Review
Cell Biology
Marco Proietti, Giulio Francesco Romiti, Valeria Raparelli, Igor Diemberger, Giuseppe Boriani, Laura Adelaide Dalla Vecchia, Giuseppe Bellelli, Emanuele Marzetti, Gregory Y. H. Lip, Matteo Cesari
Summary: This study systematically reviewed the prevalence of frailty in patients with atrial fibrillation (AF) and its association with major outcomes. The results showed a high prevalence of frailty in AF patients and its impact on prognosis and management.
AGEING RESEARCH REVIEWS
(2022)
Article
Geriatrics & Gerontology
Erwin Stolz, Emiel O. Hoogendijk, Hannes Mayerl, Wolfgang Freidl
Summary: Various studies have shown consistent associations between current FI levels, baseline FI levels, and mortality. Additionally, individuals with steeper FI growth have a higher risk of mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Marina Lleal, Celia Corral-Vazquez, Montserrat Bare, Ricard Comet, Susana Herranz, Francisco Baigorri, Antonio Gimeno-Miguel, Maria Raurich, Cristina Fortia, Marta Navarro, Beatriz Poblador-Plou, Marisa Bare
Summary: This study analyzed multimorbidity clusters in COVID-19 patients and found associations with infection severity/mortality, particularly in younger individuals. These findings contribute to a better understanding of the disease risk and severity in different populations, providing guidance for prevention and treatment in the community.
Article
Geriatrics & Gerontology
Thomas J. Wilkinson, Joanne Miksza, Francesco Zaccardi, Claire Lawson, Andrew C. Nixon, Hannah M. L. Young, Kamlesh Khunti, Alice C. Smith
Summary: Frailty is common in individuals with chronic kidney disease (CKD) and is associated with adverse outcomes, including mortality and risk of end-stage kidney disease (ESKD). Preventative interventions should be initiated to mitigate the development of frailty. The use of a simple frailty index, generated electronically from health records, can predict outcomes and may aid prioritization for management of people with frailty.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Geriatrics & Gerontology
Jennifer K. Burton, Jennifer Stewart, Mairi Blair, Sinead Oxley, Amy Wass, Martin Taylor-Rowan, Terence J. Quinn
Summary: Despite limited knowledge of frailty in stroke, studies show that frailty is common in patients with acute stroke and associated with poor outcomes.
Article
Cardiac & Cardiovascular Systems
William Shrauner, Emily M. Lord, Xuan-Mai T. Nguyen, Rebecca J. Song, Ashley Galloway, David R. Gagnon, Jane A. Driver, J. Michael Gaziano, Peter W. F. Wilson, Luc Djousse, Kelly Cho, Ariela R. Orkaby
Summary: Frailty is associated with an increased risk of cardiovascular (CV) mortality and events, independent of underlying CV disease. This study is the largest and most contemporary evaluation of the relationship between frailty and CV mortality to date.
EUROPEAN HEART JOURNAL
(2022)
Article
Clinical Neurology
Daehoon Kim, Pil-Sung Yang, Jung-Hoon Sung, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
Summary: In frail patients with atrial fibrillation, oral anticoagulant treatment is associated with positive clinical outcomes. Direct oral anticoagulants have lower incidences of stroke, bleeding, and mortality compared to warfarin.
Article
Cardiac & Cardiovascular Systems
Jessica Magid-Bernstein, Romuald Girard, Sean Polster, Abhinav Srinath, Sharbel Romanos, Issam A. Awad, Lauren H. Sansing
Summary: This review article provides an overview of the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of intracerebral hemorrhage (ICH). The incidence of hemorrhagic stroke has increased globally in the past 40 years, with changes in the cause over time due to improved hypertension management and increased use of anticoagulants. Preclinical and clinical trials have shed light on the underlying cause and mechanisms of injury from ICH, including the complex interaction between edema, inflammation, iron-induced injury, and oxidative stress. Although several trials have investigated the optimal medical and surgical management of ICH, there has been no clear improvement in survival and functional outcomes. Ongoing research into novel approaches for ICH management offers hope for reducing the devastating impact of this disease in the future.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Bengt Zoller, MirNabi Pirouzifard, Magnus P. Lindgren, Jan Sundquist, Kristina Sundquist
Summary: This study found that a family history of short sibling survival after IS is associated with mortality after IS for younger male subjects.
Article
Cardiac & Cardiovascular Systems
Bin Wang, Xueke Bai, Yang Yang, Jianlan Cui, Lijuan Song, Jiamin Liu, Jiapeng Lu, Jun Cai
Summary: Elevated blood pressure is highly prevalent among stroke survivors in China, regardless of age, sex, and region. It contributes significantly to cardiovascular mortality in stroke survivors, particularly in young and middle-aged patients. National strategies are needed to address the burden of stroke related to elevated blood pressure in China.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jarl Emanuel Strange, Daniel Molager Christensen, Caroline Sindet-Pedersen, Morten Schou, Alexander Christian Falkentoft, Lauge Ostergaard, Jawad Haider Butt, Peter Laursen Graversen, Lars Kober, Gunnar Gislason, Jonas Bjerring Olesen, Emil Loldrup Fosbol
Summary: Frailty is strongly associated with time in hospital and mortality among patients undergoing transcatheter aortic valve replacement. Higher frailty levels are linked to longer hospital stays and increased risk of death within one year. Strategies aimed at preventing hospitalization among frail patients could be beneficial in reducing the burden of care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Gerontology
Tessa Clemens, Amy E. Peden, Richard C. Franklin
Summary: The study reveals that unintentional fatal drowning rates among older adults aged 65 years and older vary in Australia, Canada, and New Zealand, and are increasing with the aging population. Different countries and age bands have significant locations and activities associated with older adult drowning.
JOURNAL OF AGING AND HEALTH
(2021)
Article
Geriatrics & Gerontology
Alexandra M. Wennberg, Marcus Ebeling, Stina Ek, Anna Meyer, Mozhu Ding, Mats Talbaeck, Karin Modig
Summary: Frailty prevalence increases with age and has become more common in recent birth cohorts. The relationship between frailty and mortality has not changed over time, and there is no difference in this relationship based on gender.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Nadia M. Chu, Karen Bandeen-Roche, Qian-Li Xue, Michelle C. Carlson, A. Richey Sharrett, Alden L. Gross
Summary: Frailty (PFP) and its criteria are associated with cognitive function in older adults, with frailty showing excess effects on cognitive performance beyond criteria contributions. Different criteria have varying effects on cognitive change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
Weijia Wang, Jane S. Saczynski, Darleen Lessard, Robert J. Goldberg, David Parish, Robert Helm, Catarina I. Kiefe, Katherine Trymbulak, Jordy Mehawej, Hawa Abu, Robert Hayward, Joel Gore, Jerry H. Gurwitz, David D. McManus
Summary: In older patients with atrial fibrillation (AF) taking anticoagulants, cognitive impairment and frailty are independently associated with major bleeding.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
J. Hancox, K. Ayling, L. Bedford, K. Vedhara, J. F. R. Roberston, B. Young, R. das Nair, F. M. Sullivan, S. Schembri, F. S. Mair, R. Littleford, D. Kendrick
Summary: The Early CDT(R)-Lung antibody blood test has positive effects in reducing late-stage lung cancer presentation, but it also leads to some negative psychological outcomes, although these effects are short-lived and small.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Anesthesiology
Claire E. Hastie, Hamish M. E. Foster, Bhautesh D. Jani, Catherine A. O'Donnell, Frederick K. Ho, Jill P. Pell, Naveed Sattar, Srinivasa V. Katikireddi, Frances S. Mair, Barbara I. Nicholl
Summary: We investigated the association between self-reported chronic pain and COVID-19 hospitalization or mortality. The study found that chronic pain was associated with higher risk of hospitalization for COVID-19, even after adjusting for other variables, with a clear dose-response relationship. However, the association with COVID-19 mortality was unclear.
Article
Rheumatology
Fraser R. Morton, Bhautesh Jani, Frances S. Mair, Philip McLoone, Jordan Canning, Sara Macdonald, Ross McQueenie, Stefan Siebert, Barbara Nicholl
Summary: This longitudinal observational study investigates the association between multimorbidity and hospitalizations in people with established and early rheumatoid arthritis (RA). Participants with RA and multiple long-term conditions (LTCs) had higher hospitalization rates and longer durations compared to those with RA alone. Additionally, the hospitalization rate and duration were higher in RA participants with LTCs than in non-RA controls.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Medicine, General & Internal
Elaine Butterly, Peter Hanlon, Anoop S. V. H. Shah, Laurie Hannigan, Emma S. McIntosh, Jim M. Lewsey, Sarah Wild, Bruce J. Guthrie, Frances A. Mair, David Kent, Sofia Dias, Nicky Welton, David McAllister
Summary: This study aimed to investigate the impact of multimorbidity on quality of life. The results showed that a higher comorbidity count was associated with lower baseline quality of life and a decline over time. However, treatment effects on quality of life were not modified by multimorbidity.
Review
Primary Health Care
Peter Hanlon, Xuetong Guo, Eveline McGhee, Jim Lewsey, David McAllister, Frances S. Mair
Summary: This systematic review examined the measurement, prevalence, and associations of frailty in individuals with COPD. A total of 53 eligible studies were included, using 11 different frailty measures. The prevalence of frailty varied depending on the definition and population. Frailty was found to be associated with adverse health outcomes, including mortality, exacerbations, hospitalization, airflow obstruction, dyspnea, COPD severity, lower quality of life, and disability. The proactive identification of frailty may help in risk stratification and targeted interventions for individuals with COPD.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Rosalind Adam, Revathi Nair, Lisa I. Duncan, Esyn Yeoh, Joanne Chan, Vaselisa Vilenskaya, Katie Gallacher
Summary: This systematic review investigated the perceptions of treatment burden in individuals living with and beyond cancer. The study found that treatment burden could be an important mediator of inequities in cancer outcomes. Clinicians should carefully consider their expectations and the resources required from patients, including the amount of patient time consumed.
Article
Medicine, General & Internal
Ann-Marie Towers, Adam Gordon, Arne Timon Wolters, Stephen Allan, Stacey Rand, Lucy Anne Webster, Elizabeth Crellin, Richard James Brine, Kaat De Corte, Gizdem Akdur, Lisa Irvine, Jennifer Burton, Barbara Hanratty, Anne Killett, Julienne Meyer, Liz Jones, Claire Goodman
Summary: This study aims to develop a minimum data set (MDS) to collect health and care data of care home residents in England, and link them with routine national health service and social care data. The study will explore the implementation and perceived utility of the MDS through qualitative and quantitative methods, and regular data collection and analysis.
Article
Geriatrics & Gerontology
Jane A. H. Masoli, Oliver Todd, Jennifer K. Burton, Christopher Wolff, Katherine E. Walesby, Jonathan Hewitt, Simon Conroy, James van Oppen, Chris Wilkinson, Ruth Evans, Atul Anand, Joe Hollinghurst, Cini Bhanu, Victoria L. Keevil, Emma R. L. C. Vardy, Geridata Grp
Summary: This commentary discusses the role of digital data in healthcare for the aging population and highlights the importance of proactive design of digital systems by healthcare professionals to cater to the needs of older adults, caregivers, and the workforce.
Article
Public, Environmental & Occupational Health
Nonzuzo Mbokazi, Myrna Van Pinxteren, Katherine Murphy, Frances S. Mair, Carl R. May, Naomi S. Levitt
Summary: In economically precarious areas of South Africa, Ubuntu, traditional values, and social networks play a crucial mediating role in helping people with HIV/NCD multimorbidity to self-manage their conditions. Despite facing economic hardship, patients actively cope with their workload by utilizing family relations and external networks, leading to better management of chronic diseases.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jennifer Kirsty Burton, Maria Drummond, Katie Gallacher, Terence J. Quinn
Summary: This study explores the experiences of care home staff in Scotland in managing COVID-19 outbreaks. The findings reveal diverse experiences of outbreaks within care homes, with tensions between staff experience and external regulation and oversight. Staff adapted to uncertainty but also faced psychological impacts. However, there was evidence of compassionate leadership and teamwork. The need for individualized support highlights the importance of respectful relationships and continuity.
Article
Medicine, General & Internal
Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee, Catherine A. O'Donnell
Summary: This study found that both functional and structural components of social connection are independently associated with mortality. It also suggests that the beneficial associations for some types of social connection might not be felt when other types of social connection are absent. Additionally, individuals who live alone with additional structural markers of isolation may represent a high-risk population.