Article
Engineering, Biomedical
Xianqi Zhu, Lin Li, Jin Tang, Chunyu Yang, Hao Yu, Kunpeng Liu, Ziyan Zheng, Xinggui Gu, Qingsong Yu, Fu-Jian Xu, Zhihua Gan
Summary: In this study, a smart photothermal-chemo therapeutic nano-assembly system was developed to target cancer stem cells (CSCs). By modifying the surface of the nano-assembly, the physiological barriers for CSC targeting were overcome. The nano-assembly effectively eliminated both CSCs and non-CSCs, inhibiting tumor growth and metastasis.
Article
Chemistry, Multidisciplinary
Shuang Liu, Tianshu Zhang, Shanshan Li, Qingyuan Wu, Kexin Wang, Xican Xu, MingZhu Lu, Rongguang Shao, Wuli Zhao, Huiyu Liu
Summary: This study reports a nanotherapeutic strategy based on MnOx-loaded polydopamine (MnOx/PDA) nanobombs with chemodynamic, photodynamic, photothermal, and biodegradation properties to simultaneously inhibit cancer stem cells (CSCs) and non-CSCs. The MnOx/PDA nanobombs can directly disrupt the microenvironment and tumorigenic capacity of CSCs by generating hyperthermia, oxidative stress, and alleviating hypoxia. Additionally, they can directly ablate the bulk tumor cells, cutting off the supply of CSCs transformation. The synergistic therapy achieved a tumor inhibition rate of 70.8% in a colorectal cancer (CRC) model.
Article
Medicine, Research & Experimental
Xia Liu, Valery Adorno-Cruz, Ya-Fang Chang, Yuzhi Jia, Madoka Kawaguchi, Nurmaa K. Dashzeveg, Rokana Taftaf, Erika K. Ramos, Emma J. Schuster, Lamiaa El-Shennawy, Dhwani Patel, Youbin Zhang, Massimo Cristofanilli, Huiping Liu
Summary: Research has shown that inhibiting EGFR can block the circulating cancer stem cell (cCSC) clustering and lung metastasis of triple-negative breast cancer (TNBC). In addition to CD44, microRNA-30c also plays a negative regulatory role in cCSC clustering and lung metastasis.
Article
Medicine, Research & Experimental
Xiaofei She, Yaqun Gao, Yan Zhao, Yue Yin, Zhewen Dong
Summary: The study established a simple and repeatable high-throughput CSC inhibitor screening platform, successfully identifying candidate compounds that inhibit tumor sphere formation. Further experiments showed that these compounds completely inhibited the self-renewal of CSCs via their targets in vitro and suppressed lung cancer metastasis in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Amira M. Gamal-Eldeen, Amani A. Alrehaili, Afaf Alharthi, Bassem M. Raafat
Summary: This study found that Perftoran (R) acts as an oxygen carrier and can lower the resistance of lung cancer cells to carboplatin by suppressing hypoxia pathway mediators and the drug resistance transporter MRP-2, and inducing DNA/carboplatin adduct formation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiatao Yang, Qiuyi Li, Minglu Zhou, Xiang Li, Yuan Huang, Nan Yang, Zhou Zhou
Summary: Mitochondria play a crucial role in mitigating cancer metastasis, while the concurrent impairment of nucleus and mitochondria may achieve better anti-tumor effects. This study showed that the combination of targeting both organelles resulted in significant suppression of tumor growth and metastasis in breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Jun-Nian Zhou, Biao Zhang, Hai-Yang Wang, Dong-Xing Wang, Ming-Ming Zhang, Min Zhang, Xiao-Kui Wang, Shi-Yong Fan, Ying-Chen Xu, Quan Zeng, Ya-Li Jia, Jia-Fei Xi, Xue Nan, Li-Juan He, Xin-Bo Zhou, Song Li, Wu Zhong, Wen Yue, Xue-Tao Pei
Summary: The compound phenyl-2-pyrimidinyl ketone 4-ally)-3-amino selenourea (CU27) shows inhibitory effects on cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) by inhibiting the transcription activity of c-Myc, suggesting its potential as a therapeutic for sorafenib-resistant HCC.
Article
Environmental Sciences
Junyi Pan, Yueguang Xue, Shilin Li, Liuxiang Wang, Jie Mei, Dongqi Ni, Jipeng Jiang, Meng Zhang, Shaoqiong Yi, Rong Zhang, Yongfu Ma, Yang Liu, Ying Liu
Summary: This study focuses on the impact of PM2.5 on lung adenocarcinoma and finds that chronic exposure to PM2.5 promotes tumor occurrence and metastasis, with more severe effects in Shijiazhuang. The underlying mechanisms involve the stem cell properties of cancer cells, the epithelial-mesenchymal transition process, and related miRNAs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Marina Ibragimova, Matvey Tsyganov, Nikolai Litviakov
Summary: This review discusses the main mechanisms of CSCs in breast cancer, including markers and signaling pathways, heterogeneity, plasticity, and ecological behavior. The study also considers the significance of dynamic heterogeneity of CSCs and dynamic transitions between CSCs and non-CSCs for metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang, Kunning Yang, Xiaoshan Cai, Hanyue Li, Zhiqin Gao, Meihua Qu
Summary: XPC expression levels in lung adenocarcinoma have been found to influence patients' prognosis and inhibit tumor invasion and metastasis by regulating the stemness of lung cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Lin Mao, Jin Chen, Xue Lu, Canlin Yang, Yi Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu, Yueying Yang, Yunyun Gu, Fei Gao, Junxing Huang, Lujian Liao
Summary: It was found that BCAT1 plays a crucial role in promoting lung cancer cell metastasis, with its overexpression related to tumor metastasis and prognosis. Knocking down BCAT1 expression can reduce the migration of metastatic cells and their ability to metastasize to distant organs.
Article
Obstetrics & Gynecology
Wenwen Wang, Hongjun Guo, Shengyu Wu, Shuyuan Xian, Weiwei Zhang, Ruitao Zhang, Zhihua Chen, Ke Su, Ying Zhang, Ying Zhu, Danxia Chu, Mengling Zhao, Zhihua Tang, Chunlan Zheng, Zongqiang Huang, Qian Ma, Ruixia Guo
Summary: This study aimed to investigate the correlation between ovarian cancer metastasis and cancer stemness. Through analyzing RNA-seq data and clinical information from TCGA, differentially expressed genes (DEGs) and transcription factors (DETFs) were identified. Stemness-related genes (SRGs) and prognostic SRGs (PSRGs) were defined and integrated into a metastasis-specific regulation network. Single cell RNA sequencing data and validation experiments were used to explore the molecular regulation mechanism and validate the key stemness-related signatures. A prognostic prediction model for metastatic ovarian cancer was constructed and potential inhibitors of stemness-related signatures were identified.
REPRODUCTIVE SCIENCES
(2023)
Review
Medicine, Research & Experimental
Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Nasrin Zare Zavieyh Jaghi
Summary: Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to cancer cell metastasis. Autophagy has recently gained attention, playing a dual role in cancer cell development depending on cancer type, tissue, and stage. Studies show different signaling pathways are involved in cancer stem cells, autophagy, and EMT. Investigating effective signaling pathways in all three processes could help determine appropriate therapeutic goals.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
Carina Colturato-Kido, Rayssa M. Lopes, Hyllana C. D. Medeiros, Claudia A. Costa, Laura E. L. Prado-Souza, Leticia S. Ferraz, Tiago Rodrigues
Summary: Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder affecting children and adults, with drug resistance posing a significant clinical problem. Antipsychotic phenothiazines are being explored as potential antitumor drugs, with a focus on inducing autophagy-associated cell death to improve treatment outcomes.
Article
Multidisciplinary Sciences
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L. Bramhall, Tai-Ping Fan, Andreas Bender
Summary: Resistance to current therapies is common in pancreatic cancer, necessitating novel treatment options. A computational method was developed to select synergistic compound combinations based on transcriptomic profiles and pathway scoring system, successfully identifying effective compound combinations against pancreatic cancer cells.
Article
Chemistry, Medicinal
Qing-Xin Wang, Yu-Hao Cao, Li-Jin Yang, Yi-Yuan Ma, Nan Li, Shi-Han Wu, Lu Chen, Jia-Zhen Wu, Zhen-Jiang Tong, Xiao-Long Wang, Xin Xue, Ning Ding, Xue-Jiao Leng, Liang Chang, Wei-Chen Dai, Yan-Cheng Yu, Shan-Liang Sun, Ye Yang, Nian-Guang Li, Zhi-Hao Shi
Summary: This study used computational methods to compare pocket similarity among 269 kinases, and then synthesized a series of 6-methyl-isoxazol[3,4-b]pyridine-3-amino derivatives based on these investigations. Compound 45 displayed potent inhibitory activity against FLT3 internal tandem duplications mutation and FLT3 internal tandem duplications-tyrosine kinase domain-transformed BaF3 cells. The integrated biological activity results suggest that compound 45 deserves further development as a therapeutic remedy for AML.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Hongle Xie, Tianchen Deng, Jingchuan Wang, Weidong Chen
Summary: This study aims to solve the challenging problem of robust long-term visual localization for mobile robots in changing environments. A feature existence state (FES) matrix is designed to measure the evolution of time-varying changes, and an adaptive online stochastic learning (AOSL) method is proposed to model and predict the changing regularities of streaming feature states. Leveraging this method, a lightweight and robust long-term topological localization system is developed.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Immunology
Yiming Li, Jing Zhang, Pan Zhai, Chang Liu, Jinmeng Suo, Jing Wang, Chang Liu, Zhiyong Peng
Summary: This study conducted bulk RNA sequencing to analyze septic acute kidney injury (AKI), revealing differentially expressed genes (DEGs) mainly related to inflammatory response and metabolic processes. Further investigations identified TIFA and FASN as differentially expressed genes in the urine of sepsis-induced AKI patients. TIFA was found to activate pyroptosis through mitochondrial damage, suggesting its potential as a therapeutic target for sepsis-induced kidney injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Yefan Shi, Junhua Li, Luping Gu, Yujie Su, Wangying Chen, Ming Zhang, Cuihua Chang, Yanjun Yang
Summary: Overconsumption of fat-rich foods has caused a significant increase in chronic diseases in humans. This study used egg white protein microparticle, xanthan gum, and gum arabic as additives to develop a low-fat mayonnaise. The results showed that xanthan gum and gum arabic had a synergistic effect on modifying the viscosity and recovery of the low-fat mayonnaise. Xanthan gum effectively increased the viscosity through electrostatic binding with the egg white protein microparticle, and the combination with gum arabic improved recovery by intervening in intermolecular interactions.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yingnan Yang, Yingjie Yang, Chunlin He, Yuezhou Wei, Toyohisa Fujita, Guifang Wang, Shaojian Ma, Wenchao Yang
Summary: In order to effectively separate and recover Co(II) from the leachate of spent lithium-ion battery cathodes, solvent extraction with quaternary ammonium salt N263 in the sodium nitrite system was investigated. The extraction of Co(II) is related to the concentration of NO2-. The maximum extraction efficiency of Co(II) reached 99.16%. After counter-current extraction using the McCabe-Thiele diagram, the extraction efficiency of Co(II) exceeded 99.00% with Co(II) concentration of 2544 mg/L. The back-extraction efficiency of Co(II) achieved 91.41% under specific conditions.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2023)
Article
Materials Science, Biomaterials
Jie Mao, Yalei Liu, Lijun Chen, Sui Wang
Summary: In this study, PVA/BDA/ADH gels with excellent mechanical properties and self-healing capabilities were prepared using PVA, BDA, and ADH. The hydrogel network achieved chemical-physical double cross-linking through acylhydrazone bonds and hydrogen bonds. The resulting PVA/BDA/ADH gels exhibited superior mechanical properties and more stable self-healing properties compared to pure PVA hydrogel.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Agriculture, Multidisciplinary
Tingxuan Zhuang, Yu Zhang, Dong Li, Urs Schmidhalter, Syed Tahir Ata-UI-Karim, Tao Cheng, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao
Summary: This study aims to improve the performance of wavelet analysis in winter wheat water status monitoring by combining machine learning algorithms. The results showed that the random forest and support vector machine models based on multiple sensitive wavelet features achieved the best prediction accuracy for canopy water content, plant water content, and canopy equivalent water thickness. This research is significant for water stress diagnosis and precise irrigation management of winter wheat.
PRECISION AGRICULTURE
(2023)
Article
Chemistry, Applied
Xinqi Wang, Lijiu Cao, Yue Hu, Yufang Chen, Tao Jin, Jian Huang, Xinhe Zhang, Shudong Lin
Summary: In recent years, the application of highly transparent hydrophobic coatings has been a focus in preventing smudging on electronic displays, automotive glass surfaces, and solar cell surfaces. This study developed a novel hydrophobic melamine resin by modifying melamine with stearyl chloride, leading to the fabrication of high-transparency hydrophobic coatings. The incorporation of long-chain alkyl materials and polyethylene glycol improved the surface properties and flexibility of the resin.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Engineering, Geological
Chao Wei, Shucai Li, Liyuan Yu, Bo Zhang, Richeng Liu, Dongdong Pan, Fengling Zhang
Summary: Pulse hydraulic fracturing is an effective technique for rock fracturing and stimulation, but the characteristics of rock strength deterioration and fracture mechanisms under different pulse hydraulic pressures are not well understood. This study investigates the strength deterioration of rocks under different pulse hydraulic pressures and establishes a fracture damage deterioration model, which is validated by experimental results.
ROCK MECHANICS AND ROCK ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Xu Shan, Bin Miao, Zhe Cao, ZhenYu Sun, YiRen Li, Kai Liu, XingYu Guo, SanBiao Qu, ZhenPeng Su, ChengLong Shen, ZongHao Pan, Xin Li, XinJun Hao, XiaoPing Yang, Chao Tian, Yu Jiang, ShuBin Liu, Qi An, XiangJun Chen, YuMing Wang
Summary: On June 23, 2020, a Chinese geosynchronous satellite was launched, which carried a plasma detection package to monitor the space environment. The low energy ion spectrometer (LEIS), one of the primary instruments in the package, demonstrated three-dimensional measurement of ions in space with a large field of view and wide energy range. The observations revealed clear signatures of surface charging and storm/substorm ion injections, providing valuable insights into the space ion environment and aiding in space weather forecasting.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Lin Wang, Yuyan Liu, Yiwei Zhang, Siwen Chen, Niuniu Zhang, Zefeng Wang, Haofeng Liu
Summary: In this study, the potential ecological risks posed by PAEs in the Dongzhaigang water body were investigated. The results showed that most types of PAEs in water posed low risk to organisms, but certain organisms such as algae, crustaceans, and fish were at medium to high risk. DEHP, in particular, posed high risk to algae, crustaceans, and fish. The potential ecological risk of PAEs in sediments was found to be more stable compared to that in water bodies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Chemical
Rui Xu, Jie Liu, Wei Sun, Li Wang
Summary: In this study, the flotation behaviors and mechanisms of mixed sodium dodecylsulfonate (SDS)/dodecylamine (DDA) collectors on biotite surface were systematically investigated. The results showed that the recovery of biotite increased to above 90% with the addition of mixed collectors at alkaline pH, while the recovery of quartz was below 10%.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hongyan Ji, Xiao Wang, Xiaoxu Wei, Yuxuan Peng, Shuaishuai Zhang, Shuyan Song, Hongjie Zhang
Summary: Hydrogenolysis is an effective method for converting polyolefins into high-value chemicals. In this study, the activity of CeO2-supported Ru single atoms, nanoclusters, and nanoparticles in LDPE hydrogenolysis showed a volcanic trend. Metal-support interactions and hydrogen spillover effect were identified as the two key factors in the reaction. Only when the balance between these two effects is achieved, as in CeO2-supported Ru nanoclusters, can the hydrogenolysis activity be promoted.
Article
Soil Science
Jiayu Shi, Jirui Gong, Xiaobing Li, Zihe Zhang, Weiyuan Zhang, Ying Li, Liangyuan Song, Siqi Zhang, Jiaojiao Dong, Taoge-tao Baoyin
Summary: Anthropogenic activities have raised concerns about the sustainability of phosphorus (P) globally. In a 2-year field experiment in northern China, we examined the effects of inorganic P fertilization on soil P dynamics in a temperate grassland. Phosphorus fertilizer was applied annually before the growth period. We analyzed soil properties, microbial community, extracellular enzyme activities, and soil P fractions using P-31 NMR spectroscopy. The results showed that P application promoted the conversion of organic P to inorganic P, driven by microbial carbon (C) demand, and influenced by soil properties and microbial characteristics. The addition of P decreased orthophosphate diesters, especially DNA, due to increased hydrolysis under increased soil pH. Orthophosphate monoesters, particularly myo-inositol hexaphosphate, also decreased following increased P availability, attributed to increased alkaline phosphatase activity and reduced sorption due to decreased metal content. Additionally, P fertilization increased soil NH4+-N, promoting the growth of phosphonate-solubilizing microorganisms, which contributed to inorganic P solubilization and organic P mineralization. Overall, these findings highlight the complex mechanisms underlying soil P dynamics and the role of P fertilization in regulating P availability in grassland ecosystems.
SOIL & TILLAGE RESEARCH
(2023)
Article
Plant Sciences
Ying Wang, Le Yang, Xiwu Zhang, Ye Sun, Hui Sun, Guangli Yan, Qiqi Zhao, Ying Han, Xijun Wang
Summary: This study identified the effective constituents and quality markers of a traditional Chinese medicine decoction for the treatment of primary dysmenorrhoea. The identified markers can be used for quality control and drug innovation, and facilitate industrialization development.
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)
