The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea

Rosacea: New Concepts in Classification and Treatment

(2021) Esther J. van Zuuren et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

ANTIMICROBIAL PEPTIDE LL-37 DRIVES ROSACEA-LIKE SKIN INFLAMMATION IN AN NLRP3-DEPENDENT MANNER

(2021) Sung-Hyun Yoon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Itch: epidemiology, clinical presentation, and diagnostic workup

(2021) Youkyung S. Roh et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Itch: Pathogenesis and treatment

(2021) Nishadh Sutaria et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Metformin strengthens uroepithelial immunity against E. coli infection

(2021) Rakesh Kumar Majhi et al.   Scientific Reports

TRPV4 activation by thermal and mechanical stimuli in disease progression

(2020) Koji Shibasaki   LABORATORY INVESTIGATION

Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors

(2020) Devin M. Barry et al.   Nature Communications

Analysis of Mrgprb2 Receptor-Evoked Ca2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice

(2020) Volodymyr Tsvilovskyy et al.   Frontiers in Immunology

New and emerging treatments for inflammatory itch

(2020) Stephen Erickson et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Recommendations for rosacea diagnosis, classification and management: Update from the global ROSacea COnsensus (ROSCO) 2019 panel

(2019) M. Schaller et al.   BRITISH JOURNAL OF DERMATOLOGY

The Neuropeptide Y Y2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y2 Activation Reduces Histaminergic and IL-31-Induced Itch

(2019) Haisha Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Physiology and Pathophysiology of Itch

(2019) Ferda Cevikbas et al.   PHYSIOLOGICAL REVIEWS

Cytokine modulation of atopic itch

(2018) Anna M Trier et al.   CURRENT OPINION IN IMMUNOLOGY

Rosacea Pathogenesis

(2018) Christine S. Ahn et al.   DERMATOLOGIC CLINICS

Psychosocial Burden and Other Impacts of Rosacea on Patients’ Quality of Life

(2018) Elias Oussedik et al.   DERMATOLOGIC CLINICS

Tryptase as a polyfunctional component of mast cells

(2018) Dmitri Atiakshin et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Transient receptor potential vanilloid 4–expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch

(2018) Jialie Luo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The vicious cycle of itch and anxiety

(2018) Kristen M. Sanders et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Skin neurogenic inflammation

(2018) Jae Eun Choi et al.   Seminars in Immunopathology

Global Epidemiology and Clinical Spectrum of Rosacea, Highlighting Skin of Color: Review and Clinical Practice Experience

(2018) Andrew F. Alexis et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis

(2018) Yangfan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens

(2017) Vemuri B. Reddy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TRPV4 Mediates Mast Cell Activation in Cathelicidin-Induced Rosacea Inflammation

(2017) Nicholas L. Mascarenhas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of Pain and Itch by TRP Channels

(2017) Carlene Moore et al.   Neuroscience Bulletin

Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch

(2016) Yong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurocutaneous disease

(2016) Miguel Chuquilin et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells

(2016) Audrey Gambade et al.   Oncotarget

Cathelicidin LL-37 Induces Semaphorin 3A Expression in Human Epidermal Keratinocytes: Implications for Possible Application to Pruritus

(2015) Yoshie Umehara et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner

(2015) Gabriel Bidaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast Cells Are Key Mediators of Cathelicidin-Initiated Skin Inflammation in Rosacea

(2014) Yumiko Muto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Camphor Activates and Sensitizes Transient Receptor Potential Melastatin 8 (TRPM8) to Cooling and Icilin

(2013) Tudor Selescu et al.   CHEMICAL SENSES

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

(2013) David P Roberson et al.   NATURE NEUROSCIENCE

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Distribution and Expression of Non-Neuronal Transient Receptor Potential (TRPV) Ion Channels in Rosacea

(2011) Mathias Sulk et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rosacea: the Cytokine and Chemokine Network

(2011) Peter Arne Gerber et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Neurovascular and Neuroimmune Aspects in the Pathophysiology of Rosacea

(2011) Verena D. Schwab et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Antimicrobial Peptides Human  -Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

(2010) F. Niyonsaba et al.   JOURNAL OF IMMUNOLOGY

Behavioral differentiation between itch and pain in mouse

(2008) Steven G. Shimada et al.   PAIN