IL-17 driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

(2022) Xun Lin et al.   IMMUNITY

Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense

(2022) Mariko Kamioka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of interferons in gastrointestinal injury repair

(2021) Constance McElrath et al.   Nature Communications

New onset inflammatory bowel disease in patient treated with secukinumab: Case report and review of literature

(2021) Ailia K. Ali et al.   Dermatologic Therapy

Crohn’s-like disease in a patient exposed to anti-Interleukin-17 blockade (Ixekizumab) for the treatment of chronic plaque psoriasis: a case report

(2019) Matthew K. Smith et al.   BMC GASTROENTEROLOGY

An Experimental Approach to Rigorously Assess Paneth Cell α-Defensin (Defa) mRNA Expression in C57BL/6 Mice

(2019) Patricia A. Castillo et al.   Scientific Reports

Acute small intestinal inflammation results in persistent lymphatic alterations

(2018) Sonia Rehal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

(2018) Moshe Biton et al.   CELL

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

The Protective Role of Type I Interferons in the Gastrointestinal Tract

(2017) Kevin P. Kotredes et al.   Frontiers in Immunology

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

(2016) Pawan Kumar et al.   IMMUNITY

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Segmented Filamentous Bacterium Uses Secondary and Tertiary Lymphoid Tissues to Induce Gut IgA and Specific T Helper 17 Cell Responses

(2014) Emelyne Lécuyer et al.   IMMUNITY

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-13-Mediated Paneth Cell Degranulation and Antimicrobial Peptide Release

(2014) Silvia Stockinger et al.   Journal of Innate Immunity

Effect of DNA extraction and sample preservation method on rumen bacterial population

(2013) Katerina Fliegerova et al.   ANAEROBE

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

A histopathologic scoring system as a tool for standardized reporting of chronic (ileo)colitis and independent risk assessment for inflammatory bowel disease

(2012) Bita V. Naini et al.   HUMAN PATHOLOGY

An Alternative Pathway of Imiquimod-Induced Psoriasis-Like Skin Inflammation in the Absence of Interleukin-17 Receptor A Signaling

(2012) Khalifa El Malki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

(2012) Megan Raetz et al.   NATURE IMMUNOLOGY

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

KCNN4 Gene Variant Is Associated With Ileal Crohn's Disease in the Australian and New Zealand Population

(2010) Lisa A Simms et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reduced  -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease

(2008) L A Simms et al.   GUT