New paradigms in clonal evolution: punctuated equilibrium in cancer

Osimertinib: First Global Approval

(2016) Sarah L. Greig   DRUGS

Genomic Copy Number Alterations in Renal Cell Carcinoma with Sarcomatoid Features

(2016) Timothy Ito et al.   JOURNAL OF UROLOGY

Identification of neutral tumor evolution across cancer types

(2016) Marc J Williams et al.   NATURE GENETICS

Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer

(2016) Pedro M. Enriquez-Navas et al.   Science Translational Medicine

Adjuvant and Neoadjuvant Therapy for Pancreatic Cancer

(2016) Daneng Li et al.   Surgical Oncology Clinics of North America

Low-Grade Dysplasia in Ulcerative Colitis: Risk Factors for Developing High-Grade Dysplasia or Colorectal Cancer

(2015) Chang-ho Ryan Choi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mechanisms of Cancer Cell Dormancy--Another Hallmark of Cancer?

(2015) A. C. Yeh et al.   CANCER RESEARCH

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity

(2015) T.-M. Kim et al.   CLINICAL CANCER RESEARCH

Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus

(2015) Danielle L Lavery et al.   GUT

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

Using tumour phylogenetics to identify the roots of metastasis in humans

(2015) Kamila Naxerova et al.   Nature Reviews Clinical Oncology

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

(2015) Shaoping Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis

(2015) Bhadravathi Marigowda Shivakumar   WORLD JOURNAL OF GASTROENTEROLOGY

Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

(2015) N. Murugaesu et al.   Cancer Discovery

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma

(2015) Tae-Min Kim et al.   Oncotarget

Cancer: Evolution Within a Lifetime

(2014) Marco Gerlinger et al.   Annual Review of Genetics

Coelacanths

(2014) Mark Robinson et al.   CURRENT BIOLOGY

Replicative DNA polymerase mutations in cancer

(2014) Ellen Heitzer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

(2014) Yong Wang et al.   NATURE

Technology: The $1,000 genome

(2014) Erika Check Hayden   NATURE

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Barrett oesophagus: lessons on its origins from the lesion itself

(2014) Stuart A. C. McDonald et al.   Nature Reviews Gastroenterology & Hepatology

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

(2014) J. Zhang et al.   SCIENCE

Cancer Evolution: Mathematical Models and Computational Inference

(2014) Niko Beerenwinkel et al.   SYSTEMATIC BIOLOGY

Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer

(2014) Jung Ho Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

(2014) Niccolo Bolli et al.   Nature Communications

Tumor Evolution in Response to Chemotherapy: Phenotype versus Genotype

(2014) Nicholas E. Navin   Cell Reports

Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes

(2014) Sheli L. Ostrow et al.   PLoS Genetics

Methods and challenges in timing chromosomal abnormalities within cancer samples

(2013) Elizabeth Purdom et al.   BIOINFORMATICS

Punctuated Evolution of Prostate Cancer Genomes

(2013) Sylvan C. Baca et al.   CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting ecological principles to better understand cancer progression and treatment

(2013) D. Basanta et al.   Interface Focus

Chromothripsis and Human Disease: Piecing Together the Shattering Process

(2012) Christopher A. Maher et al.   CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Adenoma detection rate increases with each decade of life after 50 years of age

(2011) Sarah J. Diamond et al.   GASTROINTESTINAL ENDOSCOPY

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

(2011) Frederik Hvid-Jensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Temporal Dissection of Tumorigenesis in Primary Cancers

(2011) Steffen Durinck et al.   Cancer Discovery

Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer

(2010) S L Cooke et al.   BRITISH JOURNAL OF CANCER

Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas

(2010) Christina Thirlwell et al.   GASTROENTEROLOGY

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

(2010) So Yeon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

A change of strategy in the war on cancer

(2009) Robert A. Gatenby   NATURE