Functional genomics in osteoarthritis: Past, present, and future

Systematic Identification, Characterization and Target Gene Analysis of microRNAs Involved in Osteoarthritis Subchondral Bone Pathogenesis

(2016) Indira Prasadam et al.   CALCIFIED TISSUE INTERNATIONAL

Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients

(2016) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk

(2015) Michael D. Rushton et al.   HUMAN MOLECULAR GENETICS

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments

(2015) C.-H. Chou et al.   OSTEOARTHRITIS AND CARTILAGE

Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients

(2015) M. Fu et al.   OSTEOARTHRITIS AND CARTILAGE

Transcriptional Associations of Osteoarthritis-Mediated Loss of Epigenetic Control in Articular Cartilage

(2015) Wouter den Hollander et al.   Arthritis & Rheumatology

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenetic differences in human cartilage between mild and severe OA

(2014) Florentine C. Moazedi-Fuerst et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31

(2014) Unnur Styrkarsdottir et al.   NATURE GENETICS

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

(2014) Hang Fang et al.   Nature Reviews Rheumatology

Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes

(2014) Simon R. Tew et al.   Arthritis & Rheumatology

Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Cartilage

(2014) Matlock A. Jeffries et al.   Arthritis & Rheumatology

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

(2014) Michael D. Rushton et al.   Arthritis & Rheumatology

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

Genes expressed in blood link osteoarthritis with apoptotic pathways

(2013) Yolande F M Ramos et al.   ANNALS OF THE RHEUMATIC DISEASES

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

(2013) Evangelos Evangelou et al.   ANNALS OF THE RHEUMATIC DISEASES

Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues

(2013) Susan Y. Ritter et al.   ARTHRITIS AND RHEUMATISM

Advances in osteoarthritis genetics: Table 1

(2013) Kalliope Panoutsopoulou et al.   JOURNAL OF MEDICAL GENETICS

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Relevance of zebrafish as an OA research model

(2013) P.M. van der Kraan   OSTEOARTHRITIS AND CARTILAGE

Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients

(2013) Johan Stenberg et al.   Proteome Science

Genome-wide expression profiles of subchondral bone in osteoarthritis

(2013) Ching-Heng Chou et al.   ARTHRITIS RESEARCH & THERAPY

A Global Increase in 5-Hydroxymethylcytosine Levels Marks Osteoarthritic Chondrocytes

(2013) Sarah E. B. Taylor et al.   Arthritis & Rheumatology

Gene Expression Pattern of Cells From Inflamed and Normal Areas of Osteoarthritis Synovial Membrane

(2013) Cécile Lambert et al.   Arthritis & Rheumatology

Long Noncoding RNA Related to Cartilage Injury Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis

(2013) Qiang Liu et al.   Arthritis & Rheumatology

Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis

(2012) Jesús Delgado-Calle et al.   ARTHRITIS AND RHEUMATISM

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

(2012) Y. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

(2012) M. Mahjoub et al.   OSTEOPOROSIS INTERNATIONAL

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

(2011) Mukundan Attur et al.   ARTHRITIS AND RHEUMATISM

Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis

(2010) J. R. Lamas et al.   ANNALS OF THE RHEUMATIC DISEASES

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis

(2010) C. Karlsson et al.   OSTEOARTHRITIS AND CARTILAGE

Differential proteome of bone marrow mesenchymal stem cells from osteoarthritis patients

(2008) R. Rollín et al.   OSTEOARTHRITIS AND CARTILAGE

Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology

(2008) M. Geyer et al.   OSTEOARTHRITIS AND CARTILAGE

Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis

(2008) Cristina Ruiz-Romero et al.   PROTEOMICS

Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis

(2007) S. Lambrecht et al.   OSTEOARTHRITIS AND CARTILAGE