Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma

Dupilumab improves clinical outcomes in patients with asthma and perennial allergic rhinitis

(2020) William W. Busse et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Tumor-localized costimulatory T cell engagement by the 4-1BB/HER2 bispecific antibody-Anticalin fusion PRS-343

(2019) Marlon J Hinner et al.   CLINICAL CANCER RESEARCH

Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey

(2018) Andreas M Hohlbaum et al.   BRITISH JOURNAL OF PHARMACOLOGY

Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain–Fused Anticalin Protein

(2018) Yusuke Masuda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro

(2017) Kinga Balogh Sivars et al.   TOXICOLOGICAL SCIENCES

Functional characterization of a VEGF-A-targeting Anticalin, prototype of a novel therapeutic human protein class

(2015) Hendrik Gille et al.   ANGIOGENESIS

Targeting key proximal drivers of type 2 inflammation in disease

(2015) Namita A. Gandhi et al.   NATURE REVIEWS DRUG DISCOVERY

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

(2015) Norbert Krug et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs

(2013) Agnieszka Turowska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Growth and characterization of different human rhinovirus C types in three-dimensional human airway epithelia reconstituted in vitro

(2013) Caroline Tapparel et al.   VIROLOGY

Combinatorial Design of an Anticalin Directed against the Extra-Domain B for the Specific Targeting of Oncofetal Fibronectin

(2012) Michaela Gebauer et al.   JOURNAL OF MOLECULAR BIOLOGY

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthma

(2009) A. Tomkinson et al.   ALLERGY

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2

(2009) Hyun Jin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies

(2009) D. Schonfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative binding proteins: Anticalins - harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities

(2008) Arne Skerra   FEBS Journal

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET