Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism

Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis

(2022) Wen-Rui Wu et al.   ONCOGENE

Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple‐negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways

(2021) Shan Zhu et al.   Cancer Cell International

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression

(2021) Kaname Sakamoto et al.   Oncogenesis

A circular network of coregulated sphingolipids dictates lung cancer growth and progression

(2021) Qiong Meng et al.   EBioMedicine

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

(2021) Camilla M. Reehorst et al.   DEVELOPMENT

Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities

(2021) Ya-Ming Meng et al.   Nature Communications

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt

(2020) Stephanie Schwalm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

(2020) Shai White‐Gilbertson et al.   Cancer Medicine

Overcoming Endocrine Resistance in Breast Cancer

(2020) Ariella B. Hanker et al.   CANCER CELL

Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells

(2020) Lama Hamadneh et al.   Scientific Reports

Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110

(2020) Yitian Chen et al.   CANCER LETTERS

A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway

(2019) Wei-Chieh Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

(2018) Otto Kauko et al.   Science Translational Medicine

Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1

(2018) Yinghua Zhu et al.   Nature Communications

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells

(2016) Io-Guané Rivera et al.   BIOCHEMICAL PHARMACOLOGY

Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer

(2016) Jing Shi et al.   Cell Death & Disease

Tamoxifen regulation of sphingolipid metabolism—Therapeutic implications

(2015) Samy A.F. Morad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death

(2014) Oleksandr Pastukhov et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

C2-Ceramide Induces Cell Death and Protective Autophagy in Head and Neck Squamous Cell Carcinoma Cells

(2014) Wenyuan Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer

(2014) P-P Wong et al.   ONCOGENE

Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells

(2013) Samy A.F. Morad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial

(2012) Christina Davies et al.   LANCET

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

(2010) Y. Zhao et al.   CANCER RESEARCH

Ceramide and ceramide 1-phosphate in health and disease

(2010) Lide Arana et al.   Lipids in Health and Disease

Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition

(2010) C Ji et al.   ONCOGENE

Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways

(2007) Patricia Gangoiti et al.   CELLULAR SIGNALLING