Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

(2022) John T. Crowl et al.   NATURE IMMUNOLOGY

CD103 fate mapping reveals that intestinal CD103 − tissue-resident memory T cells are the primary responders to secondary infection

(2022) Helen Y. Fung et al.   Science Immunology

Secondary infections rejuvenate the intestinal CD103 + tissue-resident memory T cell pool

(2022) Madlaina von Hoesslin et al.   Science Immunology

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

(2021) Susan N. Christo et al.   NATURE IMMUNOLOGY

Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes

(2021) Loreto Parga-Vidal et al.   Science Immunology

A combined approach for single-cell mRNA and intracellular protein expression analysis

(2021) Johan Reimegård et al.   Communications Biology

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

(2021) Changwei Peng et al.   IMMUNITY

Single-cell chromatin state analysis with Signac

(2021) Tim Stuart et al.   NATURE METHODS

Developmental plasticity allows outside-in immune responses by resident memory T cells

(2020) Raissa Fonseca et al.   NATURE IMMUNOLOGY

Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

(2020) Inga Kavazović et al.   PLOS BIOLOGY

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

(2020) Nadia S. Kurd et al.   Science Immunology

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

(2020) Henrique Borges da Silva et al.   IMMUNITY

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection

(2020) J. Michael Stolley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

(2020) Felix M. Behr et al.   NATURE IMMUNOLOGY

Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection

(2020) Lara Labarta-Bajo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract

(2020) Bethany L. Macleod et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

(2020) J. Justin Milner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

(2020) Brigid S. Boland et al.   Science Immunology

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

(2020) Toshiro Hirai et al.   IMMUNITY

Pathophysiology of Inflammatory Bowel Diseases

(2020) John T. Chang   NEW ENGLAND JOURNAL OF MEDICINE

Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

(2019) Emily A. Thompson et al.   Cell Reports

Streamlined protocol for deep proteomic profiling of FAC-sorted cells and its application to freshly isolated murine immune cells

(2019) Samuel A Myers et al.   MOLECULAR & CELLULAR PROTEOMICS

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

(2019) Chaofan Li et al.   IMMUNITY

KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

(2018) Dietmar Herndler-Brandstetter et al.   IMMUNITY

Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

(2018) Lalit K. Beura et al.   NATURE IMMUNOLOGY

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

(2018) Simone L. Park et al.   NATURE IMMUNOLOGY

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

(2018) Henrique Borges da Silva et al.   NATURE

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

(2018) Lauren E. Holz et al.   Cell Reports

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

(2017) Stanley Cheuk et al.   IMMUNITY

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

(2016) Carmen Gerlach et al.   IMMUNITY

ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells

(2016) Chandra Sekhar Boddupalli et al.   JOURNAL OF CLINICAL INVESTIGATION

Local antigen in nonlymphoid tissue promotes resident memory CD8+T cell formation during viral infection

(2016) Tahsin N. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15–Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells

(2016) Jason M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

IL-7/Anti-IL-7 mAb Complexes Restore T Cell Development and Induce Homeostatic T Cell Expansion without Lymphopenia

(2014) O. Boyman et al.   JOURNAL OF IMMUNOLOGY

Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution

(2014) Lalit K. Beura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

Persistence of skin-resident memory T cells within an epidermal niche

(2014) A. Zaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

(2010) G. Jeannet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of mRNA and protein in complex biological samples

(2009) Tobias Maier et al.   FEBS LETTERS

Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells

(2009) D.-M. Zhao et al.   JOURNAL OF IMMUNOLOGY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY