Article
Chemistry, Multidisciplinary
Xuebin Ma, Xuncheng Yang, Mengqi Li, Jiwei Cui, Peiyu Zhang, Qun Yu, Jingcheng Hao
Summary: The elasticity of nanoparticles affects their cellular interactions, with stiff capsules showing higher cellular uptake compared to soft capsules, and influencing the uptake pathways.
Article
Genetics & Heredity
Brian T. Emmer, Emily J. Sherman, Paul J. Lascuna, Sarah E. Graham, Cristen J. Willer, David Ginsburg
Summary: Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease, with LDL receptor-mediated endocytosis playing a key role in regulating cholesterol homeostasis. Genome-scale CRISPR screening identified several genes involved in LDL uptake and revealed their functional interaction mechanisms with LDLR.
Article
Biochemistry & Molecular Biology
Anna Avino, Anna Clua, Maria Jose Bleda, Ramon Eritja, Carme Fabrega
Summary: Conjugation of small molecules with short oligonucleotides is used to enhance the pharmacological properties of anti-cancer drugs. The study found that palmitic acid and folic acid conjugates showed the highest antiproliferative activity, while cholesterol oligomers, despite being well-internalized, had poor anti-cancer activity. These results are significant for delivering therapeutic oligonucleotides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Hyoung-Jun Kim, Sung Hoon Kim, Hyoung-Mi Kim, Yoon Suk Kim, Jae-Min Oh
Summary: LDH particles with uniform size were prepared via hydrothermal method and introduced with fluorescein moiety; through ion-exchange and reconstruction, LDH particles with smooth and rough surfaces were obtained; experimental results showed that smooth-surfaced LDH had advantages in cellular uptake, possibly due to their higher protein adsorption property.
APPLIED CLAY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ahmad Sohrabi Kashani, Muthukumaran Packirisamy
Summary: Understanding the unknown mechanobiological responses to nano-bio-interaction is crucial in designing safe and effective nanomedicines. Studies have shown that the mechanobiological properties of cells, such as elasticity and adhesion, play key roles in cellular functions and cancer progression. Monitoring the mechanobiological responses of treated cells can help evaluate the efficiency of nanomedicines and develop applications to modulate cell mechanics for controlling cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Vasileios Papalazarou, Oliver D. K. Maddocks
Summary: Nutrient supply and demand play a crucial role in shaping cell behavior in health and disease, with mammalian cells employing various strategies to obtain necessary nutrients for metabolic needs. Disruption of homeostasis, as seen in conditions like cancer, can lead to increased proliferation rates in energetically challenging environments where nutrient sources are limited.
Article
Food Science & Technology
Jia Ying Wang, Youjin Baek, Eun Woo Jeong, Hyeon Gyu Lee
Summary: This study focuses on optimizing the preparation conditions of CoQ10-loaded liposomes to overcome the limitations of conventional liposomes. The study evaluates the concentrations of cholesterol and beta-sitosterol, as well as CoQ10, and their effects on particle size and entrapment efficiency. The study also investigates how these components impact the stability, adhesion property, and antioxidant activity of the liposomes. The findings suggest that beta-sitosterol has the potential to enhance the physicochemical attributes of CoQ10-loaded liposomes, proposing applications in the food and pharmaceutical industries.
Article
Chemistry, Multidisciplinary
Bryan E. White, Molly K. White, Zeid A. Nima Alsudani, Fumiya Watanabe, Alexandru S. Biris, Nawab Ali
Summary: This study investigates the uptake mechanism and localization of gold nanorods in SKBR-3 and MCF-7 breast cancer cell lines. The results demonstrate differences and similarities in the interaction between nanorods and cells of the two cell lines. The cellular uptake of gold nanorods in SKBR-3 and MCF-7 was accurately quantified using ICP-MS, and the intracellular nanoparticle localization was qualitatively tracked using transmission electron microscopy.
Article
Chemistry, Multidisciplinary
Marco Cassani, Soraia Fernandes, Jorge Oliver-De La Cruz, Helena Durikova, Jan Vrbsky, Marek Patocka, Veronika Hegrova, Simon Klimovic, Jan Pribyl, Doriana Debellis, Petr Skladal, Francesca Cavalieri, Frank Caruso, Giancarlo Forte
Summary: This study investigates the role of cellular mechanosensitive components in cell-nanoparticle interactions. It is shown that the inhibition of YAP protein improves nanoparticle internalization in triple-negative breast cancer cells.
Article
Chemistry, Multidisciplinary
Felista L. Tansi, Filipp Froebel, Wisdom O. Maduabuchi, Frank Steiniger, Martin Westermann, Rainer Quaas, Ulf K. Teichgraeber, Ingrid Hilger
Summary: The study investigated the impact of matrix-modulating enzymes on the uptake of magnetic nanoparticles by pancreatic cancer cells and their overall influence on magnetic heating and cell death. Results showed that hyaluronidase enhanced the uptake of magnetic nanoparticles, leading to improved thermal treatment outcomes.
Article
Chemistry, Multidisciplinary
Anna K. Blakney, Polina Deletic, Paul F. McKay, Clement R. Bouton, Marianne Ashford, Robin J. Shattock, Alan Sabirsh
Summary: This study explores the effects of different lipid formulations on mRNA uptake and expression in human skin explants, finding that adipocytes efficiently express mRNA and contribute significantly to total RNA-encoded protein expression. Other cell types also increase mRNA expression over 72 hours, regardless of lipid formulation. The overall charge of particles, rather than the lipid classification, predicts the pattern of mRNA uptake and expression among resident cell types.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, Research & Experimental
Claudia Silva, Nelson Andrade, Ilda Rodrigues, Antonio Carlos Ferreira, Miguel Luz Soares, Fatima Martel
Summary: The study reveals that IFN-γ and insulin can increase glutamine uptake by breast cancer and non-tumorigenic cells, respectively, through an ASCT2-dependent mechanism. Effective inhibition of ASCT2-mediated glutamine uptake may serve as a therapeutic strategy against breast cancer in T2DM patients.
Article
Biochemistry & Molecular Biology
Maria Blaszczyk, Agata Koziol, Anna Palko-Labuz, Kamila Sroda-Pomianek, Olga Wesolowska
Summary: Cholesterol is an important component of mammalian cell membranes, and together with sphingomyelin, it forms lipid rafts, which play a role in signal transduction. Altered cholesterol levels are associated with various diseases. This study investigated compounds that affect cellular cholesterol homeostasis. These compounds were found to be cytotoxic to colon cancer cells and decreased cellular cholesterol levels. The interaction of these compounds with model membranes was visualized, and certain compounds were found to affect the size and shape of lipid domains. The importance of membrane interactions for the anticancer potency of these compounds, especially betulin derivatives, was suggested.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Chemistry, Multidisciplinary
Ricardo J. B. Pinto, Nicole S. Lameirinhas, Gabriela Guedes, Gustavo H. Rodrigues da Silva, Parastu Oskoei, Stefan Spirk, Helena Oliveira, Iola F. Duarte, Carla Vilela, Carmen S. R. Freire
Summary: This study investigates CNCs and CS derivative-based nanosystems for potential cancer treatment, demonstrating the stability and non-toxicity of fluorescent CNCs/FA-CS-FITC nanosystems in different conditions and their concentration-dependent cellular uptake in breast cancer cells. The functionalized CNCs show a high affinity towards FR-positive cancer cells and have a potential anti-proliferative effect, suggesting their potential applicability as nanocarriers for targeted therapy with imaging properties.
Article
Multidisciplinary Sciences
Jorge Luis Galeano Nino, Hanrui Wu, Kaitlyn D. LaCourse, Andrew G. Kempchinsky, Alexander Baryiames, Brittany Barber, Neal Futran, Jeffrey Houlton, Cassie Sather, Ewa Sicinska, Alison Taylor, Samuel S. Minot, Christopher D. Johnston, Susan Bullman
Summary: The study investigates the interactions between tumor-associated microbiota and host cells in oral squamous cell carcinoma and colorectal cancer using in situ spatial-profiling technologies and single-cell RNA sequencing. The results show that the distribution of microbiota within the tumor is highly organized in microniches with immune and epithelial cell functions, promoting cancer progression.
Article
Materials Science, Multidisciplinary
Hossein Ravanbakhsh, Razyeh Behbahani, Hamidreza Yazdani Sarvestani, Elham Kiyani, Meysam Rahmat, Mikko Karttunen, Behnam Ashrafi
Summary: This study evaluates and assists the design of interlocked ceramics under thermal shock loading using finite-element and machine learning methods. The approach successfully finds the optimal designs among over 2 million cases.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Biophysics
Matthew Davies, A. D. Reyes-Figueroa, Andrey A. Gurtovenko, Daniel Frankel, Mikko Karttunen
Summary: A new method combining mixed radial-angular, three-particle correlation function and unsupervised machine learning was used to investigate the emergence of the ripple phase in DPPC lipid bilayers. Data from atomistic molecular dynamics simulations of varying system sizes were analyzed, revealing four distinct conformational populations of lipids. The presence of ordered, disordered, and splayed tail lipids was observed, with spatial clustering of disordered lipids in the groove side of the ripple phase. Principal component analysis confirmed the existence of the four lipid groups.
BIOPHYSICAL JOURNAL
(2023)
Article
Chemistry, Physical
Dmitry Tolmachev, Victor Nazarychev, Veronika Fedotova, Vitaly Vorobiov, Natalia Lukasheva, Michael Smirnov, Mikko Karttunen
Summary: This study investigates the structure and properties of polymerizable deep eutectic solvents (DESs) based on choline chloride and acrylic acid for 3D printing inks, using multiscale simulations and experiments. The results reveal the physical mechanisms of DES formation and the network-like structure of the mixture with Cl- ions as connecting nodes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Physics, Multidisciplinary
Razyeh Behbahani, Hamidreza Yazdani Sarvestani, Erfan Fatehi, Elham Kiyani, Behnam Ashrafi, Mikko Karttunen, Meysam Rahmat
Summary: Laser machining is a flexible manufacturing technique that relies on simulation methods and machine learning to optimize processing parameters and reduce experimental costs. These techniques can be applied to a variety of ceramic laser machining processes.
Article
Engineering, Environmental
Lei Zhang, Minglu Hao, Liang Yao, Cheng Xing, Qingmei Wen, Zhining Zhang, Jingmou Yu, Jun Wang, Dongming Xing, Tao Zheng, P. Chen
Summary: This study used silk sericin to encapsulate anthocyanins, improving their stability and bioactivity, and investigated the interaction between silk sericin and anthocyanins through experimental and computational methods. The hydrogel formulation of silk sericin showed higher encapsulation efficiency and stability under different conditions. The encapsulated anthocyanins exhibited enhanced bioactivity, particularly in scavenging reactive oxygen species. This study highlights the potential of using two bioactive components from the same source to enhance stability and regulate bioactivity in tissue engineering applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Jingmou Yu, Liangliang Wang, Yun Ling, Xin Xiao, Juntao Gong, Hongguang Jin, Jing Xu, Pu Chen, Xin Xie, Lei Zhang
Summary: In this study, novel polymeric nanoparticles targeting dual receptors and responding to reducing conditions for drug release were developed for the treatment of triple-negative breast cancer. The bioresponsive drug release of the nanoparticles was demonstrated, and it was found that they effectively targeted specific receptors both in vitro and in vivo. The nanoparticles showed higher cytotoxicity and cellular uptake compared to unmodified drug-containing micelles, and they exhibited the strongest suppression of tumor growth in a mouse model. These findings suggest that amphiphilic nanoparticles can serve as a targeted and intelligent delivery vehicle for triple-negative breast cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Multidisciplinary
Elham Kiyani, Khemraj Shukla, George Em Karniadakis, Mikko Karttunen
Summary: This article proposes a framework and algorithm for directly uncovering the unknown parts of nonlinear equations from data. By augmenting the original X-PINN method with flux continuity across domain interfaces, the approach demonstrates excellent accuracy in predicting the unknown part of the equation. The results are further validated through symbolic regression to determine the closed form of the equation's unknown part.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Rohoullah Firouzi, Shahin Sowlati-Hashjin, Cecilia Chavez-Garcia, Mitra Ashouri, Mohammad Hossein Karimi-Jafari, Mikko Karttunen
Summary: The assembly of amyloid-beta peptide (Aβ) into toxic oligomers and fibrils is associated with Alzheimer's disease and dementia. Targeting the monomeric form of Aβ with small molecules or antibodies to disrupt amyloid assembly is a promising therapeutic strategy. This study proposes a computational pipeline, using ensemble docking strategy, to identify catechins' binding sites in monomeric Aβ(42) and explores the crucial interactions for binding. The results suggest that catechins, especially EGCG, can act as potent inhibitors against amyloid aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Carter J. Wilson, Mikko Karttunen, Bert L. de Groot, Vytautas Gapsys
Summary: The stability, solubility, and function of a protein are determined by its net charge and the protonation states of its individual residues. The study demonstrates the applicability of a nonequilibrium alchemical free energy method for accurately predicting pK(a) values, which is comparable to current state-of-the-art predictors. The research also highlights the performance disparity associated with lysine partial charges in certain models and mentions an underused fix for this issue.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Editorial Material
Multidisciplinary Sciences
Vojtech Sadek, Shahin Sowlati-Hashjin, SeyedAbdolreza Sadjadi, Mikko Karttunen, Angel Martin-Pendas, Cina Foroutan-Nejad
NATURE COMMUNICATIONS
(2023)
Review
Engineering, Biomedical
Lei Zhang, Liang Yao, Feng Zhao, Alice Yu, Yueru Zhou, Qingmei Wen, Jun Wang, Tao Zheng, Pu Chen
Summary: Anthocyanin is a natural polyphenol with excellent antioxidant, anticancer, antiaging, antimicrobial, and anti-inflammatory properties. However, its stability and bioavailability are limited in extreme environments. Encapsulating anthocyanin with biomaterials or combining it with proteins and peptides can effectively stabilize it. This review focuses on recent progress, strategies, and perspectives on protein and peptide stabilization of anthocyanin for functionalization and delivery, including formulation technologies, stability enhancement, cellular uptake, bioavailabilities, and biological activities.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Nan He, Jie Yan, Zhining Zhang, Haiming Qin, Ertao Hu, Xinpeng Wang, Hao Zhang, Pu Chen, Feng Xu, Yang Sheng, Lei Zhang, Yi Tong
Summary: In this study, memristive devices with threshold switching characteristics were used to emulate leaky integrate-and-fire neurons. The devices demonstrated excellent electrical properties and were able to successfully emulate multiple neural features. The study also achieved a high accuracy in pattern recognition, highlighting the potential of using biomaterials in advanced neuromorphic computation.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Food Science & Technology
Cheng Xing, P. Chen, Lei Zhang
Summary: This review summarizes the mechanisms of interaction between proteins/peptides and anthocyanins, based on computational approaches, and discusses the current limitations of these methods and suggests possible solutions.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Behnaz Bagheri, Phansiri Boonnoy, Jirasak Wong-ekkabut, Mikko Karttunen
Summary: Oxidized phospholipids have significant effects on the structure and permeability of cell membranes, depending on the degree and concentration of oxidation. Adding PoxnoPC to phospholipid bilayers leads to a reduction in thickness and increased order in the structure, while adding PazePC results in a more significant reduction in thickness and increased disorder. These structural changes enhance the permeability of the bilayers, but the specific effect depends on the type and concentration of the oxidized products.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Chao Yang, Dan Li, Shaohong Zang, Yingtang Zhou, Lei Zhang, Zhangfeng Zhong
Summary: Immune rejection, poor biocompatibility and cytotoxicity hamper the widespread use of biometallic materials. Surface modification has been employed as a general strategy to develop material coatings that can overcome these challenges and achieve successful implant performance. In this study, a substrate surface-modification strategy based on biofilm CsgA proteins was proposed, which promotes rapid cell attachment, proliferation, and stabilization of the cytoskeleton. The CsgA-based nano-coating is easy to fabricate and exhibits superior performance, which is expected to expand the application of medical implants.
CHINESE CHEMICAL LETTERS
(2023)