Administration of intramuscular AAV-BDNF and intranasal AAV-TrkB promotes neurological recovery via enhancing corticospinal synaptic connections in stroke rats

Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice

(2022) Kar Men Mah et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis

(2021) Hu Lv et al.   MOLECULAR NEUROBIOLOGY

A novel bone-thinning technique for transcranial stimulation motor-evoked potentials in rats

(2021) Yuyo Maeda et al.   Scientific Reports

Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders

(2021) Serena Camuso et al.   NEUROBIOLOGY OF DISEASE

Combined treatment with exercise and α5GABAAR inhibitor promotes motor function recovery after intracerebral hemorrhage

(2021) Takahiro Inoue et al.   NEUROSCIENCE LETTERS

Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

(2021) Gozal Bahlakeh et al.   Cell and Bioscience

Targeted tPA overexpression in denervated spinal motor neurons promotes stroke recovery in mice

(2020) Xinling Gan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-energy extracorporeal shock wave therapy promotes BDNF expression and improves functional recovery after spinal cord injury in rats

(2020) Michiharu Matsuda et al.   EXPERIMENTAL NEUROLOGY

GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases

(2020) Daayun Chung et al.   Frontiers in Cell and Developmental Biology

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

(2020) Surojit Paul et al.   EXPERIMENTAL NEUROLOGY

Neuronal activity and microglial activation support corticospinal tract and proprioceptive afferent sprouting in spinal circuits after a corticospinal system lesion

(2019) Yu-Qiu Jiang et al.   EXPERIMENTAL NEUROLOGY

Sensory deprivation after focal ischemia in mice accelerates brain remapping and improves functional recovery through Arc-dependent synaptic plasticity

(2018) Andrew W. Kraft et al.   Science Translational Medicine

Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice

(2018) Chaonan Lv et al.   Frontiers in Aging Neuroscience

Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses

(2018) Pei-Yi Lin et al.   Cell Reports

Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal

(2018) Naoyuki Murabe et al.   Scientific Reports

Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I

(2017) Lalitha R. Belur et al.   HUMAN GENE THERAPY

Effects of “nourishing liver and kidney” acupuncture therapy on expression of brain derived neurotrophic factor and synaptophysin after cerebral ischemia reperfusion in rats

(2017) Wen-guang Xia et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions

(2017) Yuanyuan Liu et al.   NEURON

Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion

(2017) Andrei A. Izmailov et al.   Frontiers in Pharmacology

The corticospinal tract: Evolution, development, and human disorders

(2016) Quentin Welniarz et al.   Developmental Neurobiology

D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability

(2016) Hong Lin et al.   Frontiers in Cellular Neuroscience

Brain-derived neurotrophic factor and its clinical implications

(2015) Siresha Bathina et al.   Archives of Medical Science

Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke

(2015) Denise A. Duricki et al.   BRAIN

Plasticity of subcortical pathways promote recovery of skilled hand function in rats after corticospinal and rubrospinal tract injuries

(2015) Guillermo García-Alías et al.   EXPERIMENTAL NEUROLOGY

Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

(2014) Jo Nijs et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments

(2014) Robert P Bonin et al.   Molecular Pain

Axonal Remodeling of the Corticospinal Tract in the Spinal Cord Contributes to Voluntary Motor Recovery After Stroke in Adult Mice

(2013) Zhongwu Liu et al.   STROKE

Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury

(2012) Masaki Ueno et al.   BRAIN

Lysosomal enzyme can bypass the blood–brain barrier and reach the CNS following intranasal administration

(2012) Daniel A. Wolf et al.   MOLECULAR GENETICS AND METABOLISM

Training-induced modifications of corticospinal reactivity in severely affected stroke survivors

(2012) Ruth N. Barker et al.   EXPERIMENTAL BRAIN RESEARCH

Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons

(2011) Sung E. Kwon et al.   NEURON

Ischemic Cerebral Damage

(2011) Jeannette Hofmeijer et al.   STROKE

Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats

(2010) Jeffrey C. Petruska et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Prediction of recovery of motor function after stroke

(2010) Cathy Stinear   LANCET NEUROLOGY

Environmental Enrichment Induces Synaptic Structural Modification After Transient Focal Cerebral Ischemia in Rats

(2009) Xiaohong Xu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

(2009) Sandra R. Alcalá-Barraza et al.   JOURNAL OF DRUG TARGETING

Muscle Injection of AAV-NT3 Promotes Anatomical Reorganization of CST Axons and Improves Behavioral Outcome following SCI

(2009) Jenny Fortun et al.   JOURNAL OF NEUROTRAUMA

Plasticity during stroke recovery: from synapse to behaviour

(2009) Timothy H. Murphy et al.   NATURE REVIEWS NEUROSCIENCE

Remodeling of the Corticospinal Innervation and Spontaneous Behavioral Recovery After Ischemic Stroke in Adult Mice

(2009) Zhongwu Liu et al.   STROKE

Descending Pathways in Motor Control

(2008) Roger N. Lemon   Annual Review of Neuroscience

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

(2008) M. Bergami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contralesional Axonal Remodeling of the Corticospinal System in Adult Rats After Stroke and Bone Marrow Stromal Cell Treatment

(2008) Zhongwu Liu et al.   STROKE