Coenzyme Q biochemistry and biosynthesis

Mitochondria-targeted CoQ10 loaded PLGA-b-PEG-TPP nanoparticles: Their effects on mitochondrial functions of COQ8B HK-2 cells

(2022) Hamide Sena Ozbay et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Defining mitochondrial protein functions through deep multiomic profiling

(2022) Jarred W. Rensvold et al.   NATURE

Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel

(2022) Michael P. Murphy et al.   Nature Chemical Biology

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

(2022) Pranavi Koppula et al.   Nature Communications

Mechanisms and Therapeutic Effects of Benzoquinone Ring Analogs in Primary CoQ Deficiencies

(2022) Alba Pesini et al.   Antioxidants

2-Propylphenol Allosterically Modulates COQ8A to Enhance ATPase Activity

(2022) Nathan H. Murray et al.   ACS Chemical Biology

CYP7A1, NPC1L1, ABCB1, and CD36 Polymorphisms Associated with Coenzyme Q10 Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ10 Supplementation in Women

(2022) Michiyo Takahashi et al.   Nutrients

Chemistry of Lipoquinones: Properties, Synthesis, and Membrane Location of Ubiquinones, Plastoquinones, and Menaquinones

(2022) Margaret M. Braasch-Turi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The efficacy of coenzyme Q 10 treatment in alleviating the symptoms of primary coenzyme Q 10 deficiency: A systematic review

(2022) Ying Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure and functionality of a multimeric human COQ7:COQ9 complex

(2022) Mateusz Manicki et al.   MOLECULAR CELL

Small-molecule inhibition of the archetypal UbiB protein COQ8

(2022) Nathan H. Murray et al.   Nature Chemical Biology

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

(2021) Nicholas J. Rossiter et al.   Cell Metabolism

Regulation of coenzyme Q biosynthesis pathway in eukaryotes

(2021) José Manuel Villalba et al.   FREE RADICAL BIOLOGY AND MEDICINE

CYP7A1, NPC1L1, ABCB1, and CD36 Polymorphisms Are Associated with Increased Serum Coenzyme Q10 after Long-Term Supplementation in Women

(2021) Michiyo Takahashi et al.   Antioxidants

Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics

(2021) Juan M. Suárez-Rivero et al.   Antioxidants

Secondary CoQ 10 deficiency, bioenergetics unbalance in disease and aging

(2021) Plácido Navas et al.   BIOFACTORS

The multiple roles of coenzyme Q in cellular homeostasis and their relevance for the pathogenesis of coenzyme Q deficiency

(2021) Elisa Baschiera et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional segmentation of CoQ and cyt c pools by respiratory complex superassembly

(2021) Pablo Hernansanz-Agustín et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

(2021) Marlies P. Rossmann et al.   SCIENCE

Metabolic channeling: predictions, deductions, and evidence

(2021) Vidhi Pareek et al.   MOLECULAR CELL

The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway

(2021) Robert S. Banh et al.   NATURE

UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae

(2021) Zachary A. Kemmerer et al.   Nature Communications

Coenzyme Q Biosynthesis: An Update on the Origins of the Benzenoid Ring and Discovery of New Ring Precursors

(2021) Lucía Fernández-del-Río et al.   Metabolites

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

(2021) Jessica B. Spinelli et al.   SCIENCE

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

(2021) Anita Ayer et al.   Redox Biology

Regulation of hepatic coenzyme Q biosynthesis by dietary omega-3 polyunsaturated fatty acids

(2021) Lucía Fernández-del-Río et al.   Redox Biology

Systems Biochemistry Approaches to Defining Mitochondrial Protein Function

(2020) Andrew Y. Sung et al.   Cell Metabolism

Mutation of the Atypical Kinase ABC1K3 Partially Rescues the PROTON GRADIENT REGULATION 6 Phenotype in Arabidopsis thaliana

(2020) Thibaut Pralon et al.   Frontiers in Plant Science

Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism

(2020) David Mantle et al.   Antioxidants

The mandelate pathway, an alternative to the PAL pathway for the synthesis of benzenoids in yeast.

(2020) Maria Jose Valera et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae

(2020) Lucía Fernández-del-Río et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations

(2020) Ying Wang et al.   Redox Biology

The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification

(2020) Robert A. Heaton et al.   Journal of Clinical Medicine

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

(2020) Jian-Wei Hao et al.   Nature Communications

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis

(2019) Danielle C. Lohman et al.   MOLECULAR CELL

Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER–mitochondria contacts

(2019) Kelly Subramanian et al.   JOURNAL OF CELL BIOLOGY

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function

(2019) Hui S. Tsui et al.   JOURNAL OF LIPID RESEARCH

The mitochondrial intermembrane space–facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism

(2019) Fenja Odendall et al.   MOLECULAR BIOLOGY OF THE CELL

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization

(2018) Ignacio Arias-Mayenco et al.   Cell Metabolism

Clinical syndromes associated with Coenzyme Q 10 deficiency

(2018) María Alcázar-Fabra et al.   Essays in Biochemistry

Multi-omics Reveal Specific Targets of the RNA-Binding Protein Puf3p and Its Orchestration of Mitochondrial Biogenesis

(2018) Christopher P. Lapointe et al.   Cell Systems

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome

(2018) Marco Spinazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenicity of two COQ7 mutations and responses to 2,4-dihydroxybenzoate bypass treatment

(2017) Ying Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multi-omic Mitoprotease Profiling Defines a Role for Oct1p in Coenzyme Q Production

(2017) Mike T. Veling et al.   MOLECULAR CELL

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis

(2017) Jonathan A. Stefely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency

(2017) Fabien Pierrel   Frontiers in Physiology

Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

(2017) David Ross et al.   Frontiers in Physiology

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function

(2016) Brendan J. Floyd et al.   MOLECULAR CELL

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity

(2016) Jonathan A. Stefely et al.   MOLECULAR CELL

Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling

(2016) Jonathan A Stefely et al.   NATURE BIOTECHNOLOGY

Identification of Coq11, a New Coenzyme Q Biosynthetic Protein in the CoQ-Synthome inSaccharomyces cerevisiae

(2015) Christopher M. Allan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of primary ubiquinone deficiency due to a novelCOQ7defect using 2,4–dihydroxybensoic acid

(2015) Christoph Freyer et al.   JOURNAL OF MEDICAL GENETICS

Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis

(2015) Jonathan A. Stefely et al.   MOLECULAR CELL

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

(2015) Ying Wang et al.   Nature Communications

Glucose-Regulated Phosphorylation of the PUF Protein Puf3 Regulates the Translational Fate of Its Bound mRNAs and Association with RNA Granules

(2015) Chien-Der Lee et al.   Cell Reports

Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake

(2015) Courtney M. Anderson et al.   Cell Reports

Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants

(2014) Cuiwen H. He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice

(2014) Kazuhide Takahashi et al.   EXPERIMENTAL GERONTOLOGY

CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins

(2014) Jie Gao et al.   JOURNAL OF CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis

(2014) D. C. Lohman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Overexpression of the Coq8 Kinase inSaccharomyces cerevisiae coqNull Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6Biosynthetic Pathway

(2012) Letian X. Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABC1K atypical kinases in plants: filling the organellar kinase void

(2012) Peter K. Lundquist et al.   TRENDS IN PLANT SCIENCE

Coenzyme Q Biosynthesis: Coq6 Is Required for the C5-Hydroxylation Reaction and Substrate Analogs Rescue Coq6 Deficiency

(2011) Mohammad Ozeir et al.   CHEMISTRY & BIOLOGY

4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures

(2010) Ulrika Forsman et al.   Nature Chemical Biology

Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae

(2009) Sergio Padilla-López et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cell Survival from Chemotherapy Depends on NF-κB Transcriptional Up-Regulation of Coenzyme Q Biosynthesis

(2009) Gloria Brea-Calvo et al.   PLoS One

The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1

(2008) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES