Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Activating mTOR mutations are detrimental in nutrient-poor conditions.

(2022) Agata A. Bielska et al.   CANCER RESEARCH

Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit sensitivity to PI3Kα inhibitors

(2021) Yanyan Cai et al.   CANCER RESEARCH

Genetic and biological hallmarks of colorectal cancer

(2021) Jiexi Li et al.   GENES & DEVELOPMENT

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

(2021) Hannah N. Bell et al.   CANCER CELL

The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

(2020) Allison Ho Kowalsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dietary modifications for enhanced cancer therapy

(2020) Naama Kanarek et al.   NATURE

Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

(2020) Sung Rye Park et al.   Cell Reports

Role of mTORC1 in intestinal epithelial repair and tumorigenesis

(2019) Harleen Kaur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis

(2019) Sumeet Solanki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

(2019) Mytrang H. Do et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

(2018) Camila Rubio-Patiño et al.   Cell Metabolism

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

(2018) Kuang Shen et al.   NATURE

Nutrient and Metabolic Sensing in T Cell Responses

(2017) Jun Wei et al.   Frontiers in Immunology

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

(2016) Seung-Hyun Ro et al.   eLife

Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening

(2015) Joanna Trelinska et al.   ANTI-CANCER DRUGS

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

(2015) Dudley W. Lamming et al.   Oncotarget

Dietary protein restriction inhibits tumor growth in human xenograft models

(2015) Luigi Fontana et al.   Oncotarget

mTOR pathway in colorectal cancer: an update

(2015) Maria Giovanna Francipane et al.   Oncotarget

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

(2013) R. M. Young et al.   GENES & DEVELOPMENT

Tandutinib Inhibits the Akt/mTOR Signaling Pathway to Inhibit Colon Cancer Growth

(2013) S. Ponnurangam et al.   MOLECULAR CANCER THERAPEUTICS

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma

(2013) R. B. Corcoran et al.   Science Translational Medicine

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110  Inhibitors in PIK3CA-Mutant Breast Cancer

(2013) M. Elkabets et al.   Science Translational Medicine

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL