Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease

Long-term maintenance of dystrophin expression and resistance to injury of skeletal muscle in gene edited DMD mice

(2022) Dileep R. Karri et al.   Molecular Therapy-Nucleic Acids

CRISPR Modeling and Correction of Cardiovascular Disease

(2022) Ning Liu et al.   CIRCULATION RESEARCH

In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

(2021) Luke W. Koblan et al.   NATURE

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

(2021) Kiran Musunuru et al.   NATURE

Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing

(2021) F. Chemello et al.   Science Advances

CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

(2021) Qinchuan Wang et al.   Nature Communications

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

(2021) Jennifer S. Lawton et al.   CIRCULATION

Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control

(2021) Guangyu Zhang et al.   CIRCULATION

Enhanced CaMKII-Dependent Late I Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing

(2020) Simon Lebek et al.   CIRCULATION RESEARCH

Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart

(2020) Drew Nassal et al.   Frontiers in Pharmacology

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

(2020) Jonathan M. Levy et al.   Nature Biomedical Engineering

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

(2020) Michelle F. Richter et al.   NATURE BIOTECHNOLOGY

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

(2020) Russell T. Walton et al.   SCIENCE

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

(2019) Tony P. Huang et al.   NATURE BIOTECHNOLOGY

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair

(2019) Mao Zhang et al.   NATURE CELL BIOLOGY

In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

(2019) Leonela Amoasii et al.   Nature Communications

Physiological and unappreciated roles of CaMKII in the heart

(2018) Jan Beckendorf et al.   BASIC RESEARCH IN CARDIOLOGY

The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity

(2018) S. Lebek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

(2018) Luke W Koblan et al.   NATURE BIOTECHNOLOGY

CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens

(2018) Jean-Paul Concordet et al.   NUCLEIC ACIDS RESEARCH

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy

(2018) Leonela Amoasii et al.   SCIENCE

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

KN-93 inhibits IKr in mammalian cardiomyocytes

(2015) Bence Hegyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

CaMKII inhibitors: from research tools to therapeutic agents

(2014) Patricia Pellicena et al.   Frontiers in Pharmacology

Oxidized Ca 2+ /Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation

(2013) Anil Purohit et al.   CIRCULATION

Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-κB

(2013) Haiyun Ling et al.   CIRCULATION RESEARCH

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

(2013) Min Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

Design and validation of Segment - freely available software for cardiovascular image analysis

(2010) Einar Heiberg et al.   BMC MEDICAL IMAGING

The   isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

(2009) J. Backs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL