Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis

Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study

(2022) Feng-Ru Huang et al.   ARCHIVES OF TOXICOLOGY

NLRP3 as a sensor of metabolism gone awry

(2021) Emilia Neuwirt et al.   CURRENT OPINION IN BIOTECHNOLOGY

NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword

(2020) Shaima'a Hamarsheh et al.   Frontiers in Immunology

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Factors Influencing Imatinib-Induced Hepatotoxicity

(2019) Ji Min Han et al.   Cancer Research and Treatment

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

(2019) Inbar Shlomovitz et al.   Cell Communication and Signaling

Charcot–Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages

(2018) Juan Francisco Rodríguez-Alcázar et al.   JOURNAL OF IMMUNOLOGY

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation

(2017) Gregory M. Orlowski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

(2016) H. Agerstam et al.   BLOOD

Secretion of IL-1β from imatinib-resistant chronic myeloid leukemia cells contributes toBCR-ABLmutation-independent imatinib resistance

(2016) Cho-Rong Lee et al.   FEBS LETTERS

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Immunological off-target effects of imatinib

(2016) Laurence Zitvogel et al.   Nature Reviews Clinical Oncology

Therapeutic drug monitoring and tyrosine kinase inhibitors

(2016) Pauline Herviou et al.   Oncology Letters

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

(2016) Te-Chen Tzeng et al.   Cell Reports

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

(2015) Rahul Palchaudhuri et al.   Cell Reports

Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

(2014) Ana M. Villamil Giraldo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

(2014) Jürgen Brojatsch et al.   PLoS One

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug

(2009) B. Chapuy et al.   HAEMATOLOGICA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One

Streptococcus pyogenesinduces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway

(2008) Oliver Goldmann et al.   CELLULAR MICROBIOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY