Article
Cardiac & Cardiovascular Systems
Yujie Bai, Mingkai Yun, Binbin Nie, Liang Shan, Wenxian Liu, Marcus Hacker, Shaoping Nie, Yujie Zhou, Sijin Li, Baoci Shan, Xiaoli Zhang, Xiang Li
Summary: This study investigated the interaction between neuronal metabolism and ventricular dyssynchrony in patients with heart failure. The results suggest a potential role of this interaction in major arrhythmic events. This finding expands our understanding of the distinct pathomechanisms of heart failure with reduced ejection fraction (HFrEF).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Amrit S. Lota, Adam Tsao, Ruth Owen, Brian P. Halliday, Dominique Auger, Vassilios S. Vassiliou, Upasana Tayal, Batool Almogheer, Silvia Vilches, Amer Al-Balah, Akhil Patel, Florence Mouy, Rachel Buchan, Simon Newsome, John Gregson, James S. Ware, Stuart A. Cook, John G. F. Cleland, Dudley J. Pennell, Sanjay K. Prasad
Summary: In patients without coronary artery disease and with normal range left ventricular volumes and ejection fraction, late gadolinium enhancement (LGE) was found to have low risk of sudden cardiac death. Mortality was mainly associated with age rather than the presence, location, or extent of LGE.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Sergey V. Nesterov, Johanna Raty, Wail Nammas, Teemu Maaniitty, Xavier Galloo, Jan Stassen, Sanna Laurila, Tuija Vasankari, Jenni Huusko, Jeroen J. Bax, Antti Saraste, Juhani Knuuti
Summary: This study aimed to evaluate the mechanism of ARNI therapy in heart failure patients and compare it with valsartan-only treatment. The results showed that while there were no differences in the energetic efficiency of cardiac work between the two groups, ARNI had haemodynamic and cardiac mechanical effects over valsartan in heart failure patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Kazuhiro Koyanagawa, Masanao Naya, Tadao Aikawa, Osamu Manabe, Sho Furuya, Masato Kuzume, Noriko Oyama-Manabe, Hiroshi Ohira, Ichizo Tsujino, Toshihisa Anzai
Summary: This study found that myocardial perfusion was recovered in 61% and preserved in 8% of patients with cardiac sarcoidosis after steroid therapy. The recovery of myocardial perfusion after steroid therapy was significantly associated with a low incidence of major adverse cardiac events (MACE).
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Review
Medicine, Research & Experimental
Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig
Summary: The connection between HFpEF and MetS suggests that dysregulated lipid metabolism may play a role in causing diastolic dysfunction and subsequent HFpEF.
Article
Multidisciplinary Sciences
Julie K. Shade, Adityo Prakosa, Dan M. Popescu, Rebecca Yu, David R. Okada, Jonathan Chrispin, Natalia A. Trayanova
Summary: The study introduces a two-step precision risk prediction technology for patients with CS, accurately assessing arrhythmogenic propensity and potentially transforming CS risk stratification.
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthew Aitken, Michael Vinchill Chan, Camila Urzua Fresno, Ashley Farrell, Nayaar Islam, Matthew D. F. McInnes, Mark Iwanochko, Meyer Balter, Yasbanoo Moayedi, Paaladinesh Thavendiranathan, Ur Metser, Patrick Veit-Haibach, Kate Hanneman
Summary: This study compared the diagnostic accuracy of cardiac MRI and FDG PET for cardiac sarcoidosis. The results showed that cardiac MRI had higher sensitivity than FDG PET, but similar specificity.
Review
Medicine, General & Internal
Weijia Li, Dipan Uppal, Yu Chiang Wang, Xiaobo Xu, Damianos G. Kokkinidis, Mark I. Travin, James M. Tauras
Summary: Cardiac amyloidosis is a challenging disease to diagnose due to its heterogeneous manifestations. While endomyocardial biopsy is considered the gold standard for diagnosis, radionuclide cardiac imaging has become more commonly used for diagnosing ATTR amyloidosis. Further research in imaging protocols is needed to improve quantification of disease burden and prognosis prediction.
Article
Cardiac & Cardiovascular Systems
Mohamed Elwazir, Megan L. Krause, John P. Bois, Georgios Christopoulos, Ayse T. Kendi, Jr Leslie T. Cooper, Hayan Jouni, Omar F. Abouezzeddine, Panithaya Chareonthaitawee, Mohamed Abdelshafee, Shreyasee Amin
Summary: This study examined the effect of rituximab on cardiac inflammation and function in corticosteroid-refractory cardiac sarcoidosis. The results showed that rituximab can reduce inflammation and improve cardiac function in patients with active cardiac sarcoidosis. This suggests that rituximab may be a promising therapeutic option for this condition, which requires further study.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vassilis Koutoulidis, Evangelos Terpos, Nikolaos Papanikolaou, Sophia Fontara, Ioannis Seimenis, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Charis Bourgioti, Joao Santinha, Jose Maria Moreira, Efstathios Kastritis, Meletios A. Dimopoulos, Lia A. Moulopoulos
Summary: Early changes in bone marrow relative fat fraction (rFF) histogram metrics, calculated from MRI examination after one cycle of induction therapy, can help predict treatment response in patients with newly diagnosed multiple myeloma.
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Marijana Tadic, Cesare Cuspidi, Sahrai Saeed, Bogomir Milojevic, Isidora Grozdic Milojevic
Summary: Cardiac sarcoidosis is a systemic granulomatous disease that can lead to cardiac involvement, increased cardiovascular morbidity, and mortality. Echocardiography is the first choice imaging technique, while 18F-fluorodeoxyglucose positron emission tomography (PET) plays an essential role in diagnosis and monitoring. Validation of techniques like cardiac magnetic resonance (CMR) in large studies is necessary for accurate diagnosis and monitoring of patients with cardiac sarcoidosis.
HEART FAILURE REVIEWS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Sanjay Divakaran, Michael T. Osborne
Summary: Cardiac F-18-FDG PET is an important tool for diagnosing and managing inflammatory cardiovascular pathologies, including cardiac sarcoidosis. Sarcoidosis can affect the heart and impair cardiac function.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Chaitanya Rojulpote, Abhijit Bhattaru, Christopher Jean, Sarah L. Adams, Vandan Patel, Mahesh K. Vidula, Senthil Selvaraj, Jacob Dubroff, Eliot Peyster, Caitlin B. Clancy, Karen Patterson, Francis E. Marchlinski, Milton Rossman, Lee Goldberg, Paco E. Bravo
Summary: This study investigated the effect of immunosuppressive therapy and biopsy status on myocardial FDG-PET/CT in assessing treatment response in patients with suspected cardiac sarcoidosis. The results showed that a favorable treatment response was more common when using moderate-to-high intensity prednisone dose, and individuals with biopsy-proven sarcoidosis and preserved systolic function were less likely to experience adverse outcomes during follow-up.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Chemistry, Organic
Aaron Schuell, Lisa Grothe, Eduardo Rodrigo, Thomas Erhard, Siegfried R. Waldvogel
Summary: A novel electrosynthetic approach for the synthesis of aryl dibenzothiophenium salts, including the metal-free, electrochemical formation of a C-S bond under ambient conditions, has been reported. The broad applicability of this method has been demonstrated with 14 examples, achieving isolated yields of up to 72%, including nitrogen-containing heterocycles. The resulting sulfonium salts can serve as precursors for the synthesis of [F-18]fluoroarenes found in PET tracer ligands.