The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy

RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing

(2022) Laurence G Webb et al.   Current Opinion in Virology

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

(2021) Seoyun Yum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway

(2021) Yao Liu et al.   ANTIVIRAL RESEARCH

How the Innate Immune DNA Sensing cGAS–STING Pathway Is Involved in Autophagy

(2021) Wanglong Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon

(2021) Jianjun Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

(2020) Katherine R. Balka et al.   Cell Reports

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

(2020) Jianjun Wu et al.   IMMUNITY

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

(2020) Lívia H. Yamashiro et al.   Nature Communications

Chicken DNA Sensing cGAS-STING Signal Pathway Mediates Broad Spectrum Antiviral Functions

(2020) Shuangjie Li et al.   Vaccines

Porcine IFI16 Negatively Regulates cGAS Signaling Through the Restriction of DNA Binding and Stimulation

(2020) Wanglong Zheng et al.   Frontiers in Immunology

STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain

(2020) Tara D. Fischer et al.   JOURNAL OF CELL BIOLOGY

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila

(2020) Hua Cai et al.   Science Signaling

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

(2019) Jianjun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

(2019) Carina C. de Oliveira Mann et al.   Cell Reports

Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain

(2018) Yuan Liu et al.   Cell Host & Microbe

Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-kB activation

(2018) Xiaoting Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING-dependent translation inhibition restricts RNA virus replication

(2018) Kate M. Franz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Mechanisms and pathways of innate immune activation and regulation in health and cancer

(2015) Jun Cui et al.   Human Vaccines & Immunotherapeutics

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

(2013) Liang Ge et al.   eLife

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE