Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke

Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism

(2022) Thorsten R. Doeppner et al.   Aging-US

Ischemic Stroke, Lessons from the Past towards Effective Preclinical Models

(2022) Beatriz Amado et al.   Biomedicines

Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD

(2022) Yoshitaka Tamaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation

(2021) Elena Spronk et al.   Frontiers in Neurology

Ultra-Short Duration Hypothermia Prevents Intracranial Pressure Elevation Following Ischaemic Stroke in Rats

(2021) Daniel Omileke et al.   Frontiers in Neurology

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis

(2021) Yuting Ren et al.   Frontiers in Neurology

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

(2020) Madalina Filfan et al.   GeroScience

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

(2019) Peng Wang et al.   PLoS Genetics

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

(2018) Inhae Kang et al.   FEBS LETTERS

Cerebral Ischemic Reperfusion Injury Following Recanalization of Large Vessel Occlusions

(2017) Fawaz Al-Mufti et al.   NEUROSURGERY

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats

(2017) Meiling Wu et al.   Annals of Clinical and Translational Neurology

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

(2016) Cassie M. Tran et al.   DIABETES

Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial

(2016) Serge Bracard et al.   LANCET NEUROLOGY

Aspiration Thrombectomy After Intravenous Alteplase Versus Intravenous Alteplase Alone

(2016) J Mocco et al.   STROKE

Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia–ischemia

(2015) Makiko Ohshima et al.   BRAIN & DEVELOPMENT

Ischaemic conditioning strategies reduce ischaemia/reperfusion-induced organ injury

(2015) C.K. Pac-Soo et al.   BRITISH JOURNAL OF ANAESTHESIA

Recent advances in autophagy-based neuroprotection

(2015) Khaled Radad et al.   Expert Review of Neurotherapeutics

Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke

(2015) Tudor G. Jovin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

(2015) Jeffrey L. Saver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

(2015) Bruce C.V. Campbell et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

(2015) Olvert A. Berkhemer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent advances in autophagy-based neuroprotection

(2015) Khaled Radad et al.   Expert Review of Neurotherapeutics

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

(2015) Joery Goossens et al.   Acta Neuropathologica Communications

The Potential Therapeutic Effect of Guanosine after Cortical Focal Ischemia in Rats

(2014) Gisele Hansel et al.   PLoS One

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

(2013) J. Janssens et al.   HUMAN MOLECULAR GENETICS

Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism

(2013) Ya Meng et al.   JOURNAL OF NEUROCHEMISTRY

Accelerated Disease Onset with Stabilized Familial Amyotrophic Lateral Sclerosis (ALS)-linked Mutant TDP-43 Proteins

(2012) Shoji Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice

(2012) Nobutoshi Morimoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal Rapamycin Rescues Mice from Staphylococcal Enterotoxin B-Induced Shock

(2012) Teresa Krakauer et al.   Toxins

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats

(2010) Masato Kanazawa et al.   JOURNAL OF NEUROCHEMISTRY

Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis

(2010) S. J. Barmada et al.   JOURNAL OF NEUROSCIENCE

Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

(2010) Chelsey Woodrum et al.   Journal of Translational Medicine

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

(2010) S.-C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed treatment with a p53 inhibitor enhances recovery in stroke brain

(2009) Yu Luo et al.   ANNALS OF NEUROLOGY

Rethinking ALS: The FUS about TDP-43

(2009) Clotilde Lagier-Tourenne et al.   CELL

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

(2009) G. S. Pesiridis et al.   HUMAN MOLECULAR GENETICS

Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability

(2009) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin: Discovery of Rapamycin Reveals a Signaling Pathway Important for Normal and Cancer Cell Growth

(2009) James J. Gibbons et al.   SEMINARS IN ONCOLOGY

Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator

(2009) Gregory J. del Zoppo et al.   STROKE

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2008) Masato Hasegawa et al.   ANNALS OF NEUROLOGY

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

(2008) Matthew J. Winton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY