Article
Medicine, Research & Experimental
Christine U. Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K. Vladar, Christina Sul, Eric P. Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S. Nozik, Rubin M. Tuder, Holger K. Eltzschig
Summary: Acute lung injury (ALI) is closely related to uncontrolled alveolar inflammation, and specific enzyme PFKFB3 of glycolytic pathway can regulate alveolar inflammation. Inhibition or deletion of Pfkfb3 in alveolar epithelia results in aggravated ALI. Further studies show the link between PFKFB3 and Hif1a, and pyruvate can treat ALI. Human lung biopsy results also support the role of PFKFB3 in injured lungs.
Article
Immunology
Yafei Yuan, Wei Wang, Yue Zhang, Qiaohui Hong, Wenhui Huang, Lijuan Li, Zhanzhan Xie, Yixin Chen, Xu Li, Ying Meng
Summary: Apelin-13 protects against LPS-induced inflammatory responses and ALI by regulating PFKFB3-driven glycolysis induced by NOX4-dependent ROS.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Qiuhua Yang, Emily Huo, Yongfeng Cai, Zhidan Zhang, Charles Dong, John M. Asara, Huidong Shi, Qingqing Wei
Summary: Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. In this study, the researchers found that glycolytic pathway genes are upregulated in renal myeloid cells during kidney fibrosis. By inhibiting the glycolytic activator Pfkfb3, they observed reduced fibrosis, decreased macrophage infiltration, and alterations in macrophage subtypes and phenotypes. Mechanistically, they found that glycolytic metabolites stabilize HIF1α, leading to changes in macrophage phenotypes that contribute to renal fibrosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jiean Xu, Lina Wang, Qiuhua Yang, Qian Ma, Yaqi Zhou, Yongfeng Cai, Xiaoxiao Mao, Qingen Da, Tammy Lu, Yunchao Su, Zsolt Bagi, Rudolf Lucas, Zhiping Liu, Mei Hong, Kunfu Ouyang, Yuqing Huo
Summary: The study reveals the critical role of Pfkfb3 in LPS-induced sepsis, showing that its knockout protects mice from severe effects and reduces inflammation by regulating the expression of inflammatory factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Dadong Liu, Min Xiao, Jing Zhou, Peng Wang, Jingwen Peng, Wenjian Mao, Yuepeng Hu, Yuxiu Liu, Jiangtao Yin, Lu Ke, Weiqin Li
Summary: CXCR4hi neutrophils, a subset of neutrophils with high CXCR4 expression, play an important role in sepsis-induced acute lung injury (ALI). PFKFB3, a key glycolysis gene, is upregulated in CXCR4hi neutrophils and promotes sepsis-induced ALI by enhancing neutrophil extracellular trap (NET) formation. PFKFB3-mediated glycolytic metabolism is involved in the regulation of NET formation in CXCR4hi neutrophils.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Quan He, Jun Yin, Baisong Zou, Hui Guo
Summary: The study found that WIN alleviates sepsis-related ALI by inhibiting macrophage glycolysis through the miR-29b-3p/FOXO3/PFKFB3 axis. These findings provide new therapeutic targets for alleviating sepsis-related ALI.
MOLECULAR IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Na Du, Huimin Lin, Anqi Zhang, Chun Cao, Xiaojie Hu, Jin Zhang, Lili Wang, Xuesheng Pan, Yueqin Zhu, Fangyi Qian, Yuanyuan Wang, Dahai Zhao, Mingming Liu, Yan Huang
Summary: The protective effects of N5P against LPS-induced ALI were demonstrated in this study, potentially through the modulation of the HIF-1 alpha/glycolysis/ASIC1a signaling pathway to reduce inflammation levels.
Review
Medicine, General & Internal
Min Xiao, Dadong Liu, Yao Xu, Wenjian Mao, Weiqin Li
Summary: Sepsis is the leading cause of infection-related death, and metabolic disorder, particularly intensified glycolysis, plays a vital role in the progression of sepsis. The enzyme PFKFB3 controls the rate of glycolysis and has been found to be accelerated by sepsis in various cells, leading to excessive inflammation and mortality. Inhibiting PFKFB3 alone or in combination shows promising potential for sepsis treatment. This review summarizes the role of PFKFB3-driven glycolysis in immunocyte activation and nonimmune cell damage in sepsis, as well as recent advancements in PFKFB3 drugs and their therapeutic application in sepsis.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Qianhui Dou, Aaron K. Grant, Cody Callahan, Patricia Coutinho de Souza, David Mwin, Adam L. Booth, Imad Nasser, Marwan Moussa, Muneeb Ahmed, Leo L. Tsai
Summary: This study investigated the glycolytic regulation factors in hepatocellular carcinoma (HCC) and explored their potential therapeutic targets. The results showed that inhibiting PFKFB3 can prevent glycolytic-mediated HCC proliferation, which can be monitored by in vivo h13C MRI.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cell Biology
Zi-Yi Zhou, Lin Wang, Yu-Sheng Wang, Guo-Rui Dou
Summary: The current treatment for ocular pathological angiogenesis focuses on anti-VEGF signals, but regulation of endothelial glycolysis has emerged as a potential treatment targeting vessel sprouting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yan Zhang, Ding Yuan, Yi Li, Fang Yang, Linlin Hou, Yanwu Yu, Changhua Sun, Guoyu Duan, Cuicui Meng, Hongyi Yan, Dongxu Li, Yanxia Gao, Tongwen Sun, Changju Zhu
Summary: The study found that paraquat regulates the polarization of alveolar macrophages through glycolysis, promoting acute lung injury in rats. In vivo, lung pathological damage in rats gradually increased after paraquat poisoning, and the toxic effect on alveolar macrophages was dose- and time-dependent.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Yiyan Songyang, Wen Li, Wenqiang Li, Ji Yang, TianBao Song
Summary: This study found that phloretin (PHL), an apple polyphenol, can prevent lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting glycolysis in macrophages, and its action depends on the inhibition of glucose transporter 1 (GLUT1).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuai Guo, Anqi Li, Xiaodong Fu, Zou Li, Kaixiang Cao, Mingchuan Song, Shuqi Huang, Ziling Li, Jingwei Yan, Litao Wang, Xiaoyan Dai, Du Feng, Yong Wang, Jun He, Yuqing Huo, Yiming Xu
Summary: PFKFB3 plays a dual role in the pathogenesis of atherosclerosis. It controls the proliferation and infiltration of proinflammatory monocytes, and its expression is associated with expansion of inflammatory monocytes in patients with atherosclerotic coronary artery disease. However, homozygous loss of Pfkfb3 impairs macrophage efferocytosis and exacerbates atherosclerosis in Apoe(-/-) mice.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Weimou Chen, Jinming Zhang, Wenshan Zhong, Yuanyuan Liu, Ye Lu, Zhaojin Zeng, Haohua Huang, Xuan Wan, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Don
Summary: Our study demonstrates that anlotinib has antifibrotic effects by inhibiting myofibroblast activation and glycolysis. We also reveal a novel mechanism involving PCBP3 in regulating glycolysis reprogramming during lung fibrogenesis, suggesting it as a potential therapeutic target for pulmonary fibrosis. Anlotinib shows promise as a potent candidate for treating pulmonary fibrosis due to its preventative and therapeutic effects observed in animal models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Reem Aboushousha, Evan Elko, Shi B. Chia, Allison M. Manuel, Cheryl van de Wetering, Jos van der Velden, Maximilian MacPherson, Cuixia Erickson, Julie A. Reisz, Angelo D'Alessandro, Emiel F. M. Wouters, Niki L. Reynaert, Ying-Wai Lam, Vikas Anathy, Albert van der Vliet, David J. Seward, Yvonne M. W. Janssen-Heininger
Summary: The study reveals that IL1B induces glycolysis in airway epithelial cells, potentially affecting allergic airway inflammation and remodeling. Cells lacking the enzyme Glrx show modulation of multiple metabolic pathways and increased secretion of TSLP. Targeted inhibition of glycolysis prevents TSLP release, suggesting a potential therapeutic target in pulmonary pathologies.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)