Article
Clinical Neurology
Yajing Pang, Qiang Wei, Shanshan Zhao, Nan Li, Zhihui Li, Fengmei Lu, Jianyue Pang, Rui Zhang, Kai Wang, Congying Chu, Yanghua Tian, Jiaojian Wang
Summary: This study investigates the longitudinal effects of electroconvulsive therapy (ECT) on resting-state functional connectivity (FC) in patients with major depressive disorder (MDD). The findings suggest that the changes in FC within the default mode network (DMN) and between DMN and central executive network (CEN) may be critical for effective antidepressant treatment and can also serve as neuromarkers for predicting treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Ida Ronnqvist, Fredrik K. Nilsson, Axel Nordenskjold
Summary: This Swedish cohort study found that patients with severe depression who received ECT had a lower risk of suicide compared to those who did not receive ECT during inpatient care. Especially for hospitalized patients older than 45 years and with a psychotic subtype, the use of ECT was associated with a reduced risk of suicide.
Article
Clinical Neurology
Linda Steinholtz, Johan Reutfors, Lena Brandt, Pia Nordanskog, Elin Thornblom, Jonas Persson, Robert Boden
Summary: Response rates to electroconvulsive therapy in depression may be lower in patients with concurrent personality or anxiety disorders, but the majority of patients still respond positively. The impact of comorbidity decreases with higher age and severity of depressive episode; subjective ratings of memory impairment do not differ between patients with and without comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yumeng Xin, Tongjian Bai, Ting Zhang, Yang Chen, Kai Wang, Shan Yu, Ning Liu, Yanghua Tian
Summary: The study found that compared to healthy controls, MDD patients have certain changes in criticality, but patients who respond positively to ECT often correct these anomalies. Importantly, ECT can modulate the large-scale brain dynamics of MDD patients to be closer to criticality.
Article
Clinical Neurology
Liang Su, Yi Zhang, Yuping Jia, Junfeng Sun, David Mellor, Ti-Fei Yuan, Yifeng Xu
Summary: This study investigated the response trajectories of MDD patients undergoing ECT treatment and identified potential clinical and demographic predictors for clinical improvement. The results revealed three groups of patients: non-remit, slow-response, and rapid-response. Significant differences in various factors such as age, education years, and baseline depression severity were observed across these groups. These clinical predictors can help guide treatment selection.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Dominique S. Scheepens, Jeroen A. van Waarde, Freek ten Doesschate, Mirjam Westra, Marijn C. W. Kroes, Aart H. Schene, Robert A. Schoevers, Damiaan Denys, Henricus G. Ruhe, Guido A. van Wingen
Summary: This study examines the effects of electroconvulsive therapy (ECT) on negative schemas and depressive symptoms in patients with treatment-resistant major depressive disorder (MDD). The results suggest that ECT can improve negative schemas, which in turn mediates the improvement of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yue Wu, Yang Ji, Tongjian Bai, Qiang Wei, Meidan Zu, Yuanyuan Guo, Huaming Lv, Aiguo Zhang, Bensheng Qiu, Kai Wang, Yanghua Tian
Summary: This study investigated the effects of electroconvulsive therapy (ECT) on brain networks in major depressive disorder (MDD) patients. The results showed that ECT improved the nodal degree of specific brain regions, such as the angular cortex and precuneus. Furthermore, the increased nodal degree was found to be associated with decreased depressive symptoms. These findings provide insights into the mechanism of depression treatment and potential targets for antidepressant pharmacotherapies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
M. van Verseveld, R. J. T. Mocking, D. Scheepens, F. ten Doesschate, M. Westra, R. A. Schoevers, A. H. Schene, G. A. van Wingen, J. A. van Waarde, H. G. Ruhe
Summary: This study provides the first indication that polyunsaturated fatty acids (PUFAs) are associated with the efficacy of electroconvulsive therapy (ECT). The results suggest that PUFAs may affect ECT outcomes by influencing neuronal electrochemical properties and neurogenesis. PUFAs could potentially serve as a modifiable factor predicting ECT outcomes and further investigation is warranted in other ECT cohorts.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Clinical Neurology
Debora de A. Simoes Moreira, Luis Eduardo Gauer, Guilherme Teixeira, Amanda Carolina Fonseca da Silva, Stefanie Cavalcanti, Joao Quevedo
Summary: This study compared the efficacy and tolerability of electroconvulsive therapy (ECT) and ketamine for different depression outcomes. The results showed no significant difference between ketamine and ECT in reducing the severity of depressive symptoms and response to therapy. However, there was a significant decrease in the risk of muscle pain with ketamine compared to ECT during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychology, Clinical
Anil K. Bachu, Vijaya Padma Kotapati, Tejasvi Kainth, Rikinkumar Patel, Nagy A. Youssef, Rajesh R. Tampi
Summary: This study systematically reviewed the literature on the use of electroconvulsive therapy (ECT) in patients with dementia/major NCD presenting with behavioral symptoms. The results showed that ECT can effectively alleviate behavioral symptoms in these patients, but sometimes adverse events may occur.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Caitlin C. Clements, Robert Karlsson, Yi Lu, Anders Jureus, Christian Ruck, Evelyn Andersson, Julia Boberg, Nancy L. Pedersen, Cynthia M. Bulik, Axel Nordenskjold, Erik Palsson, Patrick F. Sullivan, Mikael Landen
Summary: Analysis of severe cases of major depressive disorder (MDD) using genome-wide SNP genotyping revealed a higher burden of genetic risk loci, stronger genetic correlations with other psychiatric disorders, and weaker correlations with personality and stress-related traits, suggesting a different genetic architecture at the severe end of the MDD spectrum.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
J. J. E. Rovers, P. Vissers, D. Loef, J. A. van Waarde, J. P. A. J. Verdijk, B. F. P. Broekman, A. C. M. Vergouwen, M. L. Oudega, E. van Exel, R. Coenen, D. S. Everaerd, I. Tendolkar, A. Dols, P. F. P. van Eijndhoven
Summary: This study investigates the association between treatment resistance and the outcome and course of electroconvulsive therapy (ECT) in major depressive disorder (MDD). The results showed that higher levels of treatment resistance were associated with smaller reductions in depression symptoms and lower chances of response. Furthermore, patients with lower treatment resistance required fewer ECT sessions and had fewer switches to bilaterally electrode placement, potentially reducing the risk of cognitive side effects.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Fangyue Chen, Emad Sidhom, Sharon Yang, Eladia Ruiz-Mendoza, Julius Essem
Summary: This is a case report of a 75-year-old female patient with severe depression who did not respond to ECT until the 11th session. She showed significant improvement after a total of 17 ECT sessions and remained well 3 months post-treatment. The case highlights the importance of considering individual response variability in ECT treatment and the potential need for further research to standardize treatment guidelines.
Article
Clinical Neurology
Santiago Madero, Gerard Anmella, Maria Sague-Vilavella, Maria Teresa Pons, Anna Gimenez, Andrea Murru, Marta Gomez-Ramiro, Joaquin Gil-Badenes, Jose Rios, Miquel Bioque, Eduard Vieta, Antonio Benabarre
Summary: This study aimed to investigate the real-life effectiveness of maintenance electroconvulsive therapy(mECT) in bipolar disorder(BD). The results showed that mECT can effectively reduce the number and duration of psychiatric hospitalizations in BD patients, supporting its effectiveness in the treatment of BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Santiago Madero, Gerard Anmella, Maria Sague-Vilavella, Maria Teresa Pons, Anna Gimenez, Andrea Murru, Marta Gomez-Ramiro, Joaquin Gil-Badenes, Jose Rios, Miquel Bioque, Eduard Vieta, Antonio Benabarre
Summary: This study aimed to investigate the effectiveness of maintenance electroconvulsive therapy (mECT) in treating bipolar disorder (BD). The results showed that mECT had a 62.2% effectiveness in preventing psychiatric hospitalizations and significantly reduced the number of hospitalization days and admissions for BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Melissa G. Guineau, N. Ikani, M. Rinck, R. M. Collard, P. van Eijndhoven, I Tendolkar, A. H. Schene, E. S. Becker, J. N. Vrijsen
Summary: This study found that anhedonia severity and depression symptom severity play a central role in the network. The results suggest that anhedonia severity may predict the severity of symptom clusters in MDD, AS, ADHD, and ASD. Additionally, the severity of MDD symptoms may predict the severity of AS and ADHD symptoms. These findings indicate that anhedonia may serve as a common underlying psychopathology feature, predictive of symptom severity in depression, AS, ADHD, and ASD. Therefore, clinicians should be vigilant in screening for anhedonia and depression severity in individuals with anxiety disorders, ADHD, and/or ASD.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Rehabilitation
Adeline Julien, Lola Danet, Mallaury Loisel, David Brauge, Jeremie Pariente, Patrice Peran, Melanie Planton
Summary: The objective of this study was to identify, categorize, and analyze the methodological issues of cognitive rehabilitation in patients with moderate to severe traumatic brain injury and its efficacy. A total of 46 articles on cognitive rehabilitation for adults with traumatic brain injury were included in the study, which showed a wide range of cognitive domains targeted by interventions. Individual sessions were the most common delivery method, accounting for 83%, and an integrative cognitive approach was used in 48% of the studies. Neuroimaging tools as outcome measures were used in only 20% of the studies. Overall, 43 studies reported significant effects of cognitive rehabilitation, and 7 of them had a high level of methodological evidence.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Behavioral Sciences
Simon Hjerrild, Martin Balslev Jorgensen, Ole Henrik Dam, Elisabeth Tehrani, Poul Videbech, Merete Osler
Summary: The aim of this study is to investigate the association between electroconvulsive therapy (ECT) and the subsequent risk of road traffic accidents. A cohort of 375,435 patients with their first psychiatric hospital contact between 2003 and 2017 in Denmark was followed up until December 2018. The analysis showed that ECT was not associated with an increased risk of road traffic accidents.
Article
Behavioral Sciences
Federico Nemmi, Fabien Cignetti, Marianne Vaugoyeau, Christine Assaiante, Yves Chaix, Patrice Peran
Summary: Developmental dyslexia (DD) and developmental coordination disorder (DCD) are two common neurodevelopmental disorders that may share similar neural underpinnings. This study used structural and resting-state functional MRI images to compare TD children, children with DD, DCD, and those with both disorders (COM). Machine learning models were trained using brain structural and functional indexes to discriminate among the three groups. The most discriminant regions were found in the cerebellum for DCD and the temporal lobe for DD. The study also revealed subtle brain differences in children with both DD and DCD that can only be captured using multiple imaging indexes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marie Beaurain, Franck Talmont, Damien Pierre, Patrice Peran, Samuel Boucher, Anne Hitzel, Marie-Pierre Rols, Olivier Cuvillier, Pierre Payoux, Salabert Anne-Sophie
Summary: Dysfunction of NMDA receptors is central to the pathophysiology of psychiatric and neurodegenerative disorders, but its mechanisms are not well understood. This study describes the development of a PET tracer that can selectively bind to the NMDA receptors and visualize them in an open and active state. It also demonstrates the tracer's ability to detect activated NMDA receptors in a rat model of excitotoxicity.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Psychology, Clinical
Clemens Mielacher, Dirk Scheele, Maximilian Kiebs, Laura Schmitt, Torge Dellert, Alexandra Philipsen, Claus Lamm, Rene Hurlemann
Summary: This study found that there are altered neural responses to social touch in patients with major depressive disorder (MDD). Despite clinical improvements after antidepressant treatment, MDD patients still showed aversion to interpersonal touch and reduced brain responses in areas such as the nucleus accumbens compared to healthy controls. These findings reveal the abnormal processing of social touch in MDD, which may contribute to social withdrawal and isolation.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Fatima Tensaouti, Franck Desmoulin, Julia Gilhodes, Margaux Roques, Soleakhena Ken, Jean -Albert Lotterie, Georges Noel, Gilles Truc, Marie -Pierre Sunyach, Marie Charissoux, Nicolas Magne, Vincent Lubrano, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: This study aimed to identify different components of glioblastoma subtypes using a large MRSI dataset and determine their association with progression-free survival. The results showed that pre-radiotherapy MRSI can reveal tumor heterogeneity and clusters with metabolic abnormalities and high lactate are predictive of PFS.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Clinical Neurology
Freek ten Doesschate, Willem Bruin, Peter Zeidman, Christopher C. Abbott, Miklos Argyelan, Annemieke Dols, Louise Emsell, Philip F. P. van Eijndhoven, Eric van Exel, Peter C. R. Mulders, Katherine Narr, Indira Tendolkar, Didi Rhebergen, Pascal Sienaert, Mathieu Vandenbulcke, Joey Verdijk, Mike van Verseveld, Hauke Bartsch, Leif Oltedal, Jeroen A. van Waarde, Guido A. van Wingen
Summary: A recent multi-center study found no consistent changes in correlation-based resting-state connectivity after ECT, but effective connectivity may provide more insight into the working mechanism of ECT.
Article
Clinical Neurology
Ana Marques, Elise Macias, Bruno Pereira, Elodie Durand, Carine Chassain, Tiphaine Vidal, Luc Defebvre, Nicolas Carriere, Valerie Fraix, Elena Moro, Stephane Thobois, Elise Metereau, Graziella Mangone, Marie Vidailhet, Jean-Christophe Corvol, Stephane Lehericy, Nicolas Menjot de Champfleur, Christian Geny, Umberto Spampinato, Wassilios G. Meissner, Solene Frismand, Emmanuelle Schmitt, Anne Doe de Maindreville, Christophe Portefaix, Philippe Remy, Gilles Fenelon, Jean Luc Houeto, Olivier Colin, Olivier Rascol, Patrice Peran, Jean-Marie Bonny, Maria Livia Fantini, Franck Durif
Summary: This study evaluated brain volumetric changes in PD patients using MRI and found that baseline brain volumetric characteristics may predict clinical trajectories at 1 year. Specifically, posterior cingulate cortex atrophy was associated with motor decline, while amygdala and hippocampus atrophy were associated with psycho-behavioral decline.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Margot G. A. Van Cauwenberge, Aline Delva, Thomas Vande Casteele, Maarten Laroy, Ahmed Radwan, Kristof Vansteelandt, Jan Van den Stock, Filip Bouckaert, Koen Van Laere, Louise Emsell, Wim Vandenberghe, Mathieu Vandenbulcke
Summary: This study aimed to investigate the correlation between mild motor signs (MMS) in old age and synaptic density in the brain. The results showed that MMS in healthy aging are associated with lower synaptic density throughout the brain.
MOVEMENT DISORDERS
(2023)
Article
Psychology, Clinical
Lies Van Assche, Akihiro Takamiya, Jan van den Stock, Luc van de Ven, Patrick Luyten, Louise Emsell, Mathieu Vandenbulcke
Summary: Very-late-onset schizophrenia-like psychosis (VLOSLP) is a psychiatric disorder associated with lower grey matter volume (GMV) in the thalamus, left inferior frontal gyrus, and left insula. Lower thalamic GMV is correlated with memory impairment in this disorder. The findings provide important clues for understanding the neurobiology of VLOSLP.
PSYCHOLOGICAL MEDICINE
(2023)
Meeting Abstract
Geriatrics & Gerontology
Maarten Pieter Rozing, Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Terese Sara Hoj Jorgensen, Martin Balslev Jorgensen, Merete Osler
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Psychiatry
Terese Sara Hoj Jorgensen, Merete Osler, Martin Balslev Jorgensen, Anders Jorgensen
Summary: The objective of this study was to establish a comprehensive map of subsequent diagnoses after a first psychiatric hospital diagnosis. Through the Danish National Patient Registry, patients aged 18 years or older with an inpatient or outpatient psychiatric hospital contact were identified. Over 10 years of follow-up, 46.9% of the patients had at least one subsequent diagnosis that differed from their first-time diagnosis.
Article
Biochemistry & Molecular Biology
Miklos Argyelan, Zhi-De Deng, Olga Therese Ousdal, Leif Oltedal, Brian Angulo, Mate Baradits, Andrew J. Spitzberg, Ute Kessler, Alexander Sartorius, Annemiek Dols, Katherine L. Narr, Randall Espinoza, Jeroen A. van Waarde, Indira Tendolkar, Philip van Eijndhoven, Guido A. van Wingen, Akihiro Takamiya, Taishiro Kishimoto, Martin B. Jorgensen, Anders Jorgensen, Olaf B. Paulson, Antoine Yrondi, Patrice Peran, Carles Soriano-Mas, Narcis Cardoner, Marta Cano, Linda van Diermen, Didier Schrijvers, Jean-Baptiste Belge, Louise Emsell, Filip Bouckaert, Mathieu Vandenbulcke, Maximilian Kiebs, Rene Hurlemann, Peter C. R. Mulders, Ronny Redlich, Udo Dannlowski, Kavakbasi Erhan, Michael D. Kritzer, Kristen K. Ellard, Joan A. Camprodon, Georgios Petrides, Anil K. Malhotra, Christopher C. Abbott
Summary: Neurostimulation is a common treatment option for major depression, and this study found that electroconvulsive therapy has similar neuronal underpinnings to a causal depression network. The expression of this pattern was correlated with clinical outcomes, suggesting that optimizing modulation of this network could improve the effectiveness of neurostimulation in depression.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)