Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host

Antiplasmodial activity of the natural product compounds alstonine and himbeline

(2021) M.S.J. Arnold et al.   International Journal for Parasitology-Drugs and Drug Resistance

The Mechanism of Ajmaline and Thus Brugada Syndrome: Not Only the Sodium Channel!

(2021) Michelle M. Monasky et al.   Frontiers in Cardiovascular Medicine

Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet–Spengler Reactions

(2020) Elisabeth Eger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Plant-Based Vaccines: The Way Ahead?

(2020) Zacharie LeBlanc et al.   Viruses-Basel

Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs

(2020) Katharine Davis et al.   Frontiers in Plant Science

Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group

(2019) Jonathan Cramer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

(2018) Thu-Thuy T. Dang et al.   Nature Chemical Biology

Engineering terpenoid production through transient expression in Nicotiana benthamiana

(2018) James Reed et al.   PLANT CELL REPORTS

Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

(2018) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

(2018) Lorenzo Caputi et al.   SCIENCE

GB3.0: a platform for plant bio-design that connects functional DNA elements with associated biological data

(2017) Marta Vazquez-Vilar et al.   NUCLEIC ACIDS RESEARCH

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate

(2017) Evangelos C. Tatsis et al.   Nature Communications

The modification of natural products for medical use

(2017) Zongru Guo   Acta Pharmaceutica Sinica B

Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

(2016) Anna Stavrinides et al.   Nature Communications

Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism

(2015) Anna Stavrinides et al.   CHEMISTRY & BIOLOGY

A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence

(2015) Jakub Rajniak et al.   NATURE

Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants

(2015) Guy Polturak et al.   NEW PHYTOLOGIST

Plant-made pharmaceuticals: from ‘Edible Vaccines’ to Ebola therapeutics

(2015) Charles Arntzen   PLANT BIOTECHNOLOGY JOURNAL

Recent advances in combinatorial biosynthesis for drug discovery

(2015) Ee Lui Ang et al.   Drug Design Development and Therapy

The seco-iridoid pathway from Catharanthus roseus

(2014) Karel Miettinen et al.   Nature Communications

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

(2011) Jane Achan et al.   MALARIA JOURNAL

Reactions of Nicotiana species to inoculation with monopartite and bipartite begomoviruses

(2011) Sohail Akhtar et al.   Virology Journal

Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis

(2007) Nancy Yerkes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS