printer. The scaffold is then covered with a layer of synthesized polycaprolactone to improve cell adhesion. The scaffold is characterized using various methods to evaluate its biocompatibility and osteogenic differentiation capability.
Article
Biochemistry & Molecular Biology
Megane Beldjilali-Labro, Rachid Jellali, Alexander David Brown, Alejandro Garcia Garcia, Augustin Lerebours, Erwann Guenin, Fahmi Bedoui, Murielle Dufresne, Claire Stewart, Jean-Francois Grosset, Cecile Legallais
Summary: The goal of this study was to design and evaluate a multi-scale scaffold for promoting the differentiation of C2C12 skeletal myoblasts. The researchers found that the scaffold had tunable mechanical properties and improved the alignment and length of myotubes, leading to enhanced organization of reconstructed skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Sneh Gautam, Shiv Dutt Purohit, Hemant Singh, Amit Kumar Dinda, Pravin D. Potdar, Chhavi Sharma, Chia -Fu Chou, Narayan Chandra Mishra
Summary: Bone tissue engineering has received attention for the treatment of bone injury. A tri-polymer scaffold (PCL-gelatin-chitosan) was fabricated through electrospinning and treated with nanohydroxyapatite. The modified scaffold showed a uniform distribution of nanohydroxyapatite particles on the surface of fibers.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Pongphun Sukum, Winita Punyodom, Somsak Dangtip, Pipath Poramapijitwat, Donraporn Daranarong, Thannaphat Jenvoraphot, Mudtorlep Nisoa, Chakkrapong Kuensaen, Dheerawan Boonyawan
Summary: The wound healing process can be disrupted by various factors, with inflammation playing a crucial role. Wound dressings made with PVA, CS, PEG, and Mangifera extract can effectively reduce infection and inflammation, providing an environment for faster healing. The use of plasma treatment improves the electrospinning of polymer solutions, resulting in enhanced properties of the electrospun nanofiber membrane, including increased viscosity, conductivity, and fiber diameter. Incorporating mangiferin extract further enhances the antimicrobial properties of the membrane and accelerates wound healing.
Article
Biotechnology & Applied Microbiology
Sanaz Behtaj, Fereshteh Karamali, Elahe Masaeli, Yuri G. Anissimov, Maksym Rybachuk
Summary: This study investigates the impact of different polyester-based biopolymer materials blended with PCL on the attachment and proliferation of RPCs, revealing that PGS/PCL scaffolds promote RPC attachment and proliferation more favorably compared to other blends, showing potential for future clinical therapy for retinal degenerative disorders.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Polymer Science
Zahra Moazzami Goudarzi, Tayebeh Behzad, Laleh Ghasemi-Mobarakeh, Mahshid Kharaziha
Summary: The study demonstrated that the addition of ACNF significantly improved the tensile strength of PCL/Gel scaffold, while reducing the degradation rate. Incorporation of ACNF showed no cytotoxic effects and promoted cell proliferation.
Article
Biochemistry & Molecular Biology
Dana Rachmiel, Inbar Anconina, Safra Rudnick-Glick, Michal Halperin-Sternfeld, Lihi Adler-Abramovich, Amit Sitt
Summary: Bone tissue engineering involves regenerating lost bone using biomaterial scaffolds that mimic the extracellular matrix. A composite scaffold was successfully fabricated using electrospinning with polycaprolactone, hyaluronic acid, and a self-assembling peptide, promoting cell attachment and osteogenic differentiation. This multi-component approach shows potential for creating advanced scaffolds for bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jingjing Tian, Thomas E. Paterson, Jingjia Zhang, Yingxing Li, Han Ouyang, Ilida Ortega Asencio, Paul V. Hatton, Yu Zhao, Zhou Li
Summary: The infection of implanted biomaterial scaffolds is a challenging issue, and traditional treatment methods are becoming less practical. In this study, a novel PCL scaffold functionalized with ZnO nanowires was developed and characterized. The results showed that the ZnO nanowires were successfully incorporated into the scaffold, and it exhibited excellent antibacterial properties and biocompatibility, making it a promising choice for implanted scaffolds in tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mohammadalipour, Mehrdad Asadolahi, Zahra Mohammadalipour, Tayebeh Behzad, Saeed Karbasi
Summary: Polyhydroxybutyrate (PHB) nanofibers were prepared by electrospinning and their surface was modified by atmospheric plasma. The modified nanofibers showed lower water contact angle, appropriate degradation rate, and outstanding biomineralization compared to the untreated samples. Cell behavior analyses also demonstrated better cell proliferation with the modified mats in bone tissue engineering. These findings support the use of plasma surface modification as a quick, environmentally friendly, and low-cost approach to enhance the performance of nanofibers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Claudia Sanhueza, Jeyson Hermosilla, Catherine Klein, Alejandra Chaparro, Ivan Valdivia-Gandur, Victor Beltran, Francisca Acevedo
Summary: Peri-implantitis is a serious condition that can lead to dental implant failure. This study aimed to develop an electrospun scaffold loaded with cholecalciferol to treat peri-implantitis. The scaffold exhibited good mechanical properties and supported cell attachment and proliferation. The cholecalciferol-loaded scaffold promoted bone tissue regeneration. Further studies are needed to confirm the efficacy and safety of the scaffold.
Article
Multidisciplinary Sciences
Naeemeh Peidavosi, Mahmoud Azami, Nima Beheshtizadeh, Ahmad Ramazani Saadatabadi
Summary: Recent trends in tissue engineering technology have focused on utilizing bioactive scaffolds to generate electrical potentials that have appropriate effects on cell behaviors. This study aimed to develop a piezo-electrical stimuli scaffold with high electrical conductivity for bone and cartilage tissue regeneration. The scaffolds were prepared using Barium Titanate nanoparticles as a piezoelectric material and highly conductive Polyaniline nanoparticles as a dopant. The conductivity and piezoelectric properties of the scaffolds were evaluated, and it was found that the PCL/PANI5/BT40 composite exhibited unprecedented voltage and desirable properties for tissue engineering applications.
SCIENTIFIC REPORTS
(2022)
Article
Polymer Science
Mahsa Khalili, Hamid Keshvari, Rana Imani, Alireza Naderi Sohi, Elaheh Esmaeili, Maryam Tajabadi
Summary: Nanotechnology, particularly the synthesis of G3-SPIONs and magnetic PCL nanofibers, shows promise in bone tissue regeneration. The combination of osteogenic media and PEMF exposure on ADMSCs cultured on the magnetic scaffold enhances osteogenic differentiation. The study highlights the potential of utilizing magnetic scaffolds in tissue engineering applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Engineering, Civil
Sara Pedram, Hamid Reza Mortaheb, Faranzaneh Arefi-Khonsa
JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA
(2019)
Article
Chemistry, Multidisciplinary
Melike Gozutok, Veera Sadhu, Hilal Turkoglu Sasmazel
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2019)
Article
Materials Science, Coatings & Films
Abdessadk Anagri, Alibi Baitukha, Catherine Debiemme-Chouvy, Ivan T. Lucas, Jerome Pulpytel, T. T. Mai Tran, Seyedshayan Tabibian, Farzaneh Arefi-Khonsari
SURFACE & COATINGS TECHNOLOGY
(2019)
Article
Engineering, Biomedical
Aysenur Topsakal, Nazmi Ekren, Osman Kilic, Faik N. Oktar, Mahir Mahirogullari, Ozan Ozkan, Hilal Turkoglu Sasmazel, Mustafa Turk, Iuliana M. Bogdan, George E. Stan, Oguzhan Gunduz
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2020)
Article
Materials Science, Biomaterials
Alibi Baitukha, Iman Al-Dybiat, Azadeh Valinataj-Omran, Jerome Pulpytel, Marc Pocard, Massoud Mirshahi, Farzaneh Arefi-Khonsari
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Elif Ilhan, Sumeyye Cesur, Ece Guler, Fadime Topal, Deniz Albayrak, Mehmet Mucahit Guncu, Muhammet Emin Cam, Turgut Taskin, Hilal Turkoglu Sasmazel, Burak Aksu, Faik Nuzhet Oktar, Oguzhan Gunduz
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Pharmacology & Pharmacy
Muhammet Emin Cam, Ayse Nur Hazar-Yavuz, Sumeyye Cesur, Ozan Ozkan, Hussain Alenezi, Hilal Turkoglu Sasmazel, Mehmet Sayip Eroglu, Francis Brako, Jubair Ahmed, Levent Kabasakal, Guogang Ren, Oguzhan Gunduz, Mohan Edirisinghe
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Ozan Ozkan, Hilal Turkoglu Sasmazel, Erhan Biskin
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2020)
Article
Polymer Science
Sena Su, Tuba Bedir, Cevriye Kalkandelen, Ahmet Ozan Basar, Hilal Turkoglu Sasmazel, Cem Bulent Ustundag, Mustafa Sengor, Oguzhan Gunduz
Summary: New composite materials based on poly(epsilon-caprolactone)/polyethylene oxide loaded with hyaluronic acid (HA) and keratin (KR) were produced using emulsion and coaxial electrospinning methods. The fibers demonstrated distinct morphological and chemical characteristics, and showed potential for wound healing applications through in vitro studies, as the HA and KR incorporated into the fiber structure increased cell viability and proliferation synergistically.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Hilal Turkoglu Sasmazel, Marwa Alazzawi, Nabeel Kadim Abid Alsahib
Summary: Atmospheric plasma treatment is an effective surface treatment technique for enhancing the biocompatibility of polymers in biomedical applications, without changing their bulk properties. This treatment plays a crucial role in promoting cell adhesion, proliferation, and growth on polymer surfaces.
Review
Physics, Applied
Nilanjal Misra, Sudhir Bhatt, Farzaneh A. Khonsari, Virendra Kumar
Summary: Plasma processing has a wide range of biomedical applications, including the design of biosensors and antibiofouling surfaces. In the current COVID-19 situation, applying plasma processes can offer better antiviral solutions and reusable personal protective equipment, which are important for combating the pandemic and preventing future outbreaks.
PLASMA PROCESSES AND POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Marwa Alazzawi, Nabeel Kadim Abid Alsahib, Hilal Turkoglu Sasmazel
Summary: The study developed a core/shell nanofibrous membrane for guided bone regeneration, with a core of PVA:Gly and a shell of PCL, showing desirable nano-scale fiber diameter and microscale pore size, as well as ideal mechanical properties and wettability for bone regeneration applications.
Article
Engineering, Biomedical
Arnau Cuesta Puigmal, Musa Ayran, Songul Ulag, Eray Altan, Mehmet Mucahit Guncu, Burak Aksu, Barkan Kagan Durukan, Hilal Turkoglu Sasmazel, Roman A. Perez, Erhan Koc, Desmond O'Callaghan, Oguzhan Gunduz
Summary: This research focuses on the development and characterization of polyvinyl alcohol/chitosan nanofibers containing fucoidan. The results showed that the addition of fucoidan enhanced the antibacterial activity and biocompatibility of the nanofibers.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Ahmet Ozan Basar, Veera Sadhu, Hilal Turkoglu Sasmazel
BIOMEDICAL MATERIALS
(2019)
Article
Engineering, Environmental
Tao Peng, Jian Zhang, Srimanta Ray, Fatemeh Saadat Ghareh Bagh, Houssam Fakhouri, Farzaneh Arefi-Khonsari, Jerald A. Lalman
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2019)